Exploring reward-related attention selectivity deficits in Parkinson’s disease

Abstract An important aspect of managing a limited cognitive resource like attention is to use the reward value of stimuli to prioritize the allocation of attention to higher-value over lower-value stimuli. Recent evidence suggests this depends on dopaminergic signaling of reward. In Parkinson’s dis...

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Autores principales:	Matthew J. D. Pilgrim, Zhen-Yi Andy Ou, Madeleine Sharp
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/01c6453e06154dcfaf9614c179dc1f52
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spelling	oai:doaj.org-article:01c6453e06154dcfaf9614c179dc1f522021-12-02T17:26:55ZExploring reward-related attention selectivity deficits in Parkinson’s disease10.1038/s41598-021-97526-72045-2322https://doaj.org/article/01c6453e06154dcfaf9614c179dc1f522021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-97526-7https://doaj.org/toc/2045-2322Abstract An important aspect of managing a limited cognitive resource like attention is to use the reward value of stimuli to prioritize the allocation of attention to higher-value over lower-value stimuli. Recent evidence suggests this depends on dopaminergic signaling of reward. In Parkinson’s disease, both reward sensitivity and attention are impaired, but whether these deficits are directly related to one another is unknown. We tested whether Parkinson’s patients use reward information when automatically allocating their attention and whether this is modulated by dopamine replacement. We compared patients, tested both ON and OFF dopamine replacement medication, to older controls using a standard attention capture task. First, participants learned the different reward values of stimuli. Then, these reward-associated stimuli were used as distractors in a visual search task. We found that patients were generally distracted by the presence of the distractors but that the degree of distraction caused by the high-value and low-value distractors was similar. Furthermore, we found no evidence to support the possibility that dopamine replacement modulates the effect of reward on automatic attention allocation. Our results suggest a possible inability in Parkinson’s patients to use the reward value of stimuli when automatically allocating their attention, and raise the possibility that reward-driven allocation of resources may affect the adaptive modulation of other cognitive processes.Matthew J. D. PilgrimZhen-Yi Andy OuMadeleine SharpNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Matthew J. D. Pilgrim Zhen-Yi Andy Ou Madeleine Sharp Exploring reward-related attention selectivity deficits in Parkinson’s disease
description	Abstract An important aspect of managing a limited cognitive resource like attention is to use the reward value of stimuli to prioritize the allocation of attention to higher-value over lower-value stimuli. Recent evidence suggests this depends on dopaminergic signaling of reward. In Parkinson’s disease, both reward sensitivity and attention are impaired, but whether these deficits are directly related to one another is unknown. We tested whether Parkinson’s patients use reward information when automatically allocating their attention and whether this is modulated by dopamine replacement. We compared patients, tested both ON and OFF dopamine replacement medication, to older controls using a standard attention capture task. First, participants learned the different reward values of stimuli. Then, these reward-associated stimuli were used as distractors in a visual search task. We found that patients were generally distracted by the presence of the distractors but that the degree of distraction caused by the high-value and low-value distractors was similar. Furthermore, we found no evidence to support the possibility that dopamine replacement modulates the effect of reward on automatic attention allocation. Our results suggest a possible inability in Parkinson’s patients to use the reward value of stimuli when automatically allocating their attention, and raise the possibility that reward-driven allocation of resources may affect the adaptive modulation of other cognitive processes.
format	article
author	Matthew J. D. Pilgrim Zhen-Yi Andy Ou Madeleine Sharp
author_facet	Matthew J. D. Pilgrim Zhen-Yi Andy Ou Madeleine Sharp
author_sort	Matthew J. D. Pilgrim
title	Exploring reward-related attention selectivity deficits in Parkinson’s disease
title_short	Exploring reward-related attention selectivity deficits in Parkinson’s disease
title_full	Exploring reward-related attention selectivity deficits in Parkinson’s disease
title_fullStr	Exploring reward-related attention selectivity deficits in Parkinson’s disease
title_full_unstemmed	Exploring reward-related attention selectivity deficits in Parkinson’s disease
title_sort	exploring reward-related attention selectivity deficits in parkinson’s disease
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/01c6453e06154dcfaf9614c179dc1f52
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Exploring reward-related attention selectivity deficits in Parkinson’s disease

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