Meta-analysis identifies five novel loci associated with endometriosis highlighting key genes involved in hormone metabolism
Endometriosis is a major cause of infertility. Molecular mechanisms underlying the disease involve genetic and environmental risk factors. In a meta-analysis of eleven GWA studies, Sapkota and colleagues identify five novel risk loci, implicating steroid sex hormone pathways in the pathogenesis.
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Nature Portfolio
2017
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oai:doaj.org-article:01ad40bb5e464263812572052ae10cf62021-12-02T14:42:02ZMeta-analysis identifies five novel loci associated with endometriosis highlighting key genes involved in hormone metabolism10.1038/ncomms155392041-1723https://doaj.org/article/01ad40bb5e464263812572052ae10cf62017-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms15539https://doaj.org/toc/2041-1723Endometriosis is a major cause of infertility. Molecular mechanisms underlying the disease involve genetic and environmental risk factors. In a meta-analysis of eleven GWA studies, Sapkota and colleagues identify five novel risk loci, implicating steroid sex hormone pathways in the pathogenesis.Yadav SapkotaValgerdur SteinthorsdottirAndrew P. MorrisAmelie FassbenderNilufer RahmiogluImmaculata De VivoJulie E. BuringFutao ZhangTodd L. EdwardsSarah JonesDorien ODaniëlle PeterseKathryn M. RexrodePaul M. RidkerAndrew J. SchorkStuart MacGregorNicholas G. MartinChristian M. BeckerSosuke AdachiKosuke YoshiharaTakayuki EnomotoAtsushi TakahashiYoichiro KamataniKoichi MatsudaMichiaki KuboGudmar ThorleifssonReynir T. GeirssonUnnur ThorsteinsdottirLeanne M. WallaceiPSYCH-SSI-Broad GroupJian YangDigna R. Velez EdwardsMette NyegaardSiew-Kee LowKrina T. ZondervanStacey A. MissmerThomas D'HoogheGrant W. MontgomeryDaniel I. ChasmanKari StefanssonJoyce Y. TungDale R. NyholtNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017) |
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DOAJ |
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EN |
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Science Q |
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Science Q Yadav Sapkota Valgerdur Steinthorsdottir Andrew P. Morris Amelie Fassbender Nilufer Rahmioglu Immaculata De Vivo Julie E. Buring Futao Zhang Todd L. Edwards Sarah Jones Dorien O Daniëlle Peterse Kathryn M. Rexrode Paul M. Ridker Andrew J. Schork Stuart MacGregor Nicholas G. Martin Christian M. Becker Sosuke Adachi Kosuke Yoshihara Takayuki Enomoto Atsushi Takahashi Yoichiro Kamatani Koichi Matsuda Michiaki Kubo Gudmar Thorleifsson Reynir T. Geirsson Unnur Thorsteinsdottir Leanne M. Wallace iPSYCH-SSI-Broad Group Jian Yang Digna R. Velez Edwards Mette Nyegaard Siew-Kee Low Krina T. Zondervan Stacey A. Missmer Thomas D'Hooghe Grant W. Montgomery Daniel I. Chasman Kari Stefansson Joyce Y. Tung Dale R. Nyholt Meta-analysis identifies five novel loci associated with endometriosis highlighting key genes involved in hormone metabolism |
| description |
Endometriosis is a major cause of infertility. Molecular mechanisms underlying the disease involve genetic and environmental risk factors. In a meta-analysis of eleven GWA studies, Sapkota and colleagues identify five novel risk loci, implicating steroid sex hormone pathways in the pathogenesis. |
| format |
article |
| author |
Yadav Sapkota Valgerdur Steinthorsdottir Andrew P. Morris Amelie Fassbender Nilufer Rahmioglu Immaculata De Vivo Julie E. Buring Futao Zhang Todd L. Edwards Sarah Jones Dorien O Daniëlle Peterse Kathryn M. Rexrode Paul M. Ridker Andrew J. Schork Stuart MacGregor Nicholas G. Martin Christian M. Becker Sosuke Adachi Kosuke Yoshihara Takayuki Enomoto Atsushi Takahashi Yoichiro Kamatani Koichi Matsuda Michiaki Kubo Gudmar Thorleifsson Reynir T. Geirsson Unnur Thorsteinsdottir Leanne M. Wallace iPSYCH-SSI-Broad Group Jian Yang Digna R. Velez Edwards Mette Nyegaard Siew-Kee Low Krina T. Zondervan Stacey A. Missmer Thomas D'Hooghe Grant W. Montgomery Daniel I. Chasman Kari Stefansson Joyce Y. Tung Dale R. Nyholt |
| author_facet |
Yadav Sapkota Valgerdur Steinthorsdottir Andrew P. Morris Amelie Fassbender Nilufer Rahmioglu Immaculata De Vivo Julie E. Buring Futao Zhang Todd L. Edwards Sarah Jones Dorien O Daniëlle Peterse Kathryn M. Rexrode Paul M. Ridker Andrew J. Schork Stuart MacGregor Nicholas G. Martin Christian M. Becker Sosuke Adachi Kosuke Yoshihara Takayuki Enomoto Atsushi Takahashi Yoichiro Kamatani Koichi Matsuda Michiaki Kubo Gudmar Thorleifsson Reynir T. Geirsson Unnur Thorsteinsdottir Leanne M. Wallace iPSYCH-SSI-Broad Group Jian Yang Digna R. Velez Edwards Mette Nyegaard Siew-Kee Low Krina T. Zondervan Stacey A. Missmer Thomas D'Hooghe Grant W. Montgomery Daniel I. Chasman Kari Stefansson Joyce Y. Tung Dale R. Nyholt |
| author_sort |
Yadav Sapkota |
| title |
Meta-analysis identifies five novel loci associated with endometriosis highlighting key genes involved in hormone metabolism |
| title_short |
Meta-analysis identifies five novel loci associated with endometriosis highlighting key genes involved in hormone metabolism |
| title_full |
Meta-analysis identifies five novel loci associated with endometriosis highlighting key genes involved in hormone metabolism |
| title_fullStr |
Meta-analysis identifies five novel loci associated with endometriosis highlighting key genes involved in hormone metabolism |
| title_full_unstemmed |
Meta-analysis identifies five novel loci associated with endometriosis highlighting key genes involved in hormone metabolism |
| title_sort |
meta-analysis identifies five novel loci associated with endometriosis highlighting key genes involved in hormone metabolism |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/01ad40bb5e464263812572052ae10cf6 |
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