Cerebrospinal fluid oligoclonal immunoglobulin gamma bands and long-term disability progression in multiple sclerosis: a retrospective cohort study

Abstract Multiple sclerosis (MS) patients with immunoglobulin gamma (IgG) oligoclonal bands (OCB) in the cerebrospinal fluid (CSF) have different genetic backgrounds and brain MRI features compared to those without. In this study, we aimed to determine whether CSF-OCB status is associated with long-...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Virginija Danylaité Karrenbauer, Sahl Khalid Bedri, Jan Hillert, Ali Manouchehrinia
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/01d6be95c1a141ee8ecd58413c1b49a1
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:01d6be95c1a141ee8ecd58413c1b49a1
record_format	dspace
spelling	oai:doaj.org-article:01d6be95c1a141ee8ecd58413c1b49a12021-12-02T16:26:30ZCerebrospinal fluid oligoclonal immunoglobulin gamma bands and long-term disability progression in multiple sclerosis: a retrospective cohort study10.1038/s41598-021-94423-x2045-2322https://doaj.org/article/01d6be95c1a141ee8ecd58413c1b49a12021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-94423-xhttps://doaj.org/toc/2045-2322Abstract Multiple sclerosis (MS) patients with immunoglobulin gamma (IgG) oligoclonal bands (OCB) in the cerebrospinal fluid (CSF) have different genetic backgrounds and brain MRI features compared to those without. In this study, we aimed to determine whether CSF-OCB status is associated with long-term disability outcomes. We used Swedish MS register data on clinically definite MS patients with known OCB status. Date of birth, age at MS onset, and time to sustained Expanded Disability Status Scale (EDSS) milestones 3, 4, and 6; time to conversion to secondary progressive (SP) MS, sex, and immunomodulatory treatment (IMTs) duration were collected. Multivariate Cox regression models were used to investigate the association between OCB status and risk of reaching each milestone. The OCB-positive group reached disability milestones at an earlier time and younger age. OCB-positivity significantly increased the risk of reaching EDSS 3.0 (HR = 1.29, 95% CI 1.12 to 1.48, P < 0.001) and 4.0 (HR = 1.38, 95% CI 1.17 to 1.63, P < 0.001). The OCB-positive group had a 20% higher risk of conversion to SPMS. CSF-OCB presence is associated with higher risk of reaching EDSS milestones and conversion to SPMS. Our findings suggest higher disease modifying effect of OCB presence in the early inflammatory stages of MS.Virginija Danylaité KarrenbauerSahl Khalid BedriJan HillertAli ManouchehriniaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Virginija Danylaité Karrenbauer Sahl Khalid Bedri Jan Hillert Ali Manouchehrinia Cerebrospinal fluid oligoclonal immunoglobulin gamma bands and long-term disability progression in multiple sclerosis: a retrospective cohort study
description	Abstract Multiple sclerosis (MS) patients with immunoglobulin gamma (IgG) oligoclonal bands (OCB) in the cerebrospinal fluid (CSF) have different genetic backgrounds and brain MRI features compared to those without. In this study, we aimed to determine whether CSF-OCB status is associated with long-term disability outcomes. We used Swedish MS register data on clinically definite MS patients with known OCB status. Date of birth, age at MS onset, and time to sustained Expanded Disability Status Scale (EDSS) milestones 3, 4, and 6; time to conversion to secondary progressive (SP) MS, sex, and immunomodulatory treatment (IMTs) duration were collected. Multivariate Cox regression models were used to investigate the association between OCB status and risk of reaching each milestone. The OCB-positive group reached disability milestones at an earlier time and younger age. OCB-positivity significantly increased the risk of reaching EDSS 3.0 (HR = 1.29, 95% CI 1.12 to 1.48, P < 0.001) and 4.0 (HR = 1.38, 95% CI 1.17 to 1.63, P < 0.001). The OCB-positive group had a 20% higher risk of conversion to SPMS. CSF-OCB presence is associated with higher risk of reaching EDSS milestones and conversion to SPMS. Our findings suggest higher disease modifying effect of OCB presence in the early inflammatory stages of MS.
format	article
author	Virginija Danylaité Karrenbauer Sahl Khalid Bedri Jan Hillert Ali Manouchehrinia
author_facet	Virginija Danylaité Karrenbauer Sahl Khalid Bedri Jan Hillert Ali Manouchehrinia
author_sort	Virginija Danylaité Karrenbauer
title	Cerebrospinal fluid oligoclonal immunoglobulin gamma bands and long-term disability progression in multiple sclerosis: a retrospective cohort study
title_short	Cerebrospinal fluid oligoclonal immunoglobulin gamma bands and long-term disability progression in multiple sclerosis: a retrospective cohort study
title_full	Cerebrospinal fluid oligoclonal immunoglobulin gamma bands and long-term disability progression in multiple sclerosis: a retrospective cohort study
title_fullStr	Cerebrospinal fluid oligoclonal immunoglobulin gamma bands and long-term disability progression in multiple sclerosis: a retrospective cohort study
title_full_unstemmed	Cerebrospinal fluid oligoclonal immunoglobulin gamma bands and long-term disability progression in multiple sclerosis: a retrospective cohort study
title_sort	cerebrospinal fluid oligoclonal immunoglobulin gamma bands and long-term disability progression in multiple sclerosis: a retrospective cohort study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/01d6be95c1a141ee8ecd58413c1b49a1
work_keys_str_mv	AT virginijadanylaitekarrenbauer cerebrospinalfluidoligoclonalimmunoglobulingammabandsandlongtermdisabilityprogressioninmultiplesclerosisaretrospectivecohortstudy AT sahlkhalidbedri cerebrospinalfluidoligoclonalimmunoglobulingammabandsandlongtermdisabilityprogressioninmultiplesclerosisaretrospectivecohortstudy AT janhillert cerebrospinalfluidoligoclonalimmunoglobulingammabandsandlongtermdisabilityprogressioninmultiplesclerosisaretrospectivecohortstudy AT alimanouchehrinia cerebrospinalfluidoligoclonalimmunoglobulingammabandsandlongtermdisabilityprogressioninmultiplesclerosisaretrospectivecohortstudy
_version_	1718384031902466048

Cerebrospinal fluid oligoclonal immunoglobulin gamma bands and long-term disability progression in multiple sclerosis: a retrospective cohort study

Ejemplares similares