Mutational robustness of gene regulatory networks.

Mutational robustness of gene regulatory networks refers to their ability to generate constant biological output upon mutations that change network structure. Such networks contain regulatory interactions (transcription factor-target gene interactions) but often also protein-protein interactions bet...

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Autores principales:	Aalt D J van Dijk, Simon van Mourik, Roeland C H J van Ham
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/01bb09ed88bb42f0a1953deeb22cc87d
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spelling	oai:doaj.org-article:01bb09ed88bb42f0a1953deeb22cc87d2021-11-18T07:29:21ZMutational robustness of gene regulatory networks.1932-620310.1371/journal.pone.0030591https://doaj.org/article/01bb09ed88bb42f0a1953deeb22cc87d2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22295094/?tool=EBIhttps://doaj.org/toc/1932-6203Mutational robustness of gene regulatory networks refers to their ability to generate constant biological output upon mutations that change network structure. Such networks contain regulatory interactions (transcription factor-target gene interactions) but often also protein-protein interactions between transcription factors. Using computational modeling, we study factors that influence robustness and we infer several network properties governing it. These include the type of mutation, i.e. whether a regulatory interaction or a protein-protein interaction is mutated, and in the case of mutation of a regulatory interaction, the sign of the interaction (activating vs. repressive). In addition, we analyze the effect of combinations of mutations and we compare networks containing monomeric with those containing dimeric transcription factors. Our results are consistent with available data on biological networks, for example based on evolutionary conservation of network features. As a novel and remarkable property, we predict that networks are more robust against mutations in monomer than in dimer transcription factors, a prediction for which analysis of conservation of DNA binding residues in monomeric vs. dimeric transcription factors provides indirect evidence.Aalt D J van DijkSimon van MourikRoeland C H J van HamPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 1, p e30591 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Aalt D J van Dijk Simon van Mourik Roeland C H J van Ham Mutational robustness of gene regulatory networks.
description	Mutational robustness of gene regulatory networks refers to their ability to generate constant biological output upon mutations that change network structure. Such networks contain regulatory interactions (transcription factor-target gene interactions) but often also protein-protein interactions between transcription factors. Using computational modeling, we study factors that influence robustness and we infer several network properties governing it. These include the type of mutation, i.e. whether a regulatory interaction or a protein-protein interaction is mutated, and in the case of mutation of a regulatory interaction, the sign of the interaction (activating vs. repressive). In addition, we analyze the effect of combinations of mutations and we compare networks containing monomeric with those containing dimeric transcription factors. Our results are consistent with available data on biological networks, for example based on evolutionary conservation of network features. As a novel and remarkable property, we predict that networks are more robust against mutations in monomer than in dimer transcription factors, a prediction for which analysis of conservation of DNA binding residues in monomeric vs. dimeric transcription factors provides indirect evidence.
format	article
author	Aalt D J van Dijk Simon van Mourik Roeland C H J van Ham
author_facet	Aalt D J van Dijk Simon van Mourik Roeland C H J van Ham
author_sort	Aalt D J van Dijk
title	Mutational robustness of gene regulatory networks.
title_short	Mutational robustness of gene regulatory networks.
title_full	Mutational robustness of gene regulatory networks.
title_fullStr	Mutational robustness of gene regulatory networks.
title_full_unstemmed	Mutational robustness of gene regulatory networks.
title_sort	mutational robustness of gene regulatory networks.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/01bb09ed88bb42f0a1953deeb22cc87d
work_keys_str_mv	AT aaltdjvandijk mutationalrobustnessofgeneregulatorynetworks AT simonvanmourik mutationalrobustnessofgeneregulatorynetworks AT roelandchjvanham mutationalrobustnessofgeneregulatorynetworks
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Mutational robustness of gene regulatory networks.

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