In Silico Prediction of Steroids and Triterpenoids as Potential Regulators of Lipid Metabolism

This review focuses on a rare group of steroids and triterpenoids that share common properties as regulators of lipid metabolism. This group of compounds is divided by the type of chemical structure, and they represent: aromatic steroids, steroid phosphate esters, highly oxygenated steroids such as...

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Autor principal:	Valery M. Dembitsky
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	steroids triterpenoids hormones regulators lipid metabolism activity Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/0192bf3501d94ba6aa179106b998cbb5
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spelling	oai:doaj.org-article:0192bf3501d94ba6aa179106b998cbb52021-11-25T18:13:06ZIn Silico Prediction of Steroids and Triterpenoids as Potential Regulators of Lipid Metabolism10.3390/md191106501660-3397https://doaj.org/article/0192bf3501d94ba6aa179106b998cbb52021-11-01T00:00:00Zhttps://www.mdpi.com/1660-3397/19/11/650https://doaj.org/toc/1660-3397This review focuses on a rare group of steroids and triterpenoids that share common properties as regulators of lipid metabolism. This group of compounds is divided by the type of chemical structure, and they represent: aromatic steroids, steroid phosphate esters, highly oxygenated steroids such as steroid endoperoxides and hydroperoxides, α,β-epoxy steroids, and secosteroids. In addition, subgroups of carbon-bridged steroids, neo steroids, miscellaneous steroids, as well as synthetic steroids containing heteroatoms S (<i>epithio steroids</i>), Se (<i>selena steroids</i>), Te (<i>tellura steroids</i>), and At (<i>astatosteroids</i>) were presented. Natural steroids and triterpenoids have been found and identified from various sources such as marine sponges, soft corals, starfish, and other marine invertebrates. In addition, this group of rare lipids is found in fungi, fungal endophytes, and plants. The pharmacological profile of the presented steroids and triterpenoids was determined using the well-known computer program PASS, which is currently available online for all interested scientists and pharmacologists and is currently used by research teams from more than 130 countries of the world. Our attention has been focused on the biological activities of steroids and triterpenoids associated with the regulation of cholesterol metabolism and related processes such as anti-hyperlipoproteinemic activity, as well as the treatment of atherosclerosis, lipoprotein disorders, or inhibitors of cholesterol synthesis. In addition, individual steroids and triterpenoids were identified that demonstrated rare or unique biological activities such as treating neurodegenerative diseases, Alzheimer’s, and Parkinson’s diseases with a high degree of certainty over 95 percent. For individual steroids or triterpenoids or a group of compounds, 3D drawings of their predicted biological activities are presented.Valery M. DembitskyMDPI AGarticlesteroidstriterpenoidshormonesregulatorslipid metabolismactivityBiology (General)QH301-705.5ENMarine Drugs, Vol 19, Iss 650, p 650 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	steroids triterpenoids hormones regulators lipid metabolism activity Biology (General) QH301-705.5
spellingShingle	steroids triterpenoids hormones regulators lipid metabolism activity Biology (General) QH301-705.5 Valery M. Dembitsky In Silico Prediction of Steroids and Triterpenoids as Potential Regulators of Lipid Metabolism
description	This review focuses on a rare group of steroids and triterpenoids that share common properties as regulators of lipid metabolism. This group of compounds is divided by the type of chemical structure, and they represent: aromatic steroids, steroid phosphate esters, highly oxygenated steroids such as steroid endoperoxides and hydroperoxides, α,β-epoxy steroids, and secosteroids. In addition, subgroups of carbon-bridged steroids, neo steroids, miscellaneous steroids, as well as synthetic steroids containing heteroatoms S (<i>epithio steroids</i>), Se (<i>selena steroids</i>), Te (<i>tellura steroids</i>), and At (<i>astatosteroids</i>) were presented. Natural steroids and triterpenoids have been found and identified from various sources such as marine sponges, soft corals, starfish, and other marine invertebrates. In addition, this group of rare lipids is found in fungi, fungal endophytes, and plants. The pharmacological profile of the presented steroids and triterpenoids was determined using the well-known computer program PASS, which is currently available online for all interested scientists and pharmacologists and is currently used by research teams from more than 130 countries of the world. Our attention has been focused on the biological activities of steroids and triterpenoids associated with the regulation of cholesterol metabolism and related processes such as anti-hyperlipoproteinemic activity, as well as the treatment of atherosclerosis, lipoprotein disorders, or inhibitors of cholesterol synthesis. In addition, individual steroids and triterpenoids were identified that demonstrated rare or unique biological activities such as treating neurodegenerative diseases, Alzheimer’s, and Parkinson’s diseases with a high degree of certainty over 95 percent. For individual steroids or triterpenoids or a group of compounds, 3D drawings of their predicted biological activities are presented.
format	article
author	Valery M. Dembitsky
author_facet	Valery M. Dembitsky
author_sort	Valery M. Dembitsky
title	In Silico Prediction of Steroids and Triterpenoids as Potential Regulators of Lipid Metabolism
title_short	In Silico Prediction of Steroids and Triterpenoids as Potential Regulators of Lipid Metabolism
title_full	In Silico Prediction of Steroids and Triterpenoids as Potential Regulators of Lipid Metabolism
title_fullStr	In Silico Prediction of Steroids and Triterpenoids as Potential Regulators of Lipid Metabolism
title_full_unstemmed	In Silico Prediction of Steroids and Triterpenoids as Potential Regulators of Lipid Metabolism
title_sort	in silico prediction of steroids and triterpenoids as potential regulators of lipid metabolism
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/0192bf3501d94ba6aa179106b998cbb5
work_keys_str_mv	AT valerymdembitsky insilicopredictionofsteroidsandtriterpenoidsaspotentialregulatorsoflipidmetabolism
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In Silico Prediction of Steroids and Triterpenoids as Potential Regulators of Lipid Metabolism

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