Identification of the PTEN-ARID4B-PI3K pathway reveals the dependency on ARID4B by PTEN-deficient prostate cancer

Identification of the PTEN-ARID4B-PI3K pathway reveals the dependency on ARID4B by PTEN-deficient prostate cancer

The identification of synthetic essential genes of PTEN is of therapeutic potential for PTEN-deficient prostate cancers. Here, the authors show that ARID4B is a synthetic essential gene in these cancers in which deficiency of PTEN prompts the AKT-ARID4B feedback loop required for activation of the P...

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Autores principales: Ray-Chang Wu, In-Chi Young, Yu-Fang Chen, Sung-Ting Chuang, Antoun Toubaji, Mei-Yi Wu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/01af43eeb4fd48ae85a727b83845cf1a
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spelling oai:doaj.org-article:01af43eeb4fd48ae85a727b83845cf1a2021-12-02T15:35:51ZIdentification of the PTEN-ARID4B-PI3K pathway reveals the dependency on ARID4B by PTEN-deficient prostate cancer10.1038/s41467-019-12184-82041-1723https://doaj.org/article/01af43eeb4fd48ae85a727b83845cf1a2019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12184-8https://doaj.org/toc/2041-1723The identification of synthetic essential genes of PTEN is of therapeutic potential for PTEN-deficient prostate cancers. Here, the authors show that ARID4B is a synthetic essential gene in these cancers in which deficiency of PTEN prompts the AKT-ARID4B feedback loop required for activation of the PI3K-AKT signaling pathway.Ray-Chang WuIn-Chi YoungYu-Fang ChenSung-Ting ChuangAntoun ToubajiMei-Yi WuNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Ray-Chang Wu
In-Chi Young
Yu-Fang Chen
Sung-Ting Chuang
Antoun Toubaji
Mei-Yi Wu
Identification of the PTEN-ARID4B-PI3K pathway reveals the dependency on ARID4B by PTEN-deficient prostate cancer
description The identification of synthetic essential genes of PTEN is of therapeutic potential for PTEN-deficient prostate cancers. Here, the authors show that ARID4B is a synthetic essential gene in these cancers in which deficiency of PTEN prompts the AKT-ARID4B feedback loop required for activation of the PI3K-AKT signaling pathway.
format article
author Ray-Chang Wu
In-Chi Young
Yu-Fang Chen
Sung-Ting Chuang
Antoun Toubaji
Mei-Yi Wu
author_facet Ray-Chang Wu
In-Chi Young
Yu-Fang Chen
Sung-Ting Chuang
Antoun Toubaji
Mei-Yi Wu
author_sort Ray-Chang Wu
title Identification of the PTEN-ARID4B-PI3K pathway reveals the dependency on ARID4B by PTEN-deficient prostate cancer
title_short Identification of the PTEN-ARID4B-PI3K pathway reveals the dependency on ARID4B by PTEN-deficient prostate cancer
title_full Identification of the PTEN-ARID4B-PI3K pathway reveals the dependency on ARID4B by PTEN-deficient prostate cancer
title_fullStr Identification of the PTEN-ARID4B-PI3K pathway reveals the dependency on ARID4B by PTEN-deficient prostate cancer
title_full_unstemmed Identification of the PTEN-ARID4B-PI3K pathway reveals the dependency on ARID4B by PTEN-deficient prostate cancer
title_sort identification of the pten-arid4b-pi3k pathway reveals the dependency on arid4b by pten-deficient prostate cancer
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/01af43eeb4fd48ae85a727b83845cf1a
work_keys_str_mv AT raychangwu identificationoftheptenarid4bpi3kpathwayrevealsthedependencyonarid4bbyptendeficientprostatecancer
AT inchiyoung identificationoftheptenarid4bpi3kpathwayrevealsthedependencyonarid4bbyptendeficientprostatecancer
AT yufangchen identificationoftheptenarid4bpi3kpathwayrevealsthedependencyonarid4bbyptendeficientprostatecancer
AT sungtingchuang identificationoftheptenarid4bpi3kpathwayrevealsthedependencyonarid4bbyptendeficientprostatecancer
AT antountoubaji identificationoftheptenarid4bpi3kpathwayrevealsthedependencyonarid4bbyptendeficientprostatecancer
AT meiyiwu identificationoftheptenarid4bpi3kpathwayrevealsthedependencyonarid4bbyptendeficientprostatecancer
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