The Potential Role of Cytokine Storm Pathway in the Clinical Course of Viral Respiratory Pandemic
The “cytokine storm” (CS) consists of a spectrum of different immune dysregulation disorders characterized by constitutional symptoms, systemic inflammation and multiorgan dysfunction triggered by an uncontrolled immune response. Particularly in respiratory virus infections, the cytokine storm plays...
Guardado en:
| Autores principales: | , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
MDPI AG
2021
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/01c998c5cb4e4eff83ede8d1e8fe1e62 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:01c998c5cb4e4eff83ede8d1e8fe1e62 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:01c998c5cb4e4eff83ede8d1e8fe1e622021-11-25T16:50:51ZThe Potential Role of Cytokine Storm Pathway in the Clinical Course of Viral Respiratory Pandemic10.3390/biomedicines91116882227-9059https://doaj.org/article/01c998c5cb4e4eff83ede8d1e8fe1e622021-11-01T00:00:00Zhttps://www.mdpi.com/2227-9059/9/11/1688https://doaj.org/toc/2227-9059The “cytokine storm” (CS) consists of a spectrum of different immune dysregulation disorders characterized by constitutional symptoms, systemic inflammation and multiorgan dysfunction triggered by an uncontrolled immune response. Particularly in respiratory virus infections, the cytokine storm plays a primary role in the pathogenesis of respiratory disease and the clinical outcome of respiratory diseases, leading to complications such as alveolar edema and hypoxia. In this review, we wanted to analyze the different pathogenetic mechanisms involved in the various respiratory viral pandemics (COVID-19; SARS; MERS; H1N1 influenza A and Spanish flu) which have affected humans in this and last century, with particular attention to the phenomenon of the “cytokine storm” which determines the clinical severity of the respiratory disease and consequently its lethality.Giuseppe MurdacaFrancesca PaladinAlessandro TonacciStefania IsolaAlessandro AllegraSebastiano GangemiMDPI AGarticleCOVID-19SARSMERSSpanish fluH1N1cytokine stormBiology (General)QH301-705.5ENBiomedicines, Vol 9, Iss 1688, p 1688 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
COVID-19 SARS MERS Spanish flu H1N1 cytokine storm Biology (General) QH301-705.5 |
| spellingShingle |
COVID-19 SARS MERS Spanish flu H1N1 cytokine storm Biology (General) QH301-705.5 Giuseppe Murdaca Francesca Paladin Alessandro Tonacci Stefania Isola Alessandro Allegra Sebastiano Gangemi The Potential Role of Cytokine Storm Pathway in the Clinical Course of Viral Respiratory Pandemic |
| description |
The “cytokine storm” (CS) consists of a spectrum of different immune dysregulation disorders characterized by constitutional symptoms, systemic inflammation and multiorgan dysfunction triggered by an uncontrolled immune response. Particularly in respiratory virus infections, the cytokine storm plays a primary role in the pathogenesis of respiratory disease and the clinical outcome of respiratory diseases, leading to complications such as alveolar edema and hypoxia. In this review, we wanted to analyze the different pathogenetic mechanisms involved in the various respiratory viral pandemics (COVID-19; SARS; MERS; H1N1 influenza A and Spanish flu) which have affected humans in this and last century, with particular attention to the phenomenon of the “cytokine storm” which determines the clinical severity of the respiratory disease and consequently its lethality. |
| format |
article |
| author |
Giuseppe Murdaca Francesca Paladin Alessandro Tonacci Stefania Isola Alessandro Allegra Sebastiano Gangemi |
| author_facet |
Giuseppe Murdaca Francesca Paladin Alessandro Tonacci Stefania Isola Alessandro Allegra Sebastiano Gangemi |
| author_sort |
Giuseppe Murdaca |
| title |
The Potential Role of Cytokine Storm Pathway in the Clinical Course of Viral Respiratory Pandemic |
| title_short |
The Potential Role of Cytokine Storm Pathway in the Clinical Course of Viral Respiratory Pandemic |
| title_full |
The Potential Role of Cytokine Storm Pathway in the Clinical Course of Viral Respiratory Pandemic |
| title_fullStr |
The Potential Role of Cytokine Storm Pathway in the Clinical Course of Viral Respiratory Pandemic |
| title_full_unstemmed |
The Potential Role of Cytokine Storm Pathway in the Clinical Course of Viral Respiratory Pandemic |
| title_sort |
potential role of cytokine storm pathway in the clinical course of viral respiratory pandemic |
| publisher |
MDPI AG |
| publishDate |
2021 |
| url |
https://doaj.org/article/01c998c5cb4e4eff83ede8d1e8fe1e62 |
| work_keys_str_mv |
AT giuseppemurdaca thepotentialroleofcytokinestormpathwayintheclinicalcourseofviralrespiratorypandemic AT francescapaladin thepotentialroleofcytokinestormpathwayintheclinicalcourseofviralrespiratorypandemic AT alessandrotonacci thepotentialroleofcytokinestormpathwayintheclinicalcourseofviralrespiratorypandemic AT stefaniaisola thepotentialroleofcytokinestormpathwayintheclinicalcourseofviralrespiratorypandemic AT alessandroallegra thepotentialroleofcytokinestormpathwayintheclinicalcourseofviralrespiratorypandemic AT sebastianogangemi thepotentialroleofcytokinestormpathwayintheclinicalcourseofviralrespiratorypandemic AT giuseppemurdaca potentialroleofcytokinestormpathwayintheclinicalcourseofviralrespiratorypandemic AT francescapaladin potentialroleofcytokinestormpathwayintheclinicalcourseofviralrespiratorypandemic AT alessandrotonacci potentialroleofcytokinestormpathwayintheclinicalcourseofviralrespiratorypandemic AT stefaniaisola potentialroleofcytokinestormpathwayintheclinicalcourseofviralrespiratorypandemic AT alessandroallegra potentialroleofcytokinestormpathwayintheclinicalcourseofviralrespiratorypandemic AT sebastianogangemi potentialroleofcytokinestormpathwayintheclinicalcourseofviralrespiratorypandemic |
| _version_ |
1718412875613077504 |