Persistent elevation of plasma vitamin B12 is strongly associated with solid cancer
Abstract Elevated plasma vitamin B12 has been associated with solid cancers, based on a single B12 measurement. We evaluated the incidence of solid cancers following B12 measurement in patients with persistent elevated B12, compared to patients without elevated B12 and to patients with non-persisten...
Guardado en:
Autores principales: | , , , , , , , |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2021
|
Materias: | |
Acceso en línea: | https://doaj.org/article/01d1101b0c214f0ba8f36920854189c8 |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
id |
oai:doaj.org-article:01d1101b0c214f0ba8f36920854189c8 |
---|---|
record_format |
dspace |
spelling |
oai:doaj.org-article:01d1101b0c214f0ba8f36920854189c82021-12-02T18:02:49ZPersistent elevation of plasma vitamin B12 is strongly associated with solid cancer10.1038/s41598-021-92945-y2045-2322https://doaj.org/article/01d1101b0c214f0ba8f36920854189c82021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-92945-yhttps://doaj.org/toc/2045-2322Abstract Elevated plasma vitamin B12 has been associated with solid cancers, based on a single B12 measurement. We evaluated the incidence of solid cancers following B12 measurement in patients with persistent elevated B12, compared to patients without elevated B12 and to patients with non-persistent elevated B12. The study population included patients with at least two plasma B12 measurements without already known elevated-B12-related causes. Patients with elevated plasma B12 (≥ 1000 ng/L) at first measurement (n = 344) were matched for age and sex with patients having 2 normal B12 measurements (< 1000 ng/L) (NN group, n = 344). The patients with elevated plasma B12 at first measurement were split into 2 groups, according to the presence (EE group, n = 144) or the absence (EN group, n = 200) of persistent elevated plasma B12 at second measurement. We compared the cancer-free survival during 60 months between the groups after adjustment for the other elevated-B12-related causes in a survival competing risk model. Compared to the NN group, a persistent elevated plasma B12 ≥ 1000 ng/mL was strongly associated with the occurrence of solid cancer (HR 5.90 [95% CI 2.79–12.45], p < 0.001), contrary to non-persistent plasma B12 elevation (p = 0.29). These results could help to select patients in whom the screening for solid cancers would be of interest.Valentin LacombeFloris ChabrunCarole LacoutAlaa GhaliOlivier CapitainAnne PatsourisChristian LavigneGeoffrey UrbanskiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021) |
institution |
DOAJ |
collection |
DOAJ |
language |
EN |
topic |
Medicine R Science Q |
spellingShingle |
Medicine R Science Q Valentin Lacombe Floris Chabrun Carole Lacout Alaa Ghali Olivier Capitain Anne Patsouris Christian Lavigne Geoffrey Urbanski Persistent elevation of plasma vitamin B12 is strongly associated with solid cancer |
description |
Abstract Elevated plasma vitamin B12 has been associated with solid cancers, based on a single B12 measurement. We evaluated the incidence of solid cancers following B12 measurement in patients with persistent elevated B12, compared to patients without elevated B12 and to patients with non-persistent elevated B12. The study population included patients with at least two plasma B12 measurements without already known elevated-B12-related causes. Patients with elevated plasma B12 (≥ 1000 ng/L) at first measurement (n = 344) were matched for age and sex with patients having 2 normal B12 measurements (< 1000 ng/L) (NN group, n = 344). The patients with elevated plasma B12 at first measurement were split into 2 groups, according to the presence (EE group, n = 144) or the absence (EN group, n = 200) of persistent elevated plasma B12 at second measurement. We compared the cancer-free survival during 60 months between the groups after adjustment for the other elevated-B12-related causes in a survival competing risk model. Compared to the NN group, a persistent elevated plasma B12 ≥ 1000 ng/mL was strongly associated with the occurrence of solid cancer (HR 5.90 [95% CI 2.79–12.45], p < 0.001), contrary to non-persistent plasma B12 elevation (p = 0.29). These results could help to select patients in whom the screening for solid cancers would be of interest. |
format |
article |
author |
Valentin Lacombe Floris Chabrun Carole Lacout Alaa Ghali Olivier Capitain Anne Patsouris Christian Lavigne Geoffrey Urbanski |
author_facet |
Valentin Lacombe Floris Chabrun Carole Lacout Alaa Ghali Olivier Capitain Anne Patsouris Christian Lavigne Geoffrey Urbanski |
author_sort |
Valentin Lacombe |
title |
Persistent elevation of plasma vitamin B12 is strongly associated with solid cancer |
title_short |
Persistent elevation of plasma vitamin B12 is strongly associated with solid cancer |
title_full |
Persistent elevation of plasma vitamin B12 is strongly associated with solid cancer |
title_fullStr |
Persistent elevation of plasma vitamin B12 is strongly associated with solid cancer |
title_full_unstemmed |
Persistent elevation of plasma vitamin B12 is strongly associated with solid cancer |
title_sort |
persistent elevation of plasma vitamin b12 is strongly associated with solid cancer |
publisher |
Nature Portfolio |
publishDate |
2021 |
url |
https://doaj.org/article/01d1101b0c214f0ba8f36920854189c8 |
work_keys_str_mv |
AT valentinlacombe persistentelevationofplasmavitaminb12isstronglyassociatedwithsolidcancer AT florischabrun persistentelevationofplasmavitaminb12isstronglyassociatedwithsolidcancer AT carolelacout persistentelevationofplasmavitaminb12isstronglyassociatedwithsolidcancer AT alaaghali persistentelevationofplasmavitaminb12isstronglyassociatedwithsolidcancer AT oliviercapitain persistentelevationofplasmavitaminb12isstronglyassociatedwithsolidcancer AT annepatsouris persistentelevationofplasmavitaminb12isstronglyassociatedwithsolidcancer AT christianlavigne persistentelevationofplasmavitaminb12isstronglyassociatedwithsolidcancer AT geoffreyurbanski persistentelevationofplasmavitaminb12isstronglyassociatedwithsolidcancer |
_version_ |
1718378847924125696 |