Pulmonary fibrosis distal airway epithelia are dynamically and structurally dysfunctional

Environmental and genetic risk factors affect the distal airway epithelium in idiopatic pulmonary fibrosis (IPF) but the role of the epithelium in IPF remains unclear. Here the authors show that pathologic activation of the ERBB-YAP axis induces dynamic and structural dysfunction in the distal airwa...

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Autores principales:	Ian T. Stancil, Jacob E. Michalski, Duncan Davis-Hall, Hong Wei Chu, Jin-Ah Park, Chelsea M. Magin, Ivana V. Yang, Bradford J. Smith, Evgenia Dobrinskikh, David A. Schwartz
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/01dae7f647b5461cb308f23c36fac345
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spelling	oai:doaj.org-article:01dae7f647b5461cb308f23c36fac3452021-12-02T16:24:23ZPulmonary fibrosis distal airway epithelia are dynamically and structurally dysfunctional10.1038/s41467-021-24853-82041-1723https://doaj.org/article/01dae7f647b5461cb308f23c36fac3452021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24853-8https://doaj.org/toc/2041-1723Environmental and genetic risk factors affect the distal airway epithelium in idiopatic pulmonary fibrosis (IPF) but the role of the epithelium in IPF remains unclear. Here the authors show that pathologic activation of the ERBB-YAP axis induces dynamic and structural dysfunction in the distal airway epithelium eliciting a pro-fibrotic phenotype in mesenchymal cells.Ian T. StancilJacob E. MichalskiDuncan Davis-HallHong Wei ChuJin-Ah ParkChelsea M. MaginIvana V. YangBradford J. SmithEvgenia DobrinskikhDavid A. SchwartzNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ian T. Stancil Jacob E. Michalski Duncan Davis-Hall Hong Wei Chu Jin-Ah Park Chelsea M. Magin Ivana V. Yang Bradford J. Smith Evgenia Dobrinskikh David A. Schwartz Pulmonary fibrosis distal airway epithelia are dynamically and structurally dysfunctional
description	Environmental and genetic risk factors affect the distal airway epithelium in idiopatic pulmonary fibrosis (IPF) but the role of the epithelium in IPF remains unclear. Here the authors show that pathologic activation of the ERBB-YAP axis induces dynamic and structural dysfunction in the distal airway epithelium eliciting a pro-fibrotic phenotype in mesenchymal cells.
format	article
author	Ian T. Stancil Jacob E. Michalski Duncan Davis-Hall Hong Wei Chu Jin-Ah Park Chelsea M. Magin Ivana V. Yang Bradford J. Smith Evgenia Dobrinskikh David A. Schwartz
author_facet	Ian T. Stancil Jacob E. Michalski Duncan Davis-Hall Hong Wei Chu Jin-Ah Park Chelsea M. Magin Ivana V. Yang Bradford J. Smith Evgenia Dobrinskikh David A. Schwartz
author_sort	Ian T. Stancil
title	Pulmonary fibrosis distal airway epithelia are dynamically and structurally dysfunctional
title_short	Pulmonary fibrosis distal airway epithelia are dynamically and structurally dysfunctional
title_full	Pulmonary fibrosis distal airway epithelia are dynamically and structurally dysfunctional
title_fullStr	Pulmonary fibrosis distal airway epithelia are dynamically and structurally dysfunctional
title_full_unstemmed	Pulmonary fibrosis distal airway epithelia are dynamically and structurally dysfunctional
title_sort	pulmonary fibrosis distal airway epithelia are dynamically and structurally dysfunctional
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/01dae7f647b5461cb308f23c36fac345
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Pulmonary fibrosis distal airway epithelia are dynamically and structurally dysfunctional

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