Long-term autophagy is sustained by activation of CCTβ3 on lipid droplets

The source of phospholipids to generate autophagosomal membranes, particularly after prolonged starvation, is not well characterized. Here, the authors show that CCTβ3, the rate limiting enzyme in phosphatidylcholine synthesis, is activated on lipid droplets and sustains long-term autophagy.

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Autores principales:	Yuta Ogasawara, Jinglei Cheng, Tsuyako Tatematsu, Misaki Uchida, Omi Murase, Shogo Yoshikawa, Yuki Ohsaki, Toyoshi Fujimoto
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/01aa050b4596409a8597336a1d223531
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id	oai:doaj.org-article:01aa050b4596409a8597336a1d223531
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spelling	oai:doaj.org-article:01aa050b4596409a8597336a1d2235312021-12-02T19:12:28ZLong-term autophagy is sustained by activation of CCTβ3 on lipid droplets10.1038/s41467-020-18153-w2041-1723https://doaj.org/article/01aa050b4596409a8597336a1d2235312020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18153-whttps://doaj.org/toc/2041-1723The source of phospholipids to generate autophagosomal membranes, particularly after prolonged starvation, is not well characterized. Here, the authors show that CCTβ3, the rate limiting enzyme in phosphatidylcholine synthesis, is activated on lipid droplets and sustains long-term autophagy.Yuta OgasawaraJinglei ChengTsuyako TatematsuMisaki UchidaOmi MuraseShogo YoshikawaYuki OhsakiToyoshi FujimotoNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yuta Ogasawara Jinglei Cheng Tsuyako Tatematsu Misaki Uchida Omi Murase Shogo Yoshikawa Yuki Ohsaki Toyoshi Fujimoto Long-term autophagy is sustained by activation of CCTβ3 on lipid droplets
description	The source of phospholipids to generate autophagosomal membranes, particularly after prolonged starvation, is not well characterized. Here, the authors show that CCTβ3, the rate limiting enzyme in phosphatidylcholine synthesis, is activated on lipid droplets and sustains long-term autophagy.
format	article
author	Yuta Ogasawara Jinglei Cheng Tsuyako Tatematsu Misaki Uchida Omi Murase Shogo Yoshikawa Yuki Ohsaki Toyoshi Fujimoto
author_facet	Yuta Ogasawara Jinglei Cheng Tsuyako Tatematsu Misaki Uchida Omi Murase Shogo Yoshikawa Yuki Ohsaki Toyoshi Fujimoto
author_sort	Yuta Ogasawara
title	Long-term autophagy is sustained by activation of CCTβ3 on lipid droplets
title_short	Long-term autophagy is sustained by activation of CCTβ3 on lipid droplets
title_full	Long-term autophagy is sustained by activation of CCTβ3 on lipid droplets
title_fullStr	Long-term autophagy is sustained by activation of CCTβ3 on lipid droplets
title_full_unstemmed	Long-term autophagy is sustained by activation of CCTβ3 on lipid droplets
title_sort	long-term autophagy is sustained by activation of cctβ3 on lipid droplets
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/01aa050b4596409a8597336a1d223531
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Long-term autophagy is sustained by activation of CCTβ3 on lipid droplets

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