Numerical simulation of novel concept 4D cardiac microtomography for small rodents based on all-optical Thomson scattering X-ray sources

Abstract Accurate dynamic three-dimensional (4D) imaging of the heart of small rodents is required for the preclinical study of cardiac biomechanics and their modification under pathological conditions, but technological challenges are met in laboratory practice due to the very small size and high p...

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Autores principales:	Daniele Panetta, Luca Labate, Lucia Billeci, Nicole Di Lascio, Giuseppina Esposito, Francesco Faita, Giovanni Mettivier, Daniele Palla, Luciano Pandola, Pietro Pisciotta, Giorgio Russo, Antonio Sarno, Paolo Tomassini, Piero A. Salvadori, Leonida A. Gizzi, Paolo Russo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/01cfc0593c5c41adbb64e5fc9d0ce370
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spelling	oai:doaj.org-article:01cfc0593c5c41adbb64e5fc9d0ce3702021-12-02T15:08:09ZNumerical simulation of novel concept 4D cardiac microtomography for small rodents based on all-optical Thomson scattering X-ray sources10.1038/s41598-019-44779-y2045-2322https://doaj.org/article/01cfc0593c5c41adbb64e5fc9d0ce3702019-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-019-44779-yhttps://doaj.org/toc/2045-2322Abstract Accurate dynamic three-dimensional (4D) imaging of the heart of small rodents is required for the preclinical study of cardiac biomechanics and their modification under pathological conditions, but technological challenges are met in laboratory practice due to the very small size and high pulse rate of the heart of mice and rats as compared to humans. In 4D X-ray microtomography (4D μCT), the achievable spatio-temporal resolution is hampered by limitations in conventional X-ray sources and detectors. Here, we propose a proof-of-principle 4D μCT platform, exploiting the unique spatial and temporal features of novel concept, all-optical X-ray sources based on Thomson scattering (TS). The main spatial and spectral properties of the photon source are investigated using a TS simulation code. The entire data acquisition workflow has been also simulated, using a novel 4D numerical phantom of a mouse chest with realistic intra- and inter-cycle motion. The image quality of a typical single 3D time frame has been studied using Monte Carlo simulations, taking into account the effects of the typical structure of the TS X-ray beam. Finally, we discuss the perspectives and shortcomings of the proposed platform.Daniele PanettaLuca LabateLucia BilleciNicole Di LascioGiuseppina EspositoFrancesco FaitaGiovanni MettivierDaniele PallaLuciano PandolaPietro PisciottaGiorgio RussoAntonio SarnoPaolo TomassiniPiero A. SalvadoriLeonida A. GizziPaolo RussoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Daniele Panetta Luca Labate Lucia Billeci Nicole Di Lascio Giuseppina Esposito Francesco Faita Giovanni Mettivier Daniele Palla Luciano Pandola Pietro Pisciotta Giorgio Russo Antonio Sarno Paolo Tomassini Piero A. Salvadori Leonida A. Gizzi Paolo Russo Numerical simulation of novel concept 4D cardiac microtomography for small rodents based on all-optical Thomson scattering X-ray sources
description	Abstract Accurate dynamic three-dimensional (4D) imaging of the heart of small rodents is required for the preclinical study of cardiac biomechanics and their modification under pathological conditions, but technological challenges are met in laboratory practice due to the very small size and high pulse rate of the heart of mice and rats as compared to humans. In 4D X-ray microtomography (4D μCT), the achievable spatio-temporal resolution is hampered by limitations in conventional X-ray sources and detectors. Here, we propose a proof-of-principle 4D μCT platform, exploiting the unique spatial and temporal features of novel concept, all-optical X-ray sources based on Thomson scattering (TS). The main spatial and spectral properties of the photon source are investigated using a TS simulation code. The entire data acquisition workflow has been also simulated, using a novel 4D numerical phantom of a mouse chest with realistic intra- and inter-cycle motion. The image quality of a typical single 3D time frame has been studied using Monte Carlo simulations, taking into account the effects of the typical structure of the TS X-ray beam. Finally, we discuss the perspectives and shortcomings of the proposed platform.
format	article
author	Daniele Panetta Luca Labate Lucia Billeci Nicole Di Lascio Giuseppina Esposito Francesco Faita Giovanni Mettivier Daniele Palla Luciano Pandola Pietro Pisciotta Giorgio Russo Antonio Sarno Paolo Tomassini Piero A. Salvadori Leonida A. Gizzi Paolo Russo
author_facet	Daniele Panetta Luca Labate Lucia Billeci Nicole Di Lascio Giuseppina Esposito Francesco Faita Giovanni Mettivier Daniele Palla Luciano Pandola Pietro Pisciotta Giorgio Russo Antonio Sarno Paolo Tomassini Piero A. Salvadori Leonida A. Gizzi Paolo Russo
author_sort	Daniele Panetta
title	Numerical simulation of novel concept 4D cardiac microtomography for small rodents based on all-optical Thomson scattering X-ray sources
title_short	Numerical simulation of novel concept 4D cardiac microtomography for small rodents based on all-optical Thomson scattering X-ray sources
title_full	Numerical simulation of novel concept 4D cardiac microtomography for small rodents based on all-optical Thomson scattering X-ray sources
title_fullStr	Numerical simulation of novel concept 4D cardiac microtomography for small rodents based on all-optical Thomson scattering X-ray sources
title_full_unstemmed	Numerical simulation of novel concept 4D cardiac microtomography for small rodents based on all-optical Thomson scattering X-ray sources
title_sort	numerical simulation of novel concept 4d cardiac microtomography for small rodents based on all-optical thomson scattering x-ray sources
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/01cfc0593c5c41adbb64e5fc9d0ce370
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Numerical simulation of novel concept 4D cardiac microtomography for small rodents based on all-optical Thomson scattering X-ray sources

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