Recovery in stroke rehabilitation through the rotation of preferred directions induced by bimanual movements: a computational study.

Stroke patients recover more effectively when they are rehabilitated with bimanual movement rather than with unimanual movement; however, it remains unclear why bimanual movement is more effective for stroke recovery. Using a computational model of stroke recovery, this study suggests that bimanual...

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Autores principales:	Ken Takiyama, Masato Okada
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/01d1e35120ef491ba27fa1919d713f37
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spelling	oai:doaj.org-article:01d1e35120ef491ba27fa1919d713f372021-11-18T07:17:32ZRecovery in stroke rehabilitation through the rotation of preferred directions induced by bimanual movements: a computational study.1932-620310.1371/journal.pone.0037594https://doaj.org/article/01d1e35120ef491ba27fa1919d713f372012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22655060/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Stroke patients recover more effectively when they are rehabilitated with bimanual movement rather than with unimanual movement; however, it remains unclear why bimanual movement is more effective for stroke recovery. Using a computational model of stroke recovery, this study suggests that bimanual movement facilitates the reorganization of a damaged motor cortex because this movement induces rotations in the preferred directions (PDs) of motor cortex neurons. Although the tuning curves of these neurons differ during unimanual and bimanual movement, changes in PD, but not changes in modulation depth, facilitate such reorganization. In addition, this reorganization was facilitated only when encoding PDs are rotated, but decoding PDs are not rotated. Bimanual movement facilitates reorganization because this movement changes neural activities through inter-hemispheric inhibition without changing cortical-spinal-muscle connections. Furthermore, stronger inter-hemispheric inhibition between motor cortices results in more effective reorganization. Thus, this study suggests that bimanual movement is effective for stroke rehabilitation because this movement rotates the encoding PDs of motor cortex neurons.Ken TakiyamaMasato OkadaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 5, p e37594 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ken Takiyama Masato Okada Recovery in stroke rehabilitation through the rotation of preferred directions induced by bimanual movements: a computational study.
description	Stroke patients recover more effectively when they are rehabilitated with bimanual movement rather than with unimanual movement; however, it remains unclear why bimanual movement is more effective for stroke recovery. Using a computational model of stroke recovery, this study suggests that bimanual movement facilitates the reorganization of a damaged motor cortex because this movement induces rotations in the preferred directions (PDs) of motor cortex neurons. Although the tuning curves of these neurons differ during unimanual and bimanual movement, changes in PD, but not changes in modulation depth, facilitate such reorganization. In addition, this reorganization was facilitated only when encoding PDs are rotated, but decoding PDs are not rotated. Bimanual movement facilitates reorganization because this movement changes neural activities through inter-hemispheric inhibition without changing cortical-spinal-muscle connections. Furthermore, stronger inter-hemispheric inhibition between motor cortices results in more effective reorganization. Thus, this study suggests that bimanual movement is effective for stroke rehabilitation because this movement rotates the encoding PDs of motor cortex neurons.
format	article
author	Ken Takiyama Masato Okada
author_facet	Ken Takiyama Masato Okada
author_sort	Ken Takiyama
title	Recovery in stroke rehabilitation through the rotation of preferred directions induced by bimanual movements: a computational study.
title_short	Recovery in stroke rehabilitation through the rotation of preferred directions induced by bimanual movements: a computational study.
title_full	Recovery in stroke rehabilitation through the rotation of preferred directions induced by bimanual movements: a computational study.
title_fullStr	Recovery in stroke rehabilitation through the rotation of preferred directions induced by bimanual movements: a computational study.
title_full_unstemmed	Recovery in stroke rehabilitation through the rotation of preferred directions induced by bimanual movements: a computational study.
title_sort	recovery in stroke rehabilitation through the rotation of preferred directions induced by bimanual movements: a computational study.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/01d1e35120ef491ba27fa1919d713f37
work_keys_str_mv	AT kentakiyama recoveryinstrokerehabilitationthroughtherotationofpreferreddirectionsinducedbybimanualmovementsacomputationalstudy AT masatookada recoveryinstrokerehabilitationthroughtherotationofpreferreddirectionsinducedbybimanualmovementsacomputationalstudy
_version_	1718423640665489408

Recovery in stroke rehabilitation through the rotation of preferred directions induced by bimanual movements: a computational study.

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