Visual acuity loss associated with excessive “dry macula” in exudative age-related macular degeneration
Hidenori Takahashi,1–3 Yuji Inoue,1,2 Xue Tan,2,3 Satoru Inoda,1 Shinichi Sakamoto,1 Yusuke Arai,1 Yasuo Yanagi,4–6 Yujiro Fujino,2,3 Hidetoshi Kawashima1 1Department of Ophthalmology, Jichi Medical University, Shimotsuke, 2Department of Ophthalmology, The University of Tokyo, B...
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Dove Medical Press
2018
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oai:doaj.org-article:019e22ec701143f9846df5543fc28e212021-12-02T00:06:42ZVisual acuity loss associated with excessive “dry macula” in exudative age-related macular degeneration1177-5483https://doaj.org/article/019e22ec701143f9846df5543fc28e212018-02-01T00:00:00Zhttps://www.dovepress.com/visual-acuity-loss-associated-with-excessive-dry-macula-in-exudative-a-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Hidenori Takahashi,1–3 Yuji Inoue,1,2 Xue Tan,2,3 Satoru Inoda,1 Shinichi Sakamoto,1 Yusuke Arai,1 Yasuo Yanagi,4–6 Yujiro Fujino,2,3 Hidetoshi Kawashima1 1Department of Ophthalmology, Jichi Medical University, Shimotsuke, 2Department of Ophthalmology, The University of Tokyo, Bunkyo, 3Department of Ophthalmology, Japan Community Health Care Organization Tokyo Shinjuku Medical Center, Shinjuku, Japan; 4Medical Retina, Singapore National Eye Centre, 5Medical Retina, Singapore Eye Research Institute, 6Eye-ACP, Duke NUS Medical School, National University of Singapore, Singapore Purpose: To investigate the correlation between visual acuity and central macular thickness (CMT) and choroidal thickness (CCT) in patients with wet age-related macular degeneration (AMD). Methods: In this retrospective analysis, 14 eyes that received >10 ranibizumab injections (based on pro re nata [PRN] regimen) and maintained initial visual acuity gain were analyzed. The following 5 parameters were measured at the foveal center: CMT (distance from the inner limiting membrane [ILM] to Bruch’s membrane); central retinal thickness (CRT; distance from the ILM to the inner limit of the retinal pigment epithelium or subretinal fluid [SRF]); SRF thickness (SRFT); pigment epithelium detachment thickness (PEDT); and CCT. The correlation between the logarithm of the minimum angle of resolution (logMAR) best-corrected visual acuity (BCVA) and the 5 parameters was examined with generalized estimating equations. Results: CMT, CRT, and CCT were negatively correlated with logMAR BCVA (P=0.031, 0.023, and 0.036, respectively) when only CMT values less than the thickness that maximized visual acuity for each eye were used for the analysis. Each 100-µm reduction in CMT, CRT, or CCT improved logMAR BCVA by -0.1, -0.08, or -0.07, respectively. SRFT and PEDT were not correlated with BCVA. The median CMT that maximized the visual acuity was 230 µm. Conclusion: Dry macula with CMT <230 µm was associated with temporary decrease in visual acuity in AMD patients whose visual acuity was maintained with PRN regimen. Keywords: age-related macular degeneration, intravitreal injections, ranibizumab, visual acuity, dry maculaTakahashi HInoue YTan XInoda SSakamoto SArai YYanagi YFujino YKawashima HDove Medical Pressarticleage-related macular degenerationintravitreal injectionsranibizumabvisual acuitydry maculaOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 12, Pp 369-375 (2018) |
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age-related macular degeneration intravitreal injections ranibizumab visual acuity dry macula Ophthalmology RE1-994 |
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age-related macular degeneration intravitreal injections ranibizumab visual acuity dry macula Ophthalmology RE1-994 Takahashi H Inoue Y Tan X Inoda S Sakamoto S Arai Y Yanagi Y Fujino Y Kawashima H Visual acuity loss associated with excessive “dry macula” in exudative age-related macular degeneration |
| description |
Hidenori Takahashi,1–3 Yuji Inoue,1,2 Xue Tan,2,3 Satoru Inoda,1 Shinichi Sakamoto,1 Yusuke Arai,1 Yasuo Yanagi,4–6 Yujiro Fujino,2,3 Hidetoshi Kawashima1 1Department of Ophthalmology, Jichi Medical University, Shimotsuke, 2Department of Ophthalmology, The University of Tokyo, Bunkyo, 3Department of Ophthalmology, Japan Community Health Care Organization Tokyo Shinjuku Medical Center, Shinjuku, Japan; 4Medical Retina, Singapore National Eye Centre, 5Medical Retina, Singapore Eye Research Institute, 6Eye-ACP, Duke NUS Medical School, National University of Singapore, Singapore Purpose: To investigate the correlation between visual acuity and central macular thickness (CMT) and choroidal thickness (CCT) in patients with wet age-related macular degeneration (AMD). Methods: In this retrospective analysis, 14 eyes that received >10 ranibizumab injections (based on pro re nata [PRN] regimen) and maintained initial visual acuity gain were analyzed. The following 5 parameters were measured at the foveal center: CMT (distance from the inner limiting membrane [ILM] to Bruch’s membrane); central retinal thickness (CRT; distance from the ILM to the inner limit of the retinal pigment epithelium or subretinal fluid [SRF]); SRF thickness (SRFT); pigment epithelium detachment thickness (PEDT); and CCT. The correlation between the logarithm of the minimum angle of resolution (logMAR) best-corrected visual acuity (BCVA) and the 5 parameters was examined with generalized estimating equations. Results: CMT, CRT, and CCT were negatively correlated with logMAR BCVA (P=0.031, 0.023, and 0.036, respectively) when only CMT values less than the thickness that maximized visual acuity for each eye were used for the analysis. Each 100-µm reduction in CMT, CRT, or CCT improved logMAR BCVA by -0.1, -0.08, or -0.07, respectively. SRFT and PEDT were not correlated with BCVA. The median CMT that maximized the visual acuity was 230 µm. Conclusion: Dry macula with CMT <230 µm was associated with temporary decrease in visual acuity in AMD patients whose visual acuity was maintained with PRN regimen. Keywords: age-related macular degeneration, intravitreal injections, ranibizumab, visual acuity, dry macula |
| format |
article |
| author |
Takahashi H Inoue Y Tan X Inoda S Sakamoto S Arai Y Yanagi Y Fujino Y Kawashima H |
| author_facet |
Takahashi H Inoue Y Tan X Inoda S Sakamoto S Arai Y Yanagi Y Fujino Y Kawashima H |
| author_sort |
Takahashi H |
| title |
Visual acuity loss associated with excessive “dry macula” in exudative age-related macular degeneration |
| title_short |
Visual acuity loss associated with excessive “dry macula” in exudative age-related macular degeneration |
| title_full |
Visual acuity loss associated with excessive “dry macula” in exudative age-related macular degeneration |
| title_fullStr |
Visual acuity loss associated with excessive “dry macula” in exudative age-related macular degeneration |
| title_full_unstemmed |
Visual acuity loss associated with excessive “dry macula” in exudative age-related macular degeneration |
| title_sort |
visual acuity loss associated with excessive “dry macula” in exudative age-related macular degeneration |
| publisher |
Dove Medical Press |
| publishDate |
2018 |
| url |
https://doaj.org/article/019e22ec701143f9846df5543fc28e21 |
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