Function of selected natural antidiabetic compounds with potential against cancer via modulation of the PI3K/AKT/mTOR cascade

Diabetes mellitus (DM) is a metabolic disorder with growing global incidence, as 387 million people were diagnosed in 2014 with an expected projection of 642 million in 2040. Several complications are associated with DM including heart attack, stroke, kidney failure, blindness, and cancer. The latte...

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Autores principales:	Agustina Dwi Retno Nurcahyanti, Adeline Jap, Jullietta Lady, Deka Prismawan, Farukh Sharopov, Rachid Daoud, Michael Wink, Mansour Sobeh
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	PI3K/Akt/mTOR pathway Natural compound Antidiabetic Cancer Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/01a4058922c84b5292c822a3ee6938bd
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spelling	oai:doaj.org-article:01a4058922c84b5292c822a3ee6938bd2021-11-14T04:28:39ZFunction of selected natural antidiabetic compounds with potential against cancer via modulation of the PI3K/AKT/mTOR cascade0753-332210.1016/j.biopha.2021.112138https://doaj.org/article/01a4058922c84b5292c822a3ee6938bd2021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S0753332221009227https://doaj.org/toc/0753-3322Diabetes mellitus (DM) is a metabolic disorder with growing global incidence, as 387 million people were diagnosed in 2014 with an expected projection of 642 million in 2040. Several complications are associated with DM including heart attack, stroke, kidney failure, blindness, and cancer. The latter is the second leading cause of death worldwide accounting for one in every six deaths, with liver, pancreas, and endometrium cancers are the most abundant among patients with diabetes. Phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt)/mammalian target of rapamycin (mTOR) pathway plays a vital role in developing a wide array of pathological disorders, among them diabetes and cancer. Natural secondary metabolites that counteract the deleterious effects of reactive oxygen species (ROS) and modulate PI3K/Akt/mTOR pathway could be a promising approach in cancer therapy. Here, 717 medicinal plants with antidiabetic activities were highlighted along with 357 bioactive compounds responsible for the antidiabetic activity. Also, 43 individual plant compounds with potential antidiabetic activities against cancer via the modulation of PI3K/Akt/mTOR cascade were identified. Taken together, the available data give an insight of the potential of repurposing medicinal plants and/or the individual secondary metabolites with antidiabetic activities for cancer therapy.Agustina Dwi Retno NurcahyantiAdeline JapJullietta LadyDeka PrismawanFarukh SharopovRachid DaoudMichael WinkMansour SobehElsevierarticlePI3K/Akt/mTOR pathwayNatural compoundAntidiabeticCancerTherapeutics. PharmacologyRM1-950ENBiomedicine & Pharmacotherapy, Vol 144, Iss , Pp 112138- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	PI3K/Akt/mTOR pathway Natural compound Antidiabetic Cancer Therapeutics. Pharmacology RM1-950
spellingShingle	PI3K/Akt/mTOR pathway Natural compound Antidiabetic Cancer Therapeutics. Pharmacology RM1-950 Agustina Dwi Retno Nurcahyanti Adeline Jap Jullietta Lady Deka Prismawan Farukh Sharopov Rachid Daoud Michael Wink Mansour Sobeh Function of selected natural antidiabetic compounds with potential against cancer via modulation of the PI3K/AKT/mTOR cascade
description	Diabetes mellitus (DM) is a metabolic disorder with growing global incidence, as 387 million people were diagnosed in 2014 with an expected projection of 642 million in 2040. Several complications are associated with DM including heart attack, stroke, kidney failure, blindness, and cancer. The latter is the second leading cause of death worldwide accounting for one in every six deaths, with liver, pancreas, and endometrium cancers are the most abundant among patients with diabetes. Phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt)/mammalian target of rapamycin (mTOR) pathway plays a vital role in developing a wide array of pathological disorders, among them diabetes and cancer. Natural secondary metabolites that counteract the deleterious effects of reactive oxygen species (ROS) and modulate PI3K/Akt/mTOR pathway could be a promising approach in cancer therapy. Here, 717 medicinal plants with antidiabetic activities were highlighted along with 357 bioactive compounds responsible for the antidiabetic activity. Also, 43 individual plant compounds with potential antidiabetic activities against cancer via the modulation of PI3K/Akt/mTOR cascade were identified. Taken together, the available data give an insight of the potential of repurposing medicinal plants and/or the individual secondary metabolites with antidiabetic activities for cancer therapy.
format	article
author	Agustina Dwi Retno Nurcahyanti Adeline Jap Jullietta Lady Deka Prismawan Farukh Sharopov Rachid Daoud Michael Wink Mansour Sobeh
author_facet	Agustina Dwi Retno Nurcahyanti Adeline Jap Jullietta Lady Deka Prismawan Farukh Sharopov Rachid Daoud Michael Wink Mansour Sobeh
author_sort	Agustina Dwi Retno Nurcahyanti
title	Function of selected natural antidiabetic compounds with potential against cancer via modulation of the PI3K/AKT/mTOR cascade
title_short	Function of selected natural antidiabetic compounds with potential against cancer via modulation of the PI3K/AKT/mTOR cascade
title_full	Function of selected natural antidiabetic compounds with potential against cancer via modulation of the PI3K/AKT/mTOR cascade
title_fullStr	Function of selected natural antidiabetic compounds with potential against cancer via modulation of the PI3K/AKT/mTOR cascade
title_full_unstemmed	Function of selected natural antidiabetic compounds with potential against cancer via modulation of the PI3K/AKT/mTOR cascade
title_sort	function of selected natural antidiabetic compounds with potential against cancer via modulation of the pi3k/akt/mtor cascade
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/01a4058922c84b5292c822a3ee6938bd
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Function of selected natural antidiabetic compounds with potential against cancer via modulation of the PI3K/AKT/mTOR cascade

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