Different Ability of Multidrug-Resistant and -Sensitive Counterpart Cells to Release and Capture Extracellular Vesicles

Cancer multidrug resistance (MDR) is one of the main challenges for cancer treatment efficacy. MDR is a phenomenon by which tumor cells become resistant to several unrelated drugs. Some studies have previously described the important role of extracellular vesicles (EVs) in the dissemination of a MDR...

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Autores principales:	Diana Sousa, Raquel T. Lima, Vanessa Lopes-Rodrigues, Esperanza Gonzalez, Félix Royo, Cristina P. R. Xavier, Juan M. Falcón-Pérez, M. Helena Vasconcelos
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	cancer multidrug resistance extracellular vesicles endocytic pathway Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/01b5a413fe0b4809824b535a8a1e72cf
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spelling	oai:doaj.org-article:01b5a413fe0b4809824b535a8a1e72cf2021-11-25T17:08:33ZDifferent Ability of Multidrug-Resistant and -Sensitive Counterpart Cells to Release and Capture Extracellular Vesicles10.3390/cells101128862073-4409https://doaj.org/article/01b5a413fe0b4809824b535a8a1e72cf2021-10-01T00:00:00Zhttps://www.mdpi.com/2073-4409/10/11/2886https://doaj.org/toc/2073-4409Cancer multidrug resistance (MDR) is one of the main challenges for cancer treatment efficacy. MDR is a phenomenon by which tumor cells become resistant to several unrelated drugs. Some studies have previously described the important role of extracellular vesicles (EVs) in the dissemination of a MDR phenotype. EVs’ cargo may include different players of MDR, such as microRNAS and drug-efflux pumps, which may be transferred from donor MDR cells to recipient drug-sensitive counterparts. The present work aimed to: (i) compare the ability of drug-sensitive and their MDR counterpart cells to release and capture EVs and (ii) study and relate those differences with possible distinct fate of the endocytic pathway in these counterpart cells. Our results showed that MDR cells released more EVs than their drug-sensitive counterparts and also that the drug-sensitive cells captured more EVs than their MDR counterparts. This difference in the release and capture of EVs may be associated with differences in the endocytic pathway between drug-sensitive and MDR cells. Importantly, manipulation of the recycling pathway influenced the response of drug-sensitive cells to doxorubicin treatment.Diana SousaRaquel T. LimaVanessa Lopes-RodriguesEsperanza GonzalezFélix RoyoCristina P. R. XavierJuan M. Falcón-PérezM. Helena VasconcelosMDPI AGarticlecancer multidrug resistanceextracellular vesiclesendocytic pathwayBiology (General)QH301-705.5ENCells, Vol 10, Iss 2886, p 2886 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cancer multidrug resistance extracellular vesicles endocytic pathway Biology (General) QH301-705.5
spellingShingle	cancer multidrug resistance extracellular vesicles endocytic pathway Biology (General) QH301-705.5 Diana Sousa Raquel T. Lima Vanessa Lopes-Rodrigues Esperanza Gonzalez Félix Royo Cristina P. R. Xavier Juan M. Falcón-Pérez M. Helena Vasconcelos Different Ability of Multidrug-Resistant and -Sensitive Counterpart Cells to Release and Capture Extracellular Vesicles
description	Cancer multidrug resistance (MDR) is one of the main challenges for cancer treatment efficacy. MDR is a phenomenon by which tumor cells become resistant to several unrelated drugs. Some studies have previously described the important role of extracellular vesicles (EVs) in the dissemination of a MDR phenotype. EVs’ cargo may include different players of MDR, such as microRNAS and drug-efflux pumps, which may be transferred from donor MDR cells to recipient drug-sensitive counterparts. The present work aimed to: (i) compare the ability of drug-sensitive and their MDR counterpart cells to release and capture EVs and (ii) study and relate those differences with possible distinct fate of the endocytic pathway in these counterpart cells. Our results showed that MDR cells released more EVs than their drug-sensitive counterparts and also that the drug-sensitive cells captured more EVs than their MDR counterparts. This difference in the release and capture of EVs may be associated with differences in the endocytic pathway between drug-sensitive and MDR cells. Importantly, manipulation of the recycling pathway influenced the response of drug-sensitive cells to doxorubicin treatment.
format	article
author	Diana Sousa Raquel T. Lima Vanessa Lopes-Rodrigues Esperanza Gonzalez Félix Royo Cristina P. R. Xavier Juan M. Falcón-Pérez M. Helena Vasconcelos
author_facet	Diana Sousa Raquel T. Lima Vanessa Lopes-Rodrigues Esperanza Gonzalez Félix Royo Cristina P. R. Xavier Juan M. Falcón-Pérez M. Helena Vasconcelos
author_sort	Diana Sousa
title	Different Ability of Multidrug-Resistant and -Sensitive Counterpart Cells to Release and Capture Extracellular Vesicles
title_short	Different Ability of Multidrug-Resistant and -Sensitive Counterpart Cells to Release and Capture Extracellular Vesicles
title_full	Different Ability of Multidrug-Resistant and -Sensitive Counterpart Cells to Release and Capture Extracellular Vesicles
title_fullStr	Different Ability of Multidrug-Resistant and -Sensitive Counterpart Cells to Release and Capture Extracellular Vesicles
title_full_unstemmed	Different Ability of Multidrug-Resistant and -Sensitive Counterpart Cells to Release and Capture Extracellular Vesicles
title_sort	different ability of multidrug-resistant and -sensitive counterpart cells to release and capture extracellular vesicles
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/01b5a413fe0b4809824b535a8a1e72cf
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Different Ability of Multidrug-Resistant and -Sensitive Counterpart Cells to Release and Capture Extracellular Vesicles

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