Measurement of stretch-evoked brainstem function using fMRI

Abstract Knowledge on the organization of motor function in the reticulospinal tract (RST) is limited by the lack of methods for measuring RST function in humans. Behavioral studies suggest the involvement of the RST in long latency responses (LLRs). LLRs, elicited by precisely controlled perturbati...

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Autores principales:	Andrea Zonnino, Andria J. Farrens, David Ress, Fabrizio Sergi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/01b668478988480e86891f4d7f7c805b
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spelling	oai:doaj.org-article:01b668478988480e86891f4d7f7c805b2021-12-02T16:04:22ZMeasurement of stretch-evoked brainstem function using fMRI10.1038/s41598-021-91605-52045-2322https://doaj.org/article/01b668478988480e86891f4d7f7c805b2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-91605-5https://doaj.org/toc/2045-2322Abstract Knowledge on the organization of motor function in the reticulospinal tract (RST) is limited by the lack of methods for measuring RST function in humans. Behavioral studies suggest the involvement of the RST in long latency responses (LLRs). LLRs, elicited by precisely controlled perturbations, can therefore act as a viable paradigm to measure motor-related RST activity using functional Magnetic Resonance Imaging (fMRI). Here we present StretchfMRI, a novel technique developed to study RST function associated with LLRs. StretchfMRI combines robotic perturbations with electromyography and fMRI to simultaneously quantify muscular and neural activity during stretch-evoked LLRs without loss of reliability. Using StretchfMRI, we established the muscle-specific organization of LLR activity in the brainstem. The observed organization is partially consistent with animal models, with activity primarily in the ipsilateral medulla for flexors and in the contralateral pons for extensors, but also includes other areas, such as the midbrain and bilateral pontomedullary contributions.Andrea ZonninoAndria J. FarrensDavid RessFabrizio SergiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-21 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Andrea Zonnino Andria J. Farrens David Ress Fabrizio Sergi Measurement of stretch-evoked brainstem function using fMRI
description	Abstract Knowledge on the organization of motor function in the reticulospinal tract (RST) is limited by the lack of methods for measuring RST function in humans. Behavioral studies suggest the involvement of the RST in long latency responses (LLRs). LLRs, elicited by precisely controlled perturbations, can therefore act as a viable paradigm to measure motor-related RST activity using functional Magnetic Resonance Imaging (fMRI). Here we present StretchfMRI, a novel technique developed to study RST function associated with LLRs. StretchfMRI combines robotic perturbations with electromyography and fMRI to simultaneously quantify muscular and neural activity during stretch-evoked LLRs without loss of reliability. Using StretchfMRI, we established the muscle-specific organization of LLR activity in the brainstem. The observed organization is partially consistent with animal models, with activity primarily in the ipsilateral medulla for flexors and in the contralateral pons for extensors, but also includes other areas, such as the midbrain and bilateral pontomedullary contributions.
format	article
author	Andrea Zonnino Andria J. Farrens David Ress Fabrizio Sergi
author_facet	Andrea Zonnino Andria J. Farrens David Ress Fabrizio Sergi
author_sort	Andrea Zonnino
title	Measurement of stretch-evoked brainstem function using fMRI
title_short	Measurement of stretch-evoked brainstem function using fMRI
title_full	Measurement of stretch-evoked brainstem function using fMRI
title_fullStr	Measurement of stretch-evoked brainstem function using fMRI
title_full_unstemmed	Measurement of stretch-evoked brainstem function using fMRI
title_sort	measurement of stretch-evoked brainstem function using fmri
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/01b668478988480e86891f4d7f7c805b
work_keys_str_mv	AT andreazonnino measurementofstretchevokedbrainstemfunctionusingfmri AT andriajfarrens measurementofstretchevokedbrainstemfunctionusingfmri AT davidress measurementofstretchevokedbrainstemfunctionusingfmri AT fabriziosergi measurementofstretchevokedbrainstemfunctionusingfmri
_version_	1718385188081238016

Measurement of stretch-evoked brainstem function using fMRI

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