SIRT7 is a histone desuccinylase that functionally links to chromatin compaction and genome stability

SIRT7 is a member of sirtuin family proteins that are described as NAD+-dependent class III histone deacetylases. Here, the authors show that SIRT7 is histone desuccinylase catalysing H3K122 desuccinylation, thereby promoting chromatin condensation and repair of DNA double strand breaks.

Guardado en:

Detalles Bibliográficos
Autores principales:	Lei Li, Lan Shi, Shangda Yang, Ruorong Yan, Di Zhang, Jianguo Yang, Lin He, Wanjin Li, Xia Yi, Luyang Sun, Jing Liang, Zhongyi Cheng, Lei Shi, Yongfeng Shang, Wenhua Yu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/01d2d2142bd449bf920ece34e4a0cc1c
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:01d2d2142bd449bf920ece34e4a0cc1c
record_format	dspace
spelling	oai:doaj.org-article:01d2d2142bd449bf920ece34e4a0cc1c2021-12-02T17:32:51ZSIRT7 is a histone desuccinylase that functionally links to chromatin compaction and genome stability10.1038/ncomms122352041-1723https://doaj.org/article/01d2d2142bd449bf920ece34e4a0cc1c2016-07-01T00:00:00Zhttps://doi.org/10.1038/ncomms12235https://doaj.org/toc/2041-1723SIRT7 is a member of sirtuin family proteins that are described as NAD+-dependent class III histone deacetylases. Here, the authors show that SIRT7 is histone desuccinylase catalysing H3K122 desuccinylation, thereby promoting chromatin condensation and repair of DNA double strand breaks.Lei LiLan ShiShangda YangRuorong YanDi ZhangJianguo YangLin HeWanjin LiXia YiLuyang SunJing LiangZhongyi ChengLei ShiYongfeng ShangWenhua YuNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-17 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lei Li Lan Shi Shangda Yang Ruorong Yan Di Zhang Jianguo Yang Lin He Wanjin Li Xia Yi Luyang Sun Jing Liang Zhongyi Cheng Lei Shi Yongfeng Shang Wenhua Yu SIRT7 is a histone desuccinylase that functionally links to chromatin compaction and genome stability
description	SIRT7 is a member of sirtuin family proteins that are described as NAD+-dependent class III histone deacetylases. Here, the authors show that SIRT7 is histone desuccinylase catalysing H3K122 desuccinylation, thereby promoting chromatin condensation and repair of DNA double strand breaks.
format	article
author	Lei Li Lan Shi Shangda Yang Ruorong Yan Di Zhang Jianguo Yang Lin He Wanjin Li Xia Yi Luyang Sun Jing Liang Zhongyi Cheng Lei Shi Yongfeng Shang Wenhua Yu
author_facet	Lei Li Lan Shi Shangda Yang Ruorong Yan Di Zhang Jianguo Yang Lin He Wanjin Li Xia Yi Luyang Sun Jing Liang Zhongyi Cheng Lei Shi Yongfeng Shang Wenhua Yu
author_sort	Lei Li
title	SIRT7 is a histone desuccinylase that functionally links to chromatin compaction and genome stability
title_short	SIRT7 is a histone desuccinylase that functionally links to chromatin compaction and genome stability
title_full	SIRT7 is a histone desuccinylase that functionally links to chromatin compaction and genome stability
title_fullStr	SIRT7 is a histone desuccinylase that functionally links to chromatin compaction and genome stability
title_full_unstemmed	SIRT7 is a histone desuccinylase that functionally links to chromatin compaction and genome stability
title_sort	sirt7 is a histone desuccinylase that functionally links to chromatin compaction and genome stability
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/01d2d2142bd449bf920ece34e4a0cc1c
work_keys_str_mv	AT leili sirt7isahistonedesuccinylasethatfunctionallylinkstochromatincompactionandgenomestability AT lanshi sirt7isahistonedesuccinylasethatfunctionallylinkstochromatincompactionandgenomestability AT shangdayang sirt7isahistonedesuccinylasethatfunctionallylinkstochromatincompactionandgenomestability AT ruorongyan sirt7isahistonedesuccinylasethatfunctionallylinkstochromatincompactionandgenomestability AT dizhang sirt7isahistonedesuccinylasethatfunctionallylinkstochromatincompactionandgenomestability AT jianguoyang sirt7isahistonedesuccinylasethatfunctionallylinkstochromatincompactionandgenomestability AT linhe sirt7isahistonedesuccinylasethatfunctionallylinkstochromatincompactionandgenomestability AT wanjinli sirt7isahistonedesuccinylasethatfunctionallylinkstochromatincompactionandgenomestability AT xiayi sirt7isahistonedesuccinylasethatfunctionallylinkstochromatincompactionandgenomestability AT luyangsun sirt7isahistonedesuccinylasethatfunctionallylinkstochromatincompactionandgenomestability AT jingliang sirt7isahistonedesuccinylasethatfunctionallylinkstochromatincompactionandgenomestability AT zhongyicheng sirt7isahistonedesuccinylasethatfunctionallylinkstochromatincompactionandgenomestability AT leishi sirt7isahistonedesuccinylasethatfunctionallylinkstochromatincompactionandgenomestability AT yongfengshang sirt7isahistonedesuccinylasethatfunctionallylinkstochromatincompactionandgenomestability AT wenhuayu sirt7isahistonedesuccinylasethatfunctionallylinkstochromatincompactionandgenomestability
_version_	1718380163898540032

SIRT7 is a histone desuccinylase that functionally links to chromatin compaction and genome stability

Ejemplares similares