Functional screening implicates miR-371-3p and peroxiredoxin 6 in reversible tolerance to cancer drugs

Acquired resistance significantly limits the efficacy of cancer drug therapies. Here, the authors identify miR-371-3p as a suppressor of drug tolerance in cancer cell lines by its target gene PRDX6, which in turn regulates PLA2/PKCα signalling and ROS levels.

Guardado en:

Detalles Bibliográficos
Autores principales:	Nisebita Sahu, Jean-Philippe Stephan, Darlene Dela Cruz, Mark Merchant, Benjamin Haley, Richard Bourgon, Marie Classon, Jeff Settleman
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/01cff8d056c9437f9bb6381d87492a43
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:01cff8d056c9437f9bb6381d87492a43
record_format	dspace
spelling	oai:doaj.org-article:01cff8d056c9437f9bb6381d87492a432021-12-02T15:34:53ZFunctional screening implicates miR-371-3p and peroxiredoxin 6 in reversible tolerance to cancer drugs10.1038/ncomms123512041-1723https://doaj.org/article/01cff8d056c9437f9bb6381d87492a432016-08-01T00:00:00Zhttps://doi.org/10.1038/ncomms12351https://doaj.org/toc/2041-1723Acquired resistance significantly limits the efficacy of cancer drug therapies. Here, the authors identify miR-371-3p as a suppressor of drug tolerance in cancer cell lines by its target gene PRDX6, which in turn regulates PLA2/PKCα signalling and ROS levels.Nisebita SahuJean-Philippe StephanDarlene Dela CruzMark MerchantBenjamin HaleyRichard BourgonMarie ClassonJeff SettlemanNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nisebita Sahu Jean-Philippe Stephan Darlene Dela Cruz Mark Merchant Benjamin Haley Richard Bourgon Marie Classon Jeff Settleman Functional screening implicates miR-371-3p and peroxiredoxin 6 in reversible tolerance to cancer drugs
description	Acquired resistance significantly limits the efficacy of cancer drug therapies. Here, the authors identify miR-371-3p as a suppressor of drug tolerance in cancer cell lines by its target gene PRDX6, which in turn regulates PLA2/PKCα signalling and ROS levels.
format	article
author	Nisebita Sahu Jean-Philippe Stephan Darlene Dela Cruz Mark Merchant Benjamin Haley Richard Bourgon Marie Classon Jeff Settleman
author_facet	Nisebita Sahu Jean-Philippe Stephan Darlene Dela Cruz Mark Merchant Benjamin Haley Richard Bourgon Marie Classon Jeff Settleman
author_sort	Nisebita Sahu
title	Functional screening implicates miR-371-3p and peroxiredoxin 6 in reversible tolerance to cancer drugs
title_short	Functional screening implicates miR-371-3p and peroxiredoxin 6 in reversible tolerance to cancer drugs
title_full	Functional screening implicates miR-371-3p and peroxiredoxin 6 in reversible tolerance to cancer drugs
title_fullStr	Functional screening implicates miR-371-3p and peroxiredoxin 6 in reversible tolerance to cancer drugs
title_full_unstemmed	Functional screening implicates miR-371-3p and peroxiredoxin 6 in reversible tolerance to cancer drugs
title_sort	functional screening implicates mir-371-3p and peroxiredoxin 6 in reversible tolerance to cancer drugs
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/01cff8d056c9437f9bb6381d87492a43
work_keys_str_mv	AT nisebitasahu functionalscreeningimplicatesmir3713pandperoxiredoxin6inreversibletolerancetocancerdrugs AT jeanphilippestephan functionalscreeningimplicatesmir3713pandperoxiredoxin6inreversibletolerancetocancerdrugs AT darlenedelacruz functionalscreeningimplicatesmir3713pandperoxiredoxin6inreversibletolerancetocancerdrugs AT markmerchant functionalscreeningimplicatesmir3713pandperoxiredoxin6inreversibletolerancetocancerdrugs AT benjaminhaley functionalscreeningimplicatesmir3713pandperoxiredoxin6inreversibletolerancetocancerdrugs AT richardbourgon functionalscreeningimplicatesmir3713pandperoxiredoxin6inreversibletolerancetocancerdrugs AT marieclasson functionalscreeningimplicatesmir3713pandperoxiredoxin6inreversibletolerancetocancerdrugs AT jeffsettleman functionalscreeningimplicatesmir3713pandperoxiredoxin6inreversibletolerancetocancerdrugs
_version_	1718386698089398272

Functional screening implicates miR-371-3p and peroxiredoxin 6 in reversible tolerance to cancer drugs

Ejemplares similares