EAF2 mediates germinal centre B-cell apoptosis to suppress excessive immune responses and prevent autoimmunity

EAF2 has been previously known as a transcriptional elongation factor and a proapoptotic gene lost in prostate cancer. Here the authors show that EAF2 is required for apoptosis of germinal centre B cells, and that EAF2-deficient mice develop excessive antibody responses and autoimmunity.

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Autores principales:	Yingqian Li, Yoshimasa Takahashi, Shin-ichiro Fujii, Yang Zhou, Rongjian Hong, Akari Suzuki, Takeshi Tsubata, Koji Hase, Ji-Yang Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/01bd65f796e8492f932b77a49da26010
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spelling	oai:doaj.org-article:01bd65f796e8492f932b77a49da260102021-12-02T17:32:22ZEAF2 mediates germinal centre B-cell apoptosis to suppress excessive immune responses and prevent autoimmunity10.1038/ncomms108362041-1723https://doaj.org/article/01bd65f796e8492f932b77a49da260102016-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms10836https://doaj.org/toc/2041-1723EAF2 has been previously known as a transcriptional elongation factor and a proapoptotic gene lost in prostate cancer. Here the authors show that EAF2 is required for apoptosis of germinal centre B cells, and that EAF2-deficient mice develop excessive antibody responses and autoimmunity.Yingqian LiYoshimasa TakahashiShin-ichiro FujiiYang ZhouRongjian HongAkari SuzukiTakeshi TsubataKoji HaseJi-Yang WangNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yingqian Li Yoshimasa Takahashi Shin-ichiro Fujii Yang Zhou Rongjian Hong Akari Suzuki Takeshi Tsubata Koji Hase Ji-Yang Wang EAF2 mediates germinal centre B-cell apoptosis to suppress excessive immune responses and prevent autoimmunity
description	EAF2 has been previously known as a transcriptional elongation factor and a proapoptotic gene lost in prostate cancer. Here the authors show that EAF2 is required for apoptosis of germinal centre B cells, and that EAF2-deficient mice develop excessive antibody responses and autoimmunity.
format	article
author	Yingqian Li Yoshimasa Takahashi Shin-ichiro Fujii Yang Zhou Rongjian Hong Akari Suzuki Takeshi Tsubata Koji Hase Ji-Yang Wang
author_facet	Yingqian Li Yoshimasa Takahashi Shin-ichiro Fujii Yang Zhou Rongjian Hong Akari Suzuki Takeshi Tsubata Koji Hase Ji-Yang Wang
author_sort	Yingqian Li
title	EAF2 mediates germinal centre B-cell apoptosis to suppress excessive immune responses and prevent autoimmunity
title_short	EAF2 mediates germinal centre B-cell apoptosis to suppress excessive immune responses and prevent autoimmunity
title_full	EAF2 mediates germinal centre B-cell apoptosis to suppress excessive immune responses and prevent autoimmunity
title_fullStr	EAF2 mediates germinal centre B-cell apoptosis to suppress excessive immune responses and prevent autoimmunity
title_full_unstemmed	EAF2 mediates germinal centre B-cell apoptosis to suppress excessive immune responses and prevent autoimmunity
title_sort	eaf2 mediates germinal centre b-cell apoptosis to suppress excessive immune responses and prevent autoimmunity
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/01bd65f796e8492f932b77a49da26010
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EAF2 mediates germinal centre B-cell apoptosis to suppress excessive immune responses and prevent autoimmunity

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