Zeta Inhibitory Peptide attenuates learning and memory by inducing NO-mediated downregulation of AMPA receptors

Zeta inhibitory peptide (ZIP) impairs the maintenance of acquired memories. ZIP is known as an inhibitor of PKMζ. Here, the authors unveil how ZIP impairs memory maintenance acting as an arginine donor, facilitating NO-dependent down-regulation of AMPARs, independently of its action on PKMζ.

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Autores principales:	Alexey Bingor, Tomer Haham, Claire Thornton, Yael Stern-Bach, Rami Yaka
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/01bc7875739f4b9686cb40eec93d2553
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spelling	oai:doaj.org-article:01bc7875739f4b9686cb40eec93d25532021-12-02T17:57:17ZZeta Inhibitory Peptide attenuates learning and memory by inducing NO-mediated downregulation of AMPA receptors10.1038/s41467-020-17484-y2041-1723https://doaj.org/article/01bc7875739f4b9686cb40eec93d25532020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17484-yhttps://doaj.org/toc/2041-1723Zeta inhibitory peptide (ZIP) impairs the maintenance of acquired memories. ZIP is known as an inhibitor of PKMζ. Here, the authors unveil how ZIP impairs memory maintenance acting as an arginine donor, facilitating NO-dependent down-regulation of AMPARs, independently of its action on PKMζ.Alexey BingorTomer HahamClaire ThorntonYael Stern-BachRami YakaNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Alexey Bingor Tomer Haham Claire Thornton Yael Stern-Bach Rami Yaka Zeta Inhibitory Peptide attenuates learning and memory by inducing NO-mediated downregulation of AMPA receptors
description	Zeta inhibitory peptide (ZIP) impairs the maintenance of acquired memories. ZIP is known as an inhibitor of PKMζ. Here, the authors unveil how ZIP impairs memory maintenance acting as an arginine donor, facilitating NO-dependent down-regulation of AMPARs, independently of its action on PKMζ.
format	article
author	Alexey Bingor Tomer Haham Claire Thornton Yael Stern-Bach Rami Yaka
author_facet	Alexey Bingor Tomer Haham Claire Thornton Yael Stern-Bach Rami Yaka
author_sort	Alexey Bingor
title	Zeta Inhibitory Peptide attenuates learning and memory by inducing NO-mediated downregulation of AMPA receptors
title_short	Zeta Inhibitory Peptide attenuates learning and memory by inducing NO-mediated downregulation of AMPA receptors
title_full	Zeta Inhibitory Peptide attenuates learning and memory by inducing NO-mediated downregulation of AMPA receptors
title_fullStr	Zeta Inhibitory Peptide attenuates learning and memory by inducing NO-mediated downregulation of AMPA receptors
title_full_unstemmed	Zeta Inhibitory Peptide attenuates learning and memory by inducing NO-mediated downregulation of AMPA receptors
title_sort	zeta inhibitory peptide attenuates learning and memory by inducing no-mediated downregulation of ampa receptors
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/01bc7875739f4b9686cb40eec93d2553
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Zeta Inhibitory Peptide attenuates learning and memory by inducing NO-mediated downregulation of AMPA receptors

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