Functional screening implicates miR-371-3p and peroxiredoxin 6 in reversible tolerance to cancer drugs

Acquired resistance significantly limits the efficacy of cancer drug therapies. Here, the authors identify miR-371-3p as a suppressor of drug tolerance in cancer cell lines by its target gene PRDX6, which in turn regulates PLA2/PKCα signalling and ROS levels.

Guardado en:
Detalles Bibliográficos
Autores principales: Nisebita Sahu, Jean-Philippe Stephan, Darlene Dela Cruz, Mark Merchant, Benjamin Haley, Richard Bourgon, Marie Classon, Jeff Settleman
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
Materias:
Q
Acceso en línea:https://doaj.org/article/01cff8d056c9437f9bb6381d87492a43
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
Descripción
Sumario:Acquired resistance significantly limits the efficacy of cancer drug therapies. Here, the authors identify miR-371-3p as a suppressor of drug tolerance in cancer cell lines by its target gene PRDX6, which in turn regulates PLA2/PKCα signalling and ROS levels.