Murine models for studying immunopathogenesis in gastrointestinal lesions: How to go about it

Gastro-intestinal (GI) lesions are common outcome to diverse etiological agents affecting the GI tract. It requires significant expertise to accurately diagnose the fundamental cause and treat accordingly. A better understanding of the immunological underpinning of these lesions is of great importan...

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Autores principales:	Neharika Jain, Priya Sharma, Dhiraj Kumar
Formato:	article
Lenguaje:	EN
Publicado:	Wolters Kluwer Medknow Publications 2021
Materias:	ibd murine model non-human primates Pathology RB1-214 Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/01be5ebcf5a8456397f8515d9ebcb18d
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spelling	oai:doaj.org-article:01be5ebcf5a8456397f8515d9ebcb18d2021-12-02T19:27:26ZMurine models for studying immunopathogenesis in gastrointestinal lesions: How to go about it0377-492910.4103/IJPM.IJPM_802_20https://doaj.org/article/01be5ebcf5a8456397f8515d9ebcb18d2021-01-01T00:00:00Zhttp://www.ijpmonline.org/article.asp?issn=0377-4929;year=2021;volume=64;issue=5;spage=58;epage=62;aulast=Jainhttps://doaj.org/toc/0377-4929Gastro-intestinal (GI) lesions are common outcome to diverse etiological agents affecting the GI tract. It requires significant expertise to accurately diagnose the fundamental cause and treat accordingly. A better understanding of the immunological underpinning of these lesions is of great importance to ensure their successful management. Availability of specific animal models allows us to understand the subtle differences among diverse disease conditions and help decide upon the treatment trajectories. Since murine models are best suited for studying the immunopathogenesis of any disease, we will restrict our discussions here to the available murine models and their applications to study gastrointestinal lesions. In this review, we have systematically examined and compared the variety of mice models that are routinely used to study Inflammatory Bowel disease (IBD) and also how they can be leveraged to address specific questions relating to IBD.Neharika JainPriya SharmaDhiraj KumarWolters Kluwer Medknow Publicationsarticleibdmurine modelnon-human primatesPathologyRB1-214MicrobiologyQR1-502ENIndian Journal of Pathology and Microbiology, Vol 64, Iss 5, Pp 58-62 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	ibd murine model non-human primates Pathology RB1-214 Microbiology QR1-502
spellingShingle	ibd murine model non-human primates Pathology RB1-214 Microbiology QR1-502 Neharika Jain Priya Sharma Dhiraj Kumar Murine models for studying immunopathogenesis in gastrointestinal lesions: How to go about it
description	Gastro-intestinal (GI) lesions are common outcome to diverse etiological agents affecting the GI tract. It requires significant expertise to accurately diagnose the fundamental cause and treat accordingly. A better understanding of the immunological underpinning of these lesions is of great importance to ensure their successful management. Availability of specific animal models allows us to understand the subtle differences among diverse disease conditions and help decide upon the treatment trajectories. Since murine models are best suited for studying the immunopathogenesis of any disease, we will restrict our discussions here to the available murine models and their applications to study gastrointestinal lesions. In this review, we have systematically examined and compared the variety of mice models that are routinely used to study Inflammatory Bowel disease (IBD) and also how they can be leveraged to address specific questions relating to IBD.
format	article
author	Neharika Jain Priya Sharma Dhiraj Kumar
author_facet	Neharika Jain Priya Sharma Dhiraj Kumar
author_sort	Neharika Jain
title	Murine models for studying immunopathogenesis in gastrointestinal lesions: How to go about it
title_short	Murine models for studying immunopathogenesis in gastrointestinal lesions: How to go about it
title_full	Murine models for studying immunopathogenesis in gastrointestinal lesions: How to go about it
title_fullStr	Murine models for studying immunopathogenesis in gastrointestinal lesions: How to go about it
title_full_unstemmed	Murine models for studying immunopathogenesis in gastrointestinal lesions: How to go about it
title_sort	murine models for studying immunopathogenesis in gastrointestinal lesions: how to go about it
publisher	Wolters Kluwer Medknow Publications
publishDate	2021
url	https://doaj.org/article/01be5ebcf5a8456397f8515d9ebcb18d
work_keys_str_mv	AT neharikajain murinemodelsforstudyingimmunopathogenesisingastrointestinallesionshowtogoaboutit AT priyasharma murinemodelsforstudyingimmunopathogenesisingastrointestinallesionshowtogoaboutit AT dhirajkumar murinemodelsforstudyingimmunopathogenesisingastrointestinallesionshowtogoaboutit
_version_	1718376476818014208

Murine models for studying immunopathogenesis in gastrointestinal lesions: How to go about it

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