Circulating tRNA-derived small RNAs (tsRNAs) signature for the diagnosis and prognosis of breast cancer

Abstract Liquid biopsy is noninvasive and convenient to detect cancer-derived materials in blood or other body fluids. The aim of this study was to identify tRNA-derived small RNAs (tsRNAs) in plasma that could distinguish patients with breast cancer (BC) from healthy controls. Basing on high-throug...

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Autores principales:	Jingyi Wang, Ge Ma, Han Ge, Xu Han, Xinrui Mao, Xinyang Wang, Jordee Selvamanee Veeramootoo, Tiansong Xia, Xiaoan Liu, Shui Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/01cb1c6a0d074869b7a1a9d2adc0a4dd
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spelling	oai:doaj.org-article:01cb1c6a0d074869b7a1a9d2adc0a4dd2021-12-02T15:16:18ZCirculating tRNA-derived small RNAs (tsRNAs) signature for the diagnosis and prognosis of breast cancer10.1038/s41523-020-00211-72374-4677https://doaj.org/article/01cb1c6a0d074869b7a1a9d2adc0a4dd2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41523-020-00211-7https://doaj.org/toc/2374-4677Abstract Liquid biopsy is noninvasive and convenient to detect cancer-derived materials in blood or other body fluids. The aim of this study was to identify tRNA-derived small RNAs (tsRNAs) in plasma that could distinguish patients with breast cancer (BC) from healthy controls. Basing on high-throughput sequencing, 15 significantly upregulated tsRNAs were selected and assessed in cell supernatants and cell lines. 6 tsRNAs were identified and verified in a large cohort of 120 patients with BC and 112 healthy controls. tRF-Arg-CCT-017, tRF-Gly-CCC-001, and tiRNA-Phe-GAA-003 could serve as novel diagnostic biomarkers. Meanwhile, tRF-Arg-CCT-017 and tiRNA-Phe-GAA-003 could also act as prognostic biomarkers. Target genes of these tsRNAs were related to the development of cancers. These results suggested that specific tsRNAs in plasma might serve as diagnostic and prognostic biomarkers of BC.Jingyi WangGe MaHan GeXu HanXinrui MaoXinyang WangJordee Selvamanee VeeramootooTiansong XiaXiaoan LiuShui WangNature PortfolioarticleNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENnpj Breast Cancer, Vol 7, Iss 1, Pp 1-5 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Jingyi Wang Ge Ma Han Ge Xu Han Xinrui Mao Xinyang Wang Jordee Selvamanee Veeramootoo Tiansong Xia Xiaoan Liu Shui Wang Circulating tRNA-derived small RNAs (tsRNAs) signature for the diagnosis and prognosis of breast cancer
description	Abstract Liquid biopsy is noninvasive and convenient to detect cancer-derived materials in blood or other body fluids. The aim of this study was to identify tRNA-derived small RNAs (tsRNAs) in plasma that could distinguish patients with breast cancer (BC) from healthy controls. Basing on high-throughput sequencing, 15 significantly upregulated tsRNAs were selected and assessed in cell supernatants and cell lines. 6 tsRNAs were identified and verified in a large cohort of 120 patients with BC and 112 healthy controls. tRF-Arg-CCT-017, tRF-Gly-CCC-001, and tiRNA-Phe-GAA-003 could serve as novel diagnostic biomarkers. Meanwhile, tRF-Arg-CCT-017 and tiRNA-Phe-GAA-003 could also act as prognostic biomarkers. Target genes of these tsRNAs were related to the development of cancers. These results suggested that specific tsRNAs in plasma might serve as diagnostic and prognostic biomarkers of BC.
format	article
author	Jingyi Wang Ge Ma Han Ge Xu Han Xinrui Mao Xinyang Wang Jordee Selvamanee Veeramootoo Tiansong Xia Xiaoan Liu Shui Wang
author_facet	Jingyi Wang Ge Ma Han Ge Xu Han Xinrui Mao Xinyang Wang Jordee Selvamanee Veeramootoo Tiansong Xia Xiaoan Liu Shui Wang
author_sort	Jingyi Wang
title	Circulating tRNA-derived small RNAs (tsRNAs) signature for the diagnosis and prognosis of breast cancer
title_short	Circulating tRNA-derived small RNAs (tsRNAs) signature for the diagnosis and prognosis of breast cancer
title_full	Circulating tRNA-derived small RNAs (tsRNAs) signature for the diagnosis and prognosis of breast cancer
title_fullStr	Circulating tRNA-derived small RNAs (tsRNAs) signature for the diagnosis and prognosis of breast cancer
title_full_unstemmed	Circulating tRNA-derived small RNAs (tsRNAs) signature for the diagnosis and prognosis of breast cancer
title_sort	circulating trna-derived small rnas (tsrnas) signature for the diagnosis and prognosis of breast cancer
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/01cb1c6a0d074869b7a1a9d2adc0a4dd
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Circulating tRNA-derived small RNAs (tsRNAs) signature for the diagnosis and prognosis of breast cancer

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