Correlation Between Serum Uric Acid Level and Central Body Fat Distribution in Patients with Type 2 Diabetes

Jing Zong,1,2,* Yi Sun,1,* Yiqian Zhang,1,3 Jin Yuan,1 Xinlei Wang,1 Rongping Zhang,1 Xiaoqin Zhao,1 Xuying Zhao,1 Yunjuan Gu1 1Department of Endocrinology and Metabolism, The Affiliated Hospital of Nantong University, Nantong, Jiangsu Province, People’s Republic of China; 2Geriatric Depar...

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Autores principales:	Zong J, Sun Y, Zhang Y, Yuan J, Wang X, Zhang R, Zhao X, Gu Y
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	serum uric acid central obesity type 2 diabetes insulin resistance Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/019fe259bc4f44fab8bfbef020b1f837
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spelling	oai:doaj.org-article:019fe259bc4f44fab8bfbef020b1f8372021-12-02T10:33:52ZCorrelation Between Serum Uric Acid Level and Central Body Fat Distribution in Patients with Type 2 Diabetes1178-7007https://doaj.org/article/019fe259bc4f44fab8bfbef020b1f8372020-07-01T00:00:00Zhttps://www.dovepress.com/correlation-between-serum-uric-acid-level-and-central-body-fat-distrib-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Jing Zong,1,2,* Yi Sun,1,* Yiqian Zhang,1,3 Jin Yuan,1 Xinlei Wang,1 Rongping Zhang,1 Xiaoqin Zhao,1 Xuying Zhao,1 Yunjuan Gu1 1Department of Endocrinology and Metabolism, The Affiliated Hospital of Nantong University, Nantong, Jiangsu Province, People’s Republic of China; 2Geriatric Department, Nantong First Geriatric Hospital, Nantong, Jiangsu Province, People’s Republic of China; 3Department of Endocrinology and Metabolism, Changshu No.1 People’s Hospital, Nantong, Jiangsu Province, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yunjuan GuDepartment of Endocrinology and Metabolism, The Affiliated Hospital of Nantong University, 20 Xisi Road, Nantong, Jiangsu Province, People’s Republic of ChinaTel +86 15851207860Fax +86-513-8116-1906Email desette@ntu.edu.cnBackground: The aim of this study was to investigate the correlation between serum uric acid level and central body fat distribution in patients with type 2 diabetes (T2DM).Methods: A total of 867 patients with T2DM were enrolled. Measurements of central fat distribution were obtained by dual energy X-ray absorptiometry. Patients were stratified into three groups according to their levels of serum uric acid (SUA). Multiple linear regression analysis was used to determine the association between SUA and central body fat distribution. Logistic regression analysis was used to estimate the risk factors for hyperuricemia (HUA). Mediation analysis was applied to assess the overall, direct, and indirect mediators of SUA levels.Results: Multiple linear regression analysis showed that SUA levels were significantly positively correlated with waist circumference (WC), body mass index (BMI), visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), Android fat mass, Gynoid fat mass, fasting c-peptide (F-CP), and area under the curve of C-peptide (P < 0.05 for all). VAT [odds ratio (OR), 2.367; 95% confidence interval (CI), 1.078– 5.197; P < 0.001)], WC (OR, 1.041; 95% CI, 1.011– 1.072; P < 0.001), high-density lipoprotein (OR, 0.274; 95% CI, 0.104– 0.727; P < 0.001), and estimated glomerular filtration rate (OR, 0.966; 95% CI, 0.959– 0.973; P < 0.001) were found to be independent risk factors for T2DM patients with HUA. After mediation analysis, BMI and central obesity were found to have different partial effects on the association between SUA and F-CP (P < 0.001).Conclusion: In patients with T2DM, HUA was positively correlated with F-CP and central body fat distribution, especially VAT. These results suggest that central obesity may play a role in the positive correlation between HUA and insulin resistance (IR).Keywords: serum uric acid, central obesity, type 2 diabetes, insulin resistanceZong JSun YZhang YYuan JWang XZhang RZhao XZhao XGu YDove Medical Pressarticleserum uric acidcentral obesitytype 2 diabetesinsulin resistanceSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 13, Pp 2521-2531 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	serum uric acid central obesity type 2 diabetes insulin resistance Specialties of internal medicine RC581-951
spellingShingle	serum uric acid central obesity type 2 diabetes insulin resistance Specialties of internal medicine RC581-951 Zong J Sun Y Zhang Y Yuan J Wang X Zhang R Zhao X Zhao X Gu Y Correlation Between Serum Uric Acid Level and Central Body Fat Distribution in Patients with Type 2 Diabetes
description	Jing Zong,1,2,* Yi Sun,1,* Yiqian Zhang,1,3 Jin Yuan,1 Xinlei Wang,1 Rongping Zhang,1 Xiaoqin Zhao,1 Xuying Zhao,1 Yunjuan Gu1 1Department of Endocrinology and Metabolism, The Affiliated Hospital of Nantong University, Nantong, Jiangsu Province, People’s Republic of China; 2Geriatric Department, Nantong First Geriatric Hospital, Nantong, Jiangsu Province, People’s Republic of China; 3Department of Endocrinology and Metabolism, Changshu No.1 People’s Hospital, Nantong, Jiangsu Province, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yunjuan GuDepartment of Endocrinology and Metabolism, The Affiliated Hospital of Nantong University, 20 Xisi Road, Nantong, Jiangsu Province, People’s Republic of ChinaTel +86 15851207860Fax +86-513-8116-1906Email desette@ntu.edu.cnBackground: The aim of this study was to investigate the correlation between serum uric acid level and central body fat distribution in patients with type 2 diabetes (T2DM).Methods: A total of 867 patients with T2DM were enrolled. Measurements of central fat distribution were obtained by dual energy X-ray absorptiometry. Patients were stratified into three groups according to their levels of serum uric acid (SUA). Multiple linear regression analysis was used to determine the association between SUA and central body fat distribution. Logistic regression analysis was used to estimate the risk factors for hyperuricemia (HUA). Mediation analysis was applied to assess the overall, direct, and indirect mediators of SUA levels.Results: Multiple linear regression analysis showed that SUA levels were significantly positively correlated with waist circumference (WC), body mass index (BMI), visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), Android fat mass, Gynoid fat mass, fasting c-peptide (F-CP), and area under the curve of C-peptide (P < 0.05 for all). VAT [odds ratio (OR), 2.367; 95% confidence interval (CI), 1.078– 5.197; P < 0.001)], WC (OR, 1.041; 95% CI, 1.011– 1.072; P < 0.001), high-density lipoprotein (OR, 0.274; 95% CI, 0.104– 0.727; P < 0.001), and estimated glomerular filtration rate (OR, 0.966; 95% CI, 0.959– 0.973; P < 0.001) were found to be independent risk factors for T2DM patients with HUA. After mediation analysis, BMI and central obesity were found to have different partial effects on the association between SUA and F-CP (P < 0.001).Conclusion: In patients with T2DM, HUA was positively correlated with F-CP and central body fat distribution, especially VAT. These results suggest that central obesity may play a role in the positive correlation between HUA and insulin resistance (IR).Keywords: serum uric acid, central obesity, type 2 diabetes, insulin resistance
format	article
author	Zong J Sun Y Zhang Y Yuan J Wang X Zhang R Zhao X Zhao X Gu Y
author_facet	Zong J Sun Y Zhang Y Yuan J Wang X Zhang R Zhao X Zhao X Gu Y
author_sort	Zong J
title	Correlation Between Serum Uric Acid Level and Central Body Fat Distribution in Patients with Type 2 Diabetes
title_short	Correlation Between Serum Uric Acid Level and Central Body Fat Distribution in Patients with Type 2 Diabetes
title_full	Correlation Between Serum Uric Acid Level and Central Body Fat Distribution in Patients with Type 2 Diabetes
title_fullStr	Correlation Between Serum Uric Acid Level and Central Body Fat Distribution in Patients with Type 2 Diabetes
title_full_unstemmed	Correlation Between Serum Uric Acid Level and Central Body Fat Distribution in Patients with Type 2 Diabetes
title_sort	correlation between serum uric acid level and central body fat distribution in patients with type 2 diabetes
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/019fe259bc4f44fab8bfbef020b1f837
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Correlation Between Serum Uric Acid Level and Central Body Fat Distribution in Patients with Type 2 Diabetes

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