Urinary NGAL is a Potential Biomarker for Early Renal Injury in Insulin Resistant Obese Non-diabetic Children

Objective:Neutrophil gelatinase-associated lipocalin (NGAL) is one of the new biomarkers for detecting acute renal injury. There are studies showing the relationship between NGAL and renal injury in obese children. The aim of this study was to investigate whether urinary levels of NGAL, kidney injur...

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Autores principales:	Semra Şen, Deniz Özalp Kızılay, Fatma Taneli, Çınar Özen, Pelin Ertan, İpek Özunan, Raziye Yıldız, Betül Ersoy
Formato:	article
Lenguaje:	EN
Publicado:	Galenos Yayincilik 2021
Materias:	ngal renal injury child kim-1 insulin resistance Pediatrics RJ1-570 Diseases of the endocrine glands. Clinical endocrinology RC648-665
Acceso en línea:	https://doaj.org/article/01b24f4a1e7145d1b71c6be0c7d873bb
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spelling	oai:doaj.org-article:01b24f4a1e7145d1b71c6be0c7d873bb2021-11-26T06:10:16ZUrinary NGAL is a Potential Biomarker for Early Renal Injury in Insulin Resistant Obese Non-diabetic Children1308-57271308-573510.4274/jcrpe.galenos.2021.2021.0020https://doaj.org/article/01b24f4a1e7145d1b71c6be0c7d873bb2021-12-01T00:00:00Z http://www.jcrpe.org/archives/archive-detail/article-preview/urinary-ngal-is-a-potential-biomarker-for-early-re/47427 https://doaj.org/toc/1308-5727https://doaj.org/toc/1308-5735Objective:Neutrophil gelatinase-associated lipocalin (NGAL) is one of the new biomarkers for detecting acute renal injury. There are studies showing the relationship between NGAL and renal injury in obese children. The aim of this study was to investigate whether urinary levels of NGAL, kidney injury molecule-1, and serum cystatin C are increased in insulin resistance (IR) patients before the development of diabetes.Methods:Cross-sectional, case-controlled study that included non-diabetic obese children and adolescent patients with IR and a nondiabetic obese control group with no IR, who attended a tertiary center pediatric endocrinology outpatient clinic between 2016-2018. Those with diabetes mellitus and/or known renal disease were excluded. NGAL and creatinine (Cr) levels were evaluated in the morning spot urine from all participants. Serum renal function was evaluated.Results:Thirty-six control and 63 IR patients were included in the study, of whom 68 (68.7%) were girls. The mean age of all participants was 13.12±2.64 years and no statistically significant difference was found between the two groups in terms of age or gender distribution. Median (range) spot urinary NGAL (u-NGAL) values in the IR group were significantly higher at 26.35 (7.01-108.7) ng/mL than in the control group at 19.5 (3.45-88.14) ng/mL (p=0.018). NGAL/Cr ratio was also significantly higher in the IR group compared to the control group (p=0.018).Conclusion:Obese pediatric patients with IR were shown to have elevated levels of u-NGAL, a marker of renal injury. u-NGAL examination may show early renal injury before development of diabetes.Semra ŞenDeniz Özalp KızılayFatma TaneliÇınar ÖzenPelin Ertanİpek ÖzunanRaziye YıldızBetül ErsoyGalenos Yayincilikarticlengalrenal injurychildkim-1insulin resistancePediatricsRJ1-570Diseases of the endocrine glands. Clinical endocrinologyRC648-665ENJCRPE, Vol 13, Iss 4, Pp 400-407 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	ngal renal injury child kim-1 insulin resistance Pediatrics RJ1-570 Diseases of the endocrine glands. Clinical endocrinology RC648-665
spellingShingle	ngal renal injury child kim-1 insulin resistance Pediatrics RJ1-570 Diseases of the endocrine glands. Clinical endocrinology RC648-665 Semra Şen Deniz Özalp Kızılay Fatma Taneli Çınar Özen Pelin Ertan İpek Özunan Raziye Yıldız Betül Ersoy Urinary NGAL is a Potential Biomarker for Early Renal Injury in Insulin Resistant Obese Non-diabetic Children
description	Objective:Neutrophil gelatinase-associated lipocalin (NGAL) is one of the new biomarkers for detecting acute renal injury. There are studies showing the relationship between NGAL and renal injury in obese children. The aim of this study was to investigate whether urinary levels of NGAL, kidney injury molecule-1, and serum cystatin C are increased in insulin resistance (IR) patients before the development of diabetes.Methods:Cross-sectional, case-controlled study that included non-diabetic obese children and adolescent patients with IR and a nondiabetic obese control group with no IR, who attended a tertiary center pediatric endocrinology outpatient clinic between 2016-2018. Those with diabetes mellitus and/or known renal disease were excluded. NGAL and creatinine (Cr) levels were evaluated in the morning spot urine from all participants. Serum renal function was evaluated.Results:Thirty-six control and 63 IR patients were included in the study, of whom 68 (68.7%) were girls. The mean age of all participants was 13.12±2.64 years and no statistically significant difference was found between the two groups in terms of age or gender distribution. Median (range) spot urinary NGAL (u-NGAL) values in the IR group were significantly higher at 26.35 (7.01-108.7) ng/mL than in the control group at 19.5 (3.45-88.14) ng/mL (p=0.018). NGAL/Cr ratio was also significantly higher in the IR group compared to the control group (p=0.018).Conclusion:Obese pediatric patients with IR were shown to have elevated levels of u-NGAL, a marker of renal injury. u-NGAL examination may show early renal injury before development of diabetes.
format	article
author	Semra Şen Deniz Özalp Kızılay Fatma Taneli Çınar Özen Pelin Ertan İpek Özunan Raziye Yıldız Betül Ersoy
author_facet	Semra Şen Deniz Özalp Kızılay Fatma Taneli Çınar Özen Pelin Ertan İpek Özunan Raziye Yıldız Betül Ersoy
author_sort	Semra Şen
title	Urinary NGAL is a Potential Biomarker for Early Renal Injury in Insulin Resistant Obese Non-diabetic Children
title_short	Urinary NGAL is a Potential Biomarker for Early Renal Injury in Insulin Resistant Obese Non-diabetic Children
title_full	Urinary NGAL is a Potential Biomarker for Early Renal Injury in Insulin Resistant Obese Non-diabetic Children
title_fullStr	Urinary NGAL is a Potential Biomarker for Early Renal Injury in Insulin Resistant Obese Non-diabetic Children
title_full_unstemmed	Urinary NGAL is a Potential Biomarker for Early Renal Injury in Insulin Resistant Obese Non-diabetic Children
title_sort	urinary ngal is a potential biomarker for early renal injury in insulin resistant obese non-diabetic children
publisher	Galenos Yayincilik
publishDate	2021
url	https://doaj.org/article/01b24f4a1e7145d1b71c6be0c7d873bb
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Urinary NGAL is a Potential Biomarker for Early Renal Injury in Insulin Resistant Obese Non-diabetic Children

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