FREQUENCY OF NON-ALCOHOLIC FATTY LIVER DISEASE IN NEWLY DIAGNOSED CASES OF HEPATITIS C VIRUS INFECTION AND ITS CORRELATION WITH GENOTYPES IN NORMAL WEIGHT PATIENTS

Objective: To determine the frequency of non-alcoholic fatty liver disease (NAFLD) in newly diagnosed cases of hepatitis C virus (HCV) infection and its association with genotypes in normal weight patients. Study Design: Descriptive cross-sectional study. Place and Duration of Study: Departments...

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Autores principales:	Sultan Mehmood Kamran, Mobeen Ahmad, Saeed Bin Ayaz, Ijaz Ahmad
Formato:	article
Lenguaje:	EN
Publicado:	Army Medical College Rawalpindi 2018
Materias:	genotype hepatitis c virus Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/01b28585bfa84ad09056f29b28a41334
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spelling	oai:doaj.org-article:01b28585bfa84ad09056f29b28a413342021-12-03T03:20:54ZFREQUENCY OF NON-ALCOHOLIC FATTY LIVER DISEASE IN NEWLY DIAGNOSED CASES OF HEPATITIS C VIRUS INFECTION AND ITS CORRELATION WITH GENOTYPES IN NORMAL WEIGHT PATIENTS0030-96482411-8842https://doaj.org/article/01b28585bfa84ad09056f29b28a413342018-10-01T00:00:00Zhttps://www.pafmj.org/index.php/PAFMJ/article/view/2344/2031https://doaj.org/toc/0030-9648https://doaj.org/toc/2411-8842Objective: To determine the frequency of non-alcoholic fatty liver disease (NAFLD) in newly diagnosed cases of hepatitis C virus (HCV) infection and its association with genotypes in normal weight patients. Study Design: Descriptive cross-sectional study. Place and Duration of Study: Departments of internal medicine and diagnostic imaging, Combined Military Hospital Okara, from Oct 2013 to Mar 2014. Material and Methods: We included 211 patients from Okara through consecutive sampling who were found positive for anti HCV antibodies and HCV RNA after informed consent. The sampled patients were evaluated for liver echotexture through ultrasonography and genotype analysis by polymerase chain reaction. Variables were defined qualitatively and quantitatively and frequencies, percentages, means, and standard deviations were calculated. For the association of ultrasonographic findings with the genotypes, Pearson’s Chi-square or Fischer’s exact tests were applied where appropriate. All the data were analyzed using statistical package for social sciences version 20. A p-value <0.05 was considered significant. Results: The mean age was 32 ± 6 years with a range of 21 ± 47 years. Most (85.3%, n=180) were married. The majority (62.1%, n=131) hailed from the Punjab province and from the age-group of ≤32 years (55.9%, n=118). The findings seen on ultrasonography were normal echotexture in 93 (44.1%), NAFLD in 112 (53.1%), and chronic liver disease in 6 (2.8%) individuals. NAFLD was commonest among HCV RNA genotype 3 positive cases. Conclusion: Fifty-three percent patients with positive HCV RNA had NAFLD identified on ultrasonographic examination. The genotype 3 of HCV RNA was particularly affiliated with NAFLD.Sultan Mehmood KamranMobeen AhmadSaeed Bin AyazIjaz AhmadArmy Medical College Rawalpindiarticlegenotypehepatitis c virusMedicineRMedicine (General)R5-920ENPakistan Armed Forces Medical Journal, Vol 68, Iss 5, Pp 1444-1448 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	genotype hepatitis c virus Medicine R Medicine (General) R5-920
spellingShingle	genotype hepatitis c virus Medicine R Medicine (General) R5-920 Sultan Mehmood Kamran Mobeen Ahmad Saeed Bin Ayaz Ijaz Ahmad FREQUENCY OF NON-ALCOHOLIC FATTY LIVER DISEASE IN NEWLY DIAGNOSED CASES OF HEPATITIS C VIRUS INFECTION AND ITS CORRELATION WITH GENOTYPES IN NORMAL WEIGHT PATIENTS
description	Objective: To determine the frequency of non-alcoholic fatty liver disease (NAFLD) in newly diagnosed cases of hepatitis C virus (HCV) infection and its association with genotypes in normal weight patients. Study Design: Descriptive cross-sectional study. Place and Duration of Study: Departments of internal medicine and diagnostic imaging, Combined Military Hospital Okara, from Oct 2013 to Mar 2014. Material and Methods: We included 211 patients from Okara through consecutive sampling who were found positive for anti HCV antibodies and HCV RNA after informed consent. The sampled patients were evaluated for liver echotexture through ultrasonography and genotype analysis by polymerase chain reaction. Variables were defined qualitatively and quantitatively and frequencies, percentages, means, and standard deviations were calculated. For the association of ultrasonographic findings with the genotypes, Pearson’s Chi-square or Fischer’s exact tests were applied where appropriate. All the data were analyzed using statistical package for social sciences version 20. A p-value <0.05 was considered significant. Results: The mean age was 32 ± 6 years with a range of 21 ± 47 years. Most (85.3%, n=180) were married. The majority (62.1%, n=131) hailed from the Punjab province and from the age-group of ≤32 years (55.9%, n=118). The findings seen on ultrasonography were normal echotexture in 93 (44.1%), NAFLD in 112 (53.1%), and chronic liver disease in 6 (2.8%) individuals. NAFLD was commonest among HCV RNA genotype 3 positive cases. Conclusion: Fifty-three percent patients with positive HCV RNA had NAFLD identified on ultrasonographic examination. The genotype 3 of HCV RNA was particularly affiliated with NAFLD.
format	article
author	Sultan Mehmood Kamran Mobeen Ahmad Saeed Bin Ayaz Ijaz Ahmad
author_facet	Sultan Mehmood Kamran Mobeen Ahmad Saeed Bin Ayaz Ijaz Ahmad
author_sort	Sultan Mehmood Kamran
title	FREQUENCY OF NON-ALCOHOLIC FATTY LIVER DISEASE IN NEWLY DIAGNOSED CASES OF HEPATITIS C VIRUS INFECTION AND ITS CORRELATION WITH GENOTYPES IN NORMAL WEIGHT PATIENTS
title_short	FREQUENCY OF NON-ALCOHOLIC FATTY LIVER DISEASE IN NEWLY DIAGNOSED CASES OF HEPATITIS C VIRUS INFECTION AND ITS CORRELATION WITH GENOTYPES IN NORMAL WEIGHT PATIENTS
title_full	FREQUENCY OF NON-ALCOHOLIC FATTY LIVER DISEASE IN NEWLY DIAGNOSED CASES OF HEPATITIS C VIRUS INFECTION AND ITS CORRELATION WITH GENOTYPES IN NORMAL WEIGHT PATIENTS
title_fullStr	FREQUENCY OF NON-ALCOHOLIC FATTY LIVER DISEASE IN NEWLY DIAGNOSED CASES OF HEPATITIS C VIRUS INFECTION AND ITS CORRELATION WITH GENOTYPES IN NORMAL WEIGHT PATIENTS
title_full_unstemmed	FREQUENCY OF NON-ALCOHOLIC FATTY LIVER DISEASE IN NEWLY DIAGNOSED CASES OF HEPATITIS C VIRUS INFECTION AND ITS CORRELATION WITH GENOTYPES IN NORMAL WEIGHT PATIENTS
title_sort	frequency of non-alcoholic fatty liver disease in newly diagnosed cases of hepatitis c virus infection and its correlation with genotypes in normal weight patients
publisher	Army Medical College Rawalpindi
publishDate	2018
url	https://doaj.org/article/01b28585bfa84ad09056f29b28a41334
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FREQUENCY OF NON-ALCOHOLIC FATTY LIVER DISEASE IN NEWLY DIAGNOSED CASES OF HEPATITIS C VIRUS INFECTION AND ITS CORRELATION WITH GENOTYPES IN NORMAL WEIGHT PATIENTS

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