Activation of NIX-mediated mitophagy by an interferon regulatory factor homologue of human herpesvirus

Impaired removal of damaged mitochondria by mitophagy can activate innate immune signaling, but impact on virus replication remains unclear. Here the authors show that viral IRF-1 of human herpesvirus 8 activates mitophagy via interaction with the mitophagy receptor NIX and that vIRF-1 induced mitop...

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Autores principales:	Mai Tram Vo, Barbara J. Smith, John Nicholas, Young Bong Choi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0190118766754883975cadf68938321e
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spelling	oai:doaj.org-article:0190118766754883975cadf68938321e2021-12-02T17:01:33ZActivation of NIX-mediated mitophagy by an interferon regulatory factor homologue of human herpesvirus10.1038/s41467-019-11164-22041-1723https://doaj.org/article/0190118766754883975cadf68938321e2019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11164-2https://doaj.org/toc/2041-1723Impaired removal of damaged mitochondria by mitophagy can activate innate immune signaling, but impact on virus replication remains unclear. Here the authors show that viral IRF-1 of human herpesvirus 8 activates mitophagy via interaction with the mitophagy receptor NIX and that vIRF-1 induced mitophagy supports productive infection.Mai Tram VoBarbara J. SmithJohn NicholasYoung Bong ChoiNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mai Tram Vo Barbara J. Smith John Nicholas Young Bong Choi Activation of NIX-mediated mitophagy by an interferon regulatory factor homologue of human herpesvirus
description	Impaired removal of damaged mitochondria by mitophagy can activate innate immune signaling, but impact on virus replication remains unclear. Here the authors show that viral IRF-1 of human herpesvirus 8 activates mitophagy via interaction with the mitophagy receptor NIX and that vIRF-1 induced mitophagy supports productive infection.
format	article
author	Mai Tram Vo Barbara J. Smith John Nicholas Young Bong Choi
author_facet	Mai Tram Vo Barbara J. Smith John Nicholas Young Bong Choi
author_sort	Mai Tram Vo
title	Activation of NIX-mediated mitophagy by an interferon regulatory factor homologue of human herpesvirus
title_short	Activation of NIX-mediated mitophagy by an interferon regulatory factor homologue of human herpesvirus
title_full	Activation of NIX-mediated mitophagy by an interferon regulatory factor homologue of human herpesvirus
title_fullStr	Activation of NIX-mediated mitophagy by an interferon regulatory factor homologue of human herpesvirus
title_full_unstemmed	Activation of NIX-mediated mitophagy by an interferon regulatory factor homologue of human herpesvirus
title_sort	activation of nix-mediated mitophagy by an interferon regulatory factor homologue of human herpesvirus
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/0190118766754883975cadf68938321e
work_keys_str_mv	AT maitramvo activationofnixmediatedmitophagybyaninterferonregulatoryfactorhomologueofhumanherpesvirus AT barbarajsmith activationofnixmediatedmitophagybyaninterferonregulatoryfactorhomologueofhumanherpesvirus AT johnnicholas activationofnixmediatedmitophagybyaninterferonregulatoryfactorhomologueofhumanherpesvirus AT youngbongchoi activationofnixmediatedmitophagybyaninterferonregulatoryfactorhomologueofhumanherpesvirus
_version_	1718382065234214912

Activation of NIX-mediated mitophagy by an interferon regulatory factor homologue of human herpesvirus

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