Nuclear lamina integrity is required for proper spatial organization of chromatin in Drosophila

The role of the nuclear lamina (NL) in chromatin architecture is still poorly understood. Here, the authors provide evidence that disruption of the NL in Drosophila cells leads to overall chromatin compaction and repositioning from the nuclear envelope, whereas lamina-associated regions become less...

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Autores principales:	Sergey V. Ulianov, Semen A. Doronin, Ekaterina E. Khrameeva, Pavel I. Kos, Artem V. Luzhin, Sergei S. Starikov, Aleksandra A. Galitsyna, Valentina V. Nenasheva, Artem A. Ilyin, Ilya M. Flyamer, Elena A. Mikhaleva, Mariya D. Logacheva, Mikhail S. Gelfand, Alexander V. Chertovich, Alexey A. Gavrilov, Sergey V. Razin, Yuri Y. Shevelyov
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/019c5aaf61ed41efb63d52b8af38836b
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spelling	oai:doaj.org-article:019c5aaf61ed41efb63d52b8af38836b2021-12-02T16:58:28ZNuclear lamina integrity is required for proper spatial organization of chromatin in Drosophila10.1038/s41467-019-09185-y2041-1723https://doaj.org/article/019c5aaf61ed41efb63d52b8af38836b2019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09185-yhttps://doaj.org/toc/2041-1723The role of the nuclear lamina (NL) in chromatin architecture is still poorly understood. Here, the authors provide evidence that disruption of the NL in Drosophila cells leads to overall chromatin compaction and repositioning from the nuclear envelope, whereas lamina-associated regions become less compacted and transcription within them is increased.Sergey V. UlianovSemen A. DoroninEkaterina E. KhrameevaPavel I. KosArtem V. LuzhinSergei S. StarikovAleksandra A. GalitsynaValentina V. NenashevaArtem A. IlyinIlya M. FlyamerElena A. MikhalevaMariya D. LogachevaMikhail S. GelfandAlexander V. ChertovichAlexey A. GavrilovSergey V. RazinYuri Y. ShevelyovNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sergey V. Ulianov Semen A. Doronin Ekaterina E. Khrameeva Pavel I. Kos Artem V. Luzhin Sergei S. Starikov Aleksandra A. Galitsyna Valentina V. Nenasheva Artem A. Ilyin Ilya M. Flyamer Elena A. Mikhaleva Mariya D. Logacheva Mikhail S. Gelfand Alexander V. Chertovich Alexey A. Gavrilov Sergey V. Razin Yuri Y. Shevelyov Nuclear lamina integrity is required for proper spatial organization of chromatin in Drosophila
description	The role of the nuclear lamina (NL) in chromatin architecture is still poorly understood. Here, the authors provide evidence that disruption of the NL in Drosophila cells leads to overall chromatin compaction and repositioning from the nuclear envelope, whereas lamina-associated regions become less compacted and transcription within them is increased.
format	article
author	Sergey V. Ulianov Semen A. Doronin Ekaterina E. Khrameeva Pavel I. Kos Artem V. Luzhin Sergei S. Starikov Aleksandra A. Galitsyna Valentina V. Nenasheva Artem A. Ilyin Ilya M. Flyamer Elena A. Mikhaleva Mariya D. Logacheva Mikhail S. Gelfand Alexander V. Chertovich Alexey A. Gavrilov Sergey V. Razin Yuri Y. Shevelyov
author_facet	Sergey V. Ulianov Semen A. Doronin Ekaterina E. Khrameeva Pavel I. Kos Artem V. Luzhin Sergei S. Starikov Aleksandra A. Galitsyna Valentina V. Nenasheva Artem A. Ilyin Ilya M. Flyamer Elena A. Mikhaleva Mariya D. Logacheva Mikhail S. Gelfand Alexander V. Chertovich Alexey A. Gavrilov Sergey V. Razin Yuri Y. Shevelyov
author_sort	Sergey V. Ulianov
title	Nuclear lamina integrity is required for proper spatial organization of chromatin in Drosophila
title_short	Nuclear lamina integrity is required for proper spatial organization of chromatin in Drosophila
title_full	Nuclear lamina integrity is required for proper spatial organization of chromatin in Drosophila
title_fullStr	Nuclear lamina integrity is required for proper spatial organization of chromatin in Drosophila
title_full_unstemmed	Nuclear lamina integrity is required for proper spatial organization of chromatin in Drosophila
title_sort	nuclear lamina integrity is required for proper spatial organization of chromatin in drosophila
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/019c5aaf61ed41efb63d52b8af38836b
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Nuclear lamina integrity is required for proper spatial organization of chromatin in Drosophila

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