Assessing the effect of weight and weight loss in obese persons with type 2 diabetes

Bradley Curtis1, Risa P Hayes1, Sheri Fehnel2, Laurie Zografos21Global Health Outcomes, Eli Lilly and Co, Indianapolis, IN, USA; 2RTI Health Solutions, Research Triangle Park, NC, USAAbstract: The objective of this study was to assess specific areas of life in which obesity affects individuals with...

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Autores principales:	Bradley Curtis, Risa P Hayes, Sheri Fehnel, Laurie Zografos
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2008
Materias:	Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/01d7a61087f5475a980c85f970c99710
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spelling	oai:doaj.org-article:01d7a61087f5475a980c85f970c997102021-12-02T01:16:18ZAssessing the effect of weight and weight loss in obese persons with type 2 diabetes1178-7007https://doaj.org/article/01d7a61087f5475a980c85f970c997102008-10-01T00:00:00Zhttp://www.dovepress.com/assessing-the-effect-of-weight-and-weight-loss-in-obese-persons-with-t-a2477https://doaj.org/toc/1178-7007Bradley Curtis1, Risa P Hayes1, Sheri Fehnel2, Laurie Zografos21Global Health Outcomes, Eli Lilly and Co, Indianapolis, IN, USA; 2RTI Health Solutions, Research Triangle Park, NC, USAAbstract: The objective of this study was to assess specific areas of life in which obesity affects individuals with type 2 diabetes mellitus (T2DM), and changes that obese persons with T2DM experience with weight loss of varying degrees. Thirty in-depth interviews were conducted in persons identified as: age &ge;40 years, diagnosed with T2DM for &ge;2 years, on oral antihyperglycemic medications &gt;3 months, BMI 30&ndash;35 kg/m2, having attempted to lose weight in the last 2 years. Participants (60% female, mean age 53 years, 53% Caucasian, mean BMI 32.2 kg/m2) agreed that 5% weight loss, while not reflective of an ultimate goal, would be meaningful and important; benefits were expected to accrue in physical functioning, self-confidence, blood glucose levels, and motivation to keep losing weight. Participants reported the greatest effect of weight loss on energy, physical activity, mobility, pain, and clothes/appearance. Participants reported weight affecting mood, with feelings of depression and frustration most commonly described. This research indicates that weight loss is likely to affect health-related quality of life in obese individuals with T2DM. Given the purported weight loss benefits of many emerging diabetic medications, it will be important to include measures of weight-related quality of life in future clinical trials of these agents.Keywords: health-related quality of life, obesity, type 2 diabetes, weight loss, patient-reported outcomes Bradley CurtisRisa P HayesSheri FehnelLaurie ZografosDove Medical PressarticleSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol 2008, Iss default, Pp 13-23 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Specialties of internal medicine RC581-951
spellingShingle	Specialties of internal medicine RC581-951 Bradley Curtis Risa P Hayes Sheri Fehnel Laurie Zografos Assessing the effect of weight and weight loss in obese persons with type 2 diabetes
description	Bradley Curtis1, Risa P Hayes1, Sheri Fehnel2, Laurie Zografos21Global Health Outcomes, Eli Lilly and Co, Indianapolis, IN, USA; 2RTI Health Solutions, Research Triangle Park, NC, USAAbstract: The objective of this study was to assess specific areas of life in which obesity affects individuals with type 2 diabetes mellitus (T2DM), and changes that obese persons with T2DM experience with weight loss of varying degrees. Thirty in-depth interviews were conducted in persons identified as: age &ge;40 years, diagnosed with T2DM for &ge;2 years, on oral antihyperglycemic medications &gt;3 months, BMI 30&ndash;35 kg/m2, having attempted to lose weight in the last 2 years. Participants (60% female, mean age 53 years, 53% Caucasian, mean BMI 32.2 kg/m2) agreed that 5% weight loss, while not reflective of an ultimate goal, would be meaningful and important; benefits were expected to accrue in physical functioning, self-confidence, blood glucose levels, and motivation to keep losing weight. Participants reported the greatest effect of weight loss on energy, physical activity, mobility, pain, and clothes/appearance. Participants reported weight affecting mood, with feelings of depression and frustration most commonly described. This research indicates that weight loss is likely to affect health-related quality of life in obese individuals with T2DM. Given the purported weight loss benefits of many emerging diabetic medications, it will be important to include measures of weight-related quality of life in future clinical trials of these agents.Keywords: health-related quality of life, obesity, type 2 diabetes, weight loss, patient-reported outcomes
format	article
author	Bradley Curtis Risa P Hayes Sheri Fehnel Laurie Zografos
author_facet	Bradley Curtis Risa P Hayes Sheri Fehnel Laurie Zografos
author_sort	Bradley Curtis
title	Assessing the effect of weight and weight loss in obese persons with type 2 diabetes
title_short	Assessing the effect of weight and weight loss in obese persons with type 2 diabetes
title_full	Assessing the effect of weight and weight loss in obese persons with type 2 diabetes
title_fullStr	Assessing the effect of weight and weight loss in obese persons with type 2 diabetes
title_full_unstemmed	Assessing the effect of weight and weight loss in obese persons with type 2 diabetes
title_sort	assessing the effect of weight and weight loss in obese persons with type 2 diabetes
publisher	Dove Medical Press
publishDate	2008
url	https://doaj.org/article/01d7a61087f5475a980c85f970c99710
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Assessing the effect of weight and weight loss in obese persons with type 2 diabetes

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