Quantitative comparison of corneal surface areas in keratoconus and normal eyes

Abstract Keratoconus is a highly prevalent corneal disorder characterized by progressive corneal thinning, steepening and irregular astigmatism. To date, pathophysiology of keratoconus development and progression remains debated. In this study, we retrospectively analysed topographic elevation maps...

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Autores principales:	François-Xavier Crahay, Guillaume Debellemanière, Stephan Tobalem, Wassim Ghazal, Sarah Moran, Damien Gatinel
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/01a151534228496e9a738c954869c8e2
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spelling	oai:doaj.org-article:01a151534228496e9a738c954869c8e22021-12-02T17:04:35ZQuantitative comparison of corneal surface areas in keratoconus and normal eyes10.1038/s41598-021-86185-32045-2322https://doaj.org/article/01a151534228496e9a738c954869c8e22021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-86185-3https://doaj.org/toc/2045-2322Abstract Keratoconus is a highly prevalent corneal disorder characterized by progressive corneal thinning, steepening and irregular astigmatism. To date, pathophysiology of keratoconus development and progression remains debated. In this study, we retrospectively analysed topographic elevation maps from 3227 eyes of 3227 patients (969 keratoconus and 2258 normal eyes) to calculate anterior and posterior corneal surface area. We compared results from normal eyes and keratoconus eyes using the Mann–Whitney U test. The Kruskal–Wallis test was used to compare keratoconus stages according to the Amsler–Krumeich classification. Keratoconus eyes were shown to have statistically significantly larger corneal surface areas, measured at the central 4.0 mm and 8.0 mm, and total corneal diameter. However, no significant increase in corneal surface area was seen with increasing severity of keratoconus. We suggest that these results indicate redistribution, rather than increase, of the corneal surface area with keratoconus severity.François-Xavier CrahayGuillaume DebellemanièreStephan TobalemWassim GhazalSarah MoranDamien GatinelNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q François-Xavier Crahay Guillaume Debellemanière Stephan Tobalem Wassim Ghazal Sarah Moran Damien Gatinel Quantitative comparison of corneal surface areas in keratoconus and normal eyes
description	Abstract Keratoconus is a highly prevalent corneal disorder characterized by progressive corneal thinning, steepening and irregular astigmatism. To date, pathophysiology of keratoconus development and progression remains debated. In this study, we retrospectively analysed topographic elevation maps from 3227 eyes of 3227 patients (969 keratoconus and 2258 normal eyes) to calculate anterior and posterior corneal surface area. We compared results from normal eyes and keratoconus eyes using the Mann–Whitney U test. The Kruskal–Wallis test was used to compare keratoconus stages according to the Amsler–Krumeich classification. Keratoconus eyes were shown to have statistically significantly larger corneal surface areas, measured at the central 4.0 mm and 8.0 mm, and total corneal diameter. However, no significant increase in corneal surface area was seen with increasing severity of keratoconus. We suggest that these results indicate redistribution, rather than increase, of the corneal surface area with keratoconus severity.
format	article
author	François-Xavier Crahay Guillaume Debellemanière Stephan Tobalem Wassim Ghazal Sarah Moran Damien Gatinel
author_facet	François-Xavier Crahay Guillaume Debellemanière Stephan Tobalem Wassim Ghazal Sarah Moran Damien Gatinel
author_sort	François-Xavier Crahay
title	Quantitative comparison of corneal surface areas in keratoconus and normal eyes
title_short	Quantitative comparison of corneal surface areas in keratoconus and normal eyes
title_full	Quantitative comparison of corneal surface areas in keratoconus and normal eyes
title_fullStr	Quantitative comparison of corneal surface areas in keratoconus and normal eyes
title_full_unstemmed	Quantitative comparison of corneal surface areas in keratoconus and normal eyes
title_sort	quantitative comparison of corneal surface areas in keratoconus and normal eyes
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/01a151534228496e9a738c954869c8e2
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Quantitative comparison of corneal surface areas in keratoconus and normal eyes

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