Unravelling the Anticancer Mechanisms of Traditional Herbal Medicines with Metabolomics

Metabolite profiling of cancer cells presents many opportunities for anticancer drug discovery. The Chinese, Indian, and African flora, in particular, offers a diverse source of anticancer therapeutics as documented in traditional folklores. In-depth scientific information relating to mechanisms of...

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Autores principales:	Omolola R. Oyenihi, Ayodeji B. Oyenihi, Joseph O. Erhabor, Motlalepula G. Matsabisa, Oluwafemi O. Oguntibeju
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	cancer herb metabolic reprogramming metabolomics phytomedicine Organic chemistry QD241-441
Acceso en línea:	https://doaj.org/article/01b12944cb5a473fbfa054bdb1723926
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spelling	oai:doaj.org-article:01b12944cb5a473fbfa054bdb17239262021-11-11T18:31:39ZUnravelling the Anticancer Mechanisms of Traditional Herbal Medicines with Metabolomics10.3390/molecules262165411420-3049https://doaj.org/article/01b12944cb5a473fbfa054bdb17239262021-10-01T00:00:00Zhttps://www.mdpi.com/1420-3049/26/21/6541https://doaj.org/toc/1420-3049Metabolite profiling of cancer cells presents many opportunities for anticancer drug discovery. The Chinese, Indian, and African flora, in particular, offers a diverse source of anticancer therapeutics as documented in traditional folklores. In-depth scientific information relating to mechanisms of action, quality control, and safety profile will promote their extensive usage in cancer therapy. Metabolomics may be a more holistic strategy to gain valuable insights into the anticancer mechanisms of action of plants but this has remained largely unexplored. This review, therefore, presents the available metabolomics studies on the anticancer effects of herbal medicines commonly used in Africa and Asia. In addition, we present some scientifically understudied ‘candidate plants’ for cancer metabolomics studies and highlight the relevance of metabolomics in addressing other challenges facing the drug development of anticancer herbs. Finally, we discussed the challenges of using metabolomics to uncover the underlying mechanisms of potential anticancer herbs and the progress made in this regard.Omolola R. OyenihiAyodeji B. OyenihiJoseph O. ErhaborMotlalepula G. MatsabisaOluwafemi O. OguntibejuMDPI AGarticlecancerherbmetabolic reprogrammingmetabolomicsphytomedicineOrganic chemistryQD241-441ENMolecules, Vol 26, Iss 6541, p 6541 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cancer herb metabolic reprogramming metabolomics phytomedicine Organic chemistry QD241-441
spellingShingle	cancer herb metabolic reprogramming metabolomics phytomedicine Organic chemistry QD241-441 Omolola R. Oyenihi Ayodeji B. Oyenihi Joseph O. Erhabor Motlalepula G. Matsabisa Oluwafemi O. Oguntibeju Unravelling the Anticancer Mechanisms of Traditional Herbal Medicines with Metabolomics
description	Metabolite profiling of cancer cells presents many opportunities for anticancer drug discovery. The Chinese, Indian, and African flora, in particular, offers a diverse source of anticancer therapeutics as documented in traditional folklores. In-depth scientific information relating to mechanisms of action, quality control, and safety profile will promote their extensive usage in cancer therapy. Metabolomics may be a more holistic strategy to gain valuable insights into the anticancer mechanisms of action of plants but this has remained largely unexplored. This review, therefore, presents the available metabolomics studies on the anticancer effects of herbal medicines commonly used in Africa and Asia. In addition, we present some scientifically understudied ‘candidate plants’ for cancer metabolomics studies and highlight the relevance of metabolomics in addressing other challenges facing the drug development of anticancer herbs. Finally, we discussed the challenges of using metabolomics to uncover the underlying mechanisms of potential anticancer herbs and the progress made in this regard.
format	article
author	Omolola R. Oyenihi Ayodeji B. Oyenihi Joseph O. Erhabor Motlalepula G. Matsabisa Oluwafemi O. Oguntibeju
author_facet	Omolola R. Oyenihi Ayodeji B. Oyenihi Joseph O. Erhabor Motlalepula G. Matsabisa Oluwafemi O. Oguntibeju
author_sort	Omolola R. Oyenihi
title	Unravelling the Anticancer Mechanisms of Traditional Herbal Medicines with Metabolomics
title_short	Unravelling the Anticancer Mechanisms of Traditional Herbal Medicines with Metabolomics
title_full	Unravelling the Anticancer Mechanisms of Traditional Herbal Medicines with Metabolomics
title_fullStr	Unravelling the Anticancer Mechanisms of Traditional Herbal Medicines with Metabolomics
title_full_unstemmed	Unravelling the Anticancer Mechanisms of Traditional Herbal Medicines with Metabolomics
title_sort	unravelling the anticancer mechanisms of traditional herbal medicines with metabolomics
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/01b12944cb5a473fbfa054bdb1723926
work_keys_str_mv	AT omololaroyenihi unravellingtheanticancermechanismsoftraditionalherbalmedicineswithmetabolomics AT ayodejiboyenihi unravellingtheanticancermechanismsoftraditionalherbalmedicineswithmetabolomics AT josephoerhabor unravellingtheanticancermechanismsoftraditionalherbalmedicineswithmetabolomics AT motlalepulagmatsabisa unravellingtheanticancermechanismsoftraditionalherbalmedicineswithmetabolomics AT oluwafemiooguntibeju unravellingtheanticancermechanismsoftraditionalherbalmedicineswithmetabolomics
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Unravelling the Anticancer Mechanisms of Traditional Herbal Medicines with Metabolomics

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