Burgeoning Polymer Nano Blends for Improved Controlled Drug Release: A Review

Saeid Maghsoudi,1 Bahareh Taghavi Shahraki,1 Navid Rabiee,2 Yousef Fatahi,3– 5 Rassoul Dinarvand,3,4 Maryam Tavakolizadeh,6 Sepideh Ahmadi,7,8 Mohammad Rabiee,9 Mojtaba Bagherzadeh,2 Ali Pourjavadi,6 Hassan Farhadnejad,10 Mohammadreza Tahriri,11 Thomas J Webster,12 Lobat Tayebi11 1Departme...

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Autores principales:	Maghsoudi S, Taghavi Shahraki B, Rabiee N, Fatahi Y, Dinarvand R, Tavakolizadeh M, Ahmadi S, Rabiee M, Bagherzadeh M, Pourjavadi A, Farhadnejad H, Tahriri M, Webster TJ, Tayebi L
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	polymer blends drug delivery wound dressing plga chitosan starch Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/01c2ceda2e2d45ffaf77d501376d8116
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id	oai:doaj.org-article:01c2ceda2e2d45ffaf77d501376d8116
record_format	dspace
institution	DOAJ
collection	DOAJ
language	EN
topic	polymer blends drug delivery wound dressing plga chitosan starch Medicine (General) R5-920
spellingShingle	polymer blends drug delivery wound dressing plga chitosan starch Medicine (General) R5-920 Maghsoudi S Taghavi Shahraki B Rabiee N Fatahi Y Dinarvand R Tavakolizadeh M Ahmadi S Rabiee M Bagherzadeh M Pourjavadi A Farhadnejad H Tahriri M Webster TJ Tayebi L Burgeoning Polymer Nano Blends for Improved Controlled Drug Release: A Review
description	Saeid Maghsoudi,1 Bahareh Taghavi Shahraki,1 Navid Rabiee,2 Yousef Fatahi,3– 5 Rassoul Dinarvand,3,4 Maryam Tavakolizadeh,6 Sepideh Ahmadi,7,8 Mohammad Rabiee,9 Mojtaba Bagherzadeh,2 Ali Pourjavadi,6 Hassan Farhadnejad,10 Mohammadreza Tahriri,11 Thomas J Webster,12 Lobat Tayebi11 1Department of Medicinal Chemistry, Shiraz University of Technology, Shiraz, Iran; 2Department of Chemistry, Sharif University of Technology, Tehran, Iran; 3Department of Pharmaceutical Nanotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran; 4Nanotechnology Research Centre, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran; 5Universal Scientific Education and Research Network (USERN), Tehran, Iran; 6Polymer Research Laboratory, Department of Chemistry, Sharif University of Technology, Tehran 11365-9516, Iran; 7Student Research Committee, Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 8Cellular and Molecular Biology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 9Biomaterial Group, Department of Biomedical Engineering, Amirkabir University of Technology, Tehran, Iran; 10Department of Pharmaceutics and Pharmaceutical Nanotechnology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 11School of Dentistry, Marquette University, Milwaukee, WI 53233, USA; 12Department of Chemical Engineering, Northeastern University, Boston, MA 02115, USACorrespondence: Thomas J Webster; Mohammadreza Tahriri Tel +1 617 373 6585Email th.webster@neu.edu; mohammadreza.tahriri@marquette.eduAbstract: With continual rapid developments in the biomedical field and understanding of the important mechanisms and pharmacokinetics of biological molecules, controlled drug delivery systems (CDDSs) have been at the forefront over conventional drug delivery systems. Over the past several years, scientists have placed boundless energy and time into exploiting a wide variety of excipients, particularly diverse polymers, both natural and synthetic. More recently, the development of nano polymer blends has achieved noteworthy attention due to their amazing properties, such as biocompatibility, biodegradability and more importantly, their pivotal role in controlled and sustained drug release in vitro and in vivo. These compounds come with a number of effective benefits for improving problems of targeted or controlled drug and gene delivery systems; thus, they have been extensively used in medical and pharmaceutical applications. Additionally, they are quite attractive for wound dressings, textiles, tissue engineering, and biomedical prostheses. In this sense, some important and workable natural polymers (namely, chitosan (CS), starch and cellulose) and some applicable synthetic ones (such as poly-lactic-co-glycolic acid (PLGA), poly(lactic acid) (PLA) and poly-glycolic acid (PGA)) have played an indispensable role over the last two decades for their therapeutic effects owing to their appealing and renewable biological properties. According to our data, this is the first review article highlighting CDDSs composed of diverse natural and synthetic nano biopolymers, blended for biological purposes, mostly over the past five years; other reviews have just briefly mentioned the use of such blended polymers. We, additionally, try to make comparisons between various nano blending systems in terms of improved sustained and controlled drug release behavior.Keywords: polymer blends, drug delivery, wound dressing, PLGA, chitosan, starch
format	article
author	Maghsoudi S Taghavi Shahraki B Rabiee N Fatahi Y Dinarvand R Tavakolizadeh M Ahmadi S Rabiee M Bagherzadeh M Pourjavadi A Farhadnejad H Tahriri M Webster TJ Tayebi L
author_facet	Maghsoudi S Taghavi Shahraki B Rabiee N Fatahi Y Dinarvand R Tavakolizadeh M Ahmadi S Rabiee M Bagherzadeh M Pourjavadi A Farhadnejad H Tahriri M Webster TJ Tayebi L
author_sort	Maghsoudi S
title	Burgeoning Polymer Nano Blends for Improved Controlled Drug Release: A Review
title_short	Burgeoning Polymer Nano Blends for Improved Controlled Drug Release: A Review
title_full	Burgeoning Polymer Nano Blends for Improved Controlled Drug Release: A Review
title_fullStr	Burgeoning Polymer Nano Blends for Improved Controlled Drug Release: A Review
title_full_unstemmed	Burgeoning Polymer Nano Blends for Improved Controlled Drug Release: A Review
title_sort	burgeoning polymer nano blends for improved controlled drug release: a review
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/01c2ceda2e2d45ffaf77d501376d8116
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spelling	oai:doaj.org-article:01c2ceda2e2d45ffaf77d501376d81162021-12-02T09:34:43ZBurgeoning Polymer Nano Blends for Improved Controlled Drug Release: A Review1178-2013https://doaj.org/article/01c2ceda2e2d45ffaf77d501376d81162020-06-01T00:00:00Zhttps://www.dovepress.com/burgeoning-polymer-nano-blends-for-improved-controlled-drug-release-a--peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Saeid Maghsoudi,1 Bahareh Taghavi Shahraki,1 Navid Rabiee,2 Yousef Fatahi,3– 5 Rassoul Dinarvand,3,4 Maryam Tavakolizadeh,6 Sepideh Ahmadi,7,8 Mohammad Rabiee,9 Mojtaba Bagherzadeh,2 Ali Pourjavadi,6 Hassan Farhadnejad,10 Mohammadreza Tahriri,11 Thomas J Webster,12 Lobat Tayebi11 1Department of Medicinal Chemistry, Shiraz University of Technology, Shiraz, Iran; 2Department of Chemistry, Sharif University of Technology, Tehran, Iran; 3Department of Pharmaceutical Nanotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran; 4Nanotechnology Research Centre, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran; 5Universal Scientific Education and Research Network (USERN), Tehran, Iran; 6Polymer Research Laboratory, Department of Chemistry, Sharif University of Technology, Tehran 11365-9516, Iran; 7Student Research Committee, Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 8Cellular and Molecular Biology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 9Biomaterial Group, Department of Biomedical Engineering, Amirkabir University of Technology, Tehran, Iran; 10Department of Pharmaceutics and Pharmaceutical Nanotechnology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 11School of Dentistry, Marquette University, Milwaukee, WI 53233, USA; 12Department of Chemical Engineering, Northeastern University, Boston, MA 02115, USACorrespondence: Thomas J Webster; Mohammadreza Tahriri Tel +1 617 373 6585Email th.webster@neu.edu; mohammadreza.tahriri@marquette.eduAbstract: With continual rapid developments in the biomedical field and understanding of the important mechanisms and pharmacokinetics of biological molecules, controlled drug delivery systems (CDDSs) have been at the forefront over conventional drug delivery systems. Over the past several years, scientists have placed boundless energy and time into exploiting a wide variety of excipients, particularly diverse polymers, both natural and synthetic. More recently, the development of nano polymer blends has achieved noteworthy attention due to their amazing properties, such as biocompatibility, biodegradability and more importantly, their pivotal role in controlled and sustained drug release in vitro and in vivo. These compounds come with a number of effective benefits for improving problems of targeted or controlled drug and gene delivery systems; thus, they have been extensively used in medical and pharmaceutical applications. Additionally, they are quite attractive for wound dressings, textiles, tissue engineering, and biomedical prostheses. In this sense, some important and workable natural polymers (namely, chitosan (CS), starch and cellulose) and some applicable synthetic ones (such as poly-lactic-co-glycolic acid (PLGA), poly(lactic acid) (PLA) and poly-glycolic acid (PGA)) have played an indispensable role over the last two decades for their therapeutic effects owing to their appealing and renewable biological properties. According to our data, this is the first review article highlighting CDDSs composed of diverse natural and synthetic nano biopolymers, blended for biological purposes, mostly over the past five years; other reviews have just briefly mentioned the use of such blended polymers. We, additionally, try to make comparisons between various nano blending systems in terms of improved sustained and controlled drug release behavior.Keywords: polymer blends, drug delivery, wound dressing, PLGA, chitosan, starchMaghsoudi STaghavi Shahraki BRabiee NFatahi YDinarvand RTavakolizadeh MAhmadi SRabiee MBagherzadeh MPourjavadi AFarhadnejad HTahriri MWebster TJTayebi LDove Medical Pressarticlepolymer blendsdrug deliverywound dressingplgachitosanstarchMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 15, Pp 4363-4392 (2020)

Burgeoning Polymer Nano Blends for Improved Controlled Drug Release: A Review

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