Persistent elevation of plasma vitamin B12 is strongly associated with solid cancer

Abstract Elevated plasma vitamin B12 has been associated with solid cancers, based on a single B12 measurement. We evaluated the incidence of solid cancers following B12 measurement in patients with persistent elevated B12, compared to patients without elevated B12 and to patients with non-persisten...

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Autores principales: Valentin Lacombe, Floris Chabrun, Carole Lacout, Alaa Ghali, Olivier Capitain, Anne Patsouris, Christian Lavigne, Geoffrey Urbanski
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Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/01d1101b0c214f0ba8f36920854189c8
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spelling oai:doaj.org-article:01d1101b0c214f0ba8f36920854189c82021-12-02T18:02:49ZPersistent elevation of plasma vitamin B12 is strongly associated with solid cancer10.1038/s41598-021-92945-y2045-2322https://doaj.org/article/01d1101b0c214f0ba8f36920854189c82021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-92945-yhttps://doaj.org/toc/2045-2322Abstract Elevated plasma vitamin B12 has been associated with solid cancers, based on a single B12 measurement. We evaluated the incidence of solid cancers following B12 measurement in patients with persistent elevated B12, compared to patients without elevated B12 and to patients with non-persistent elevated B12. The study population included patients with at least two plasma B12 measurements without already known elevated-B12-related causes. Patients with elevated plasma B12 (≥ 1000 ng/L) at first measurement (n = 344) were matched for age and sex with patients having 2 normal B12 measurements (< 1000 ng/L) (NN group, n = 344). The patients with elevated plasma B12 at first measurement were split into 2 groups, according to the presence (EE group, n = 144) or the absence (EN group, n = 200) of persistent elevated plasma B12 at second measurement. We compared the cancer-free survival during 60 months between the groups after adjustment for the other elevated-B12-related causes in a survival competing risk model. Compared to the NN group, a persistent elevated plasma B12 ≥ 1000 ng/mL was strongly associated with the occurrence of solid cancer (HR 5.90 [95% CI 2.79–12.45], p < 0.001), contrary to non-persistent plasma B12 elevation (p = 0.29). These results could help to select patients in whom the screening for solid cancers would be of interest.Valentin LacombeFloris ChabrunCarole LacoutAlaa GhaliOlivier CapitainAnne PatsourisChristian LavigneGeoffrey UrbanskiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Valentin Lacombe
Floris Chabrun
Carole Lacout
Alaa Ghali
Olivier Capitain
Anne Patsouris
Christian Lavigne
Geoffrey Urbanski
Persistent elevation of plasma vitamin B12 is strongly associated with solid cancer
description Abstract Elevated plasma vitamin B12 has been associated with solid cancers, based on a single B12 measurement. We evaluated the incidence of solid cancers following B12 measurement in patients with persistent elevated B12, compared to patients without elevated B12 and to patients with non-persistent elevated B12. The study population included patients with at least two plasma B12 measurements without already known elevated-B12-related causes. Patients with elevated plasma B12 (≥ 1000 ng/L) at first measurement (n = 344) were matched for age and sex with patients having 2 normal B12 measurements (< 1000 ng/L) (NN group, n = 344). The patients with elevated plasma B12 at first measurement were split into 2 groups, according to the presence (EE group, n = 144) or the absence (EN group, n = 200) of persistent elevated plasma B12 at second measurement. We compared the cancer-free survival during 60 months between the groups after adjustment for the other elevated-B12-related causes in a survival competing risk model. Compared to the NN group, a persistent elevated plasma B12 ≥ 1000 ng/mL was strongly associated with the occurrence of solid cancer (HR 5.90 [95% CI 2.79–12.45], p < 0.001), contrary to non-persistent plasma B12 elevation (p = 0.29). These results could help to select patients in whom the screening for solid cancers would be of interest.
format article
author Valentin Lacombe
Floris Chabrun
Carole Lacout
Alaa Ghali
Olivier Capitain
Anne Patsouris
Christian Lavigne
Geoffrey Urbanski
author_facet Valentin Lacombe
Floris Chabrun
Carole Lacout
Alaa Ghali
Olivier Capitain
Anne Patsouris
Christian Lavigne
Geoffrey Urbanski
author_sort Valentin Lacombe
title Persistent elevation of plasma vitamin B12 is strongly associated with solid cancer
title_short Persistent elevation of plasma vitamin B12 is strongly associated with solid cancer
title_full Persistent elevation of plasma vitamin B12 is strongly associated with solid cancer
title_fullStr Persistent elevation of plasma vitamin B12 is strongly associated with solid cancer
title_full_unstemmed Persistent elevation of plasma vitamin B12 is strongly associated with solid cancer
title_sort persistent elevation of plasma vitamin b12 is strongly associated with solid cancer
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/01d1101b0c214f0ba8f36920854189c8
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AT florischabrun persistentelevationofplasmavitaminb12isstronglyassociatedwithsolidcancer
AT carolelacout persistentelevationofplasmavitaminb12isstronglyassociatedwithsolidcancer
AT alaaghali persistentelevationofplasmavitaminb12isstronglyassociatedwithsolidcancer
AT oliviercapitain persistentelevationofplasmavitaminb12isstronglyassociatedwithsolidcancer
AT annepatsouris persistentelevationofplasmavitaminb12isstronglyassociatedwithsolidcancer
AT christianlavigne persistentelevationofplasmavitaminb12isstronglyassociatedwithsolidcancer
AT geoffreyurbanski persistentelevationofplasmavitaminb12isstronglyassociatedwithsolidcancer
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