Structural dynamics of single SARS-CoV-2 pseudoknot molecules reveal topologically distinct conformers

The RNA pseudoknot of SARS-CoV-2 promotes -1 programmed ribosomal frameshifting. Here the authors use single molecule force spectroscopy to study the folding of this pseudoknot, showing that it forms at least two different pseudoknot conformers with distinct fold topologies.

Guardado en:

Detalles Bibliográficos
Autores principales:	Krishna Neupane, Meng Zhao, Aaron Lyons, Sneha Munshi, Sandaru M. Ileperuma, Dustin B. Ritchie, Noel Q. Hoffer, Abhishek Narayan, Michael T. Woodside
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/01a13bcf92534504aef2208c8b061c77
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:01a13bcf92534504aef2208c8b061c77
record_format	dspace
spelling	oai:doaj.org-article:01a13bcf92534504aef2208c8b061c772021-12-02T18:49:22ZStructural dynamics of single SARS-CoV-2 pseudoknot molecules reveal topologically distinct conformers10.1038/s41467-021-25085-62041-1723https://doaj.org/article/01a13bcf92534504aef2208c8b061c772021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25085-6https://doaj.org/toc/2041-1723The RNA pseudoknot of SARS-CoV-2 promotes -1 programmed ribosomal frameshifting. Here the authors use single molecule force spectroscopy to study the folding of this pseudoknot, showing that it forms at least two different pseudoknot conformers with distinct fold topologies.Krishna NeupaneMeng ZhaoAaron LyonsSneha MunshiSandaru M. IleperumaDustin B. RitchieNoel Q. HofferAbhishek NarayanMichael T. WoodsideNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Krishna Neupane Meng Zhao Aaron Lyons Sneha Munshi Sandaru M. Ileperuma Dustin B. Ritchie Noel Q. Hoffer Abhishek Narayan Michael T. Woodside Structural dynamics of single SARS-CoV-2 pseudoknot molecules reveal topologically distinct conformers
description	The RNA pseudoknot of SARS-CoV-2 promotes -1 programmed ribosomal frameshifting. Here the authors use single molecule force spectroscopy to study the folding of this pseudoknot, showing that it forms at least two different pseudoknot conformers with distinct fold topologies.
format	article
author	Krishna Neupane Meng Zhao Aaron Lyons Sneha Munshi Sandaru M. Ileperuma Dustin B. Ritchie Noel Q. Hoffer Abhishek Narayan Michael T. Woodside
author_facet	Krishna Neupane Meng Zhao Aaron Lyons Sneha Munshi Sandaru M. Ileperuma Dustin B. Ritchie Noel Q. Hoffer Abhishek Narayan Michael T. Woodside
author_sort	Krishna Neupane
title	Structural dynamics of single SARS-CoV-2 pseudoknot molecules reveal topologically distinct conformers
title_short	Structural dynamics of single SARS-CoV-2 pseudoknot molecules reveal topologically distinct conformers
title_full	Structural dynamics of single SARS-CoV-2 pseudoknot molecules reveal topologically distinct conformers
title_fullStr	Structural dynamics of single SARS-CoV-2 pseudoknot molecules reveal topologically distinct conformers
title_full_unstemmed	Structural dynamics of single SARS-CoV-2 pseudoknot molecules reveal topologically distinct conformers
title_sort	structural dynamics of single sars-cov-2 pseudoknot molecules reveal topologically distinct conformers
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/01a13bcf92534504aef2208c8b061c77
work_keys_str_mv	AT krishnaneupane structuraldynamicsofsinglesarscov2pseudoknotmoleculesrevealtopologicallydistinctconformers AT mengzhao structuraldynamicsofsinglesarscov2pseudoknotmoleculesrevealtopologicallydistinctconformers AT aaronlyons structuraldynamicsofsinglesarscov2pseudoknotmoleculesrevealtopologicallydistinctconformers AT snehamunshi structuraldynamicsofsinglesarscov2pseudoknotmoleculesrevealtopologicallydistinctconformers AT sandarumileperuma structuraldynamicsofsinglesarscov2pseudoknotmoleculesrevealtopologicallydistinctconformers AT dustinbritchie structuraldynamicsofsinglesarscov2pseudoknotmoleculesrevealtopologicallydistinctconformers AT noelqhoffer structuraldynamicsofsinglesarscov2pseudoknotmoleculesrevealtopologicallydistinctconformers AT abhisheknarayan structuraldynamicsofsinglesarscov2pseudoknotmoleculesrevealtopologicallydistinctconformers AT michaeltwoodside structuraldynamicsofsinglesarscov2pseudoknotmoleculesrevealtopologicallydistinctconformers
_version_	1718377543352975360

Structural dynamics of single SARS-CoV-2 pseudoknot molecules reveal topologically distinct conformers

Ejemplares similares