Plant AtEH/Pan1 proteins drive autophagosome formation at ER-PM contact sites with actin and endocytic machinery

Plant AtEH/Pan1 proteins drive autophagosome formation at ER-PM contact sites with actin and endocytic machinery

Arabidopsis EH/Pan1 proteins are part of the TPLATE complex (TPC) that is required for endocytosis in plants. Here, the authors show AtEH/Pan1 proteins also act in actin-mediated autophagy, by interacting with VAP27-1 at ER-PM contact sites and recruiting TPLATE and AP-2 complex subunits, clathrin a...

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Main Authors: Pengwei Wang, Roman Pleskot, Jingze Zang, Joanna Winkler, Jie Wang, Klaas Yperman, Tong Zhang, Kun Wang, Jinli Gong, Yajie Guan, Christine Richardson, Patrick Duckney, Michael Vandorpe, Evelien Mylle, Jindriska Fiserova, Daniel Van Damme, Patrick J. Hussey
Format: article
Language:EN
Published: Nature Portfolio 2019
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Science
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Online Access:https://doaj.org/article/01c2b27c790548469d911b8b18a076e0
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Summary:Arabidopsis EH/Pan1 proteins are part of the TPLATE complex (TPC) that is required for endocytosis in plants. Here, the authors show AtEH/Pan1 proteins also act in actin-mediated autophagy, by interacting with VAP27-1 at ER-PM contact sites and recruiting TPLATE and AP-2 complex subunits, clathrin and ARP2/3/ proteins to autophagosomes.

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