Activation of NIX-mediated mitophagy by an interferon regulatory factor homologue of human herpesvirus

Activation of NIX-mediated mitophagy by an interferon regulatory factor homologue of human herpesvirus

Impaired removal of damaged mitochondria by mitophagy can activate innate immune signaling, but impact on virus replication remains unclear. Here the authors show that viral IRF-1 of human herpesvirus 8 activates mitophagy via interaction with the mitophagy receptor NIX and that vIRF-1 induced mitop...

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Autores principales: Mai Tram Vo, Barbara J. Smith, John Nicholas, Young Bong Choi
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Science
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Acceso en línea:https://doaj.org/article/0190118766754883975cadf68938321e
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