Water-Soluble Ruthenium (II) Complex Derived From Optically Pure Limonene and Its Microencapsulation Are Efficient Tools Against Bacterial Food Pathogen Biofilms: Escherichia coli, Staphylococcus aureus, Enteroccocus faecalis, and Listeria monocytogenes

Bioactive aminooxime ligands based on optically pure (R)-limonene have been synthesized in two steps. Their ruthenium (II) cationic water-soluble complex was prepared by a reaction between dichloro (para-cymene) ruthenium (II) dimers and aminooxime ligands in a 1:2 molar ratio. Antibacterial and ant...

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Autores principales:	Simon Khelissa, Yousra El Fannassi, Samah Mechmechani, Sakhr Alhuthali, Mohamed Amin El Amrani, Adem Gharsallaoui, Alexandre Barras, Nour-Eddine Chihib
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	ruthenium (II) limonene complexation microencapsulation biofilm antibacterial agent Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/018d20179f504e8c819d7dcdcc7e1aab
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spelling	oai:doaj.org-article:018d20179f504e8c819d7dcdcc7e1aab2021-11-19T08:57:01ZWater-Soluble Ruthenium (II) Complex Derived From Optically Pure Limonene and Its Microencapsulation Are Efficient Tools Against Bacterial Food Pathogen Biofilms: Escherichia coli, Staphylococcus aureus, Enteroccocus faecalis, and Listeria monocytogenes1664-302X10.3389/fmicb.2021.711326https://doaj.org/article/018d20179f504e8c819d7dcdcc7e1aab2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fmicb.2021.711326/fullhttps://doaj.org/toc/1664-302XBioactive aminooxime ligands based on optically pure (R)-limonene have been synthesized in two steps. Their ruthenium (II) cationic water-soluble complex was prepared by a reaction between dichloro (para-cymene) ruthenium (II) dimers and aminooxime ligands in a 1:2 molar ratio. Antibacterial and antibiofilm activities of the synthetized complex were assessed against Escherichia coli, Staphylococcus aureus, Listeria monocytogenes, and Enterococcus faecalis. The results revealed that the ruthenium (II) complex has higher antibacterial and antibiofilm activities in comparison with free ligands or the enantiopure (R)-limonene. Moreover, microencapsulation of this complex reduced its cytotoxicity and improved their minimum inhibitory concentration and antibiofilm activity toward the considered bacteria. The ruthenium (II) complex targets the bacterial cell membrane, which leads to rapid leakage of intracellular potassium. Our study suggests that the developed ruthenium (II) complexes could be useful as an alternative to conventional disinfectants.Simon KhelissaYousra El FannassiYousra El FannassiSamah MechmechaniSakhr AlhuthaliSakhr AlhuthaliMohamed Amin El AmraniAdem GharsallaouiAlexandre BarrasNour-Eddine ChihibFrontiers Media S.A.articleruthenium (II)limonenecomplexationmicroencapsulationbiofilmantibacterial agentMicrobiologyQR1-502ENFrontiers in Microbiology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	ruthenium (II) limonene complexation microencapsulation biofilm antibacterial agent Microbiology QR1-502
spellingShingle	ruthenium (II) limonene complexation microencapsulation biofilm antibacterial agent Microbiology QR1-502 Simon Khelissa Yousra El Fannassi Yousra El Fannassi Samah Mechmechani Sakhr Alhuthali Sakhr Alhuthali Mohamed Amin El Amrani Adem Gharsallaoui Alexandre Barras Nour-Eddine Chihib Water-Soluble Ruthenium (II) Complex Derived From Optically Pure Limonene and Its Microencapsulation Are Efficient Tools Against Bacterial Food Pathogen Biofilms: Escherichia coli, Staphylococcus aureus, Enteroccocus faecalis, and Listeria monocytogenes
description	Bioactive aminooxime ligands based on optically pure (R)-limonene have been synthesized in two steps. Their ruthenium (II) cationic water-soluble complex was prepared by a reaction between dichloro (para-cymene) ruthenium (II) dimers and aminooxime ligands in a 1:2 molar ratio. Antibacterial and antibiofilm activities of the synthetized complex were assessed against Escherichia coli, Staphylococcus aureus, Listeria monocytogenes, and Enterococcus faecalis. The results revealed that the ruthenium (II) complex has higher antibacterial and antibiofilm activities in comparison with free ligands or the enantiopure (R)-limonene. Moreover, microencapsulation of this complex reduced its cytotoxicity and improved their minimum inhibitory concentration and antibiofilm activity toward the considered bacteria. The ruthenium (II) complex targets the bacterial cell membrane, which leads to rapid leakage of intracellular potassium. Our study suggests that the developed ruthenium (II) complexes could be useful as an alternative to conventional disinfectants.
format	article
author	Simon Khelissa Yousra El Fannassi Yousra El Fannassi Samah Mechmechani Sakhr Alhuthali Sakhr Alhuthali Mohamed Amin El Amrani Adem Gharsallaoui Alexandre Barras Nour-Eddine Chihib
author_facet	Simon Khelissa Yousra El Fannassi Yousra El Fannassi Samah Mechmechani Sakhr Alhuthali Sakhr Alhuthali Mohamed Amin El Amrani Adem Gharsallaoui Alexandre Barras Nour-Eddine Chihib
author_sort	Simon Khelissa
title	Water-Soluble Ruthenium (II) Complex Derived From Optically Pure Limonene and Its Microencapsulation Are Efficient Tools Against Bacterial Food Pathogen Biofilms: Escherichia coli, Staphylococcus aureus, Enteroccocus faecalis, and Listeria monocytogenes
title_short	Water-Soluble Ruthenium (II) Complex Derived From Optically Pure Limonene and Its Microencapsulation Are Efficient Tools Against Bacterial Food Pathogen Biofilms: Escherichia coli, Staphylococcus aureus, Enteroccocus faecalis, and Listeria monocytogenes
title_full	Water-Soluble Ruthenium (II) Complex Derived From Optically Pure Limonene and Its Microencapsulation Are Efficient Tools Against Bacterial Food Pathogen Biofilms: Escherichia coli, Staphylococcus aureus, Enteroccocus faecalis, and Listeria monocytogenes
title_fullStr	Water-Soluble Ruthenium (II) Complex Derived From Optically Pure Limonene and Its Microencapsulation Are Efficient Tools Against Bacterial Food Pathogen Biofilms: Escherichia coli, Staphylococcus aureus, Enteroccocus faecalis, and Listeria monocytogenes
title_full_unstemmed	Water-Soluble Ruthenium (II) Complex Derived From Optically Pure Limonene and Its Microencapsulation Are Efficient Tools Against Bacterial Food Pathogen Biofilms: Escherichia coli, Staphylococcus aureus, Enteroccocus faecalis, and Listeria monocytogenes
title_sort	water-soluble ruthenium (ii) complex derived from optically pure limonene and its microencapsulation are efficient tools against bacterial food pathogen biofilms: escherichia coli, staphylococcus aureus, enteroccocus faecalis, and listeria monocytogenes
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/018d20179f504e8c819d7dcdcc7e1aab
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Water-Soluble Ruthenium (II) Complex Derived From Optically Pure Limonene and Its Microencapsulation Are Efficient Tools Against Bacterial Food Pathogen Biofilms: Escherichia coli, Staphylococcus aureus, Enteroccocus faecalis, and Listeria monocytogenes

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