Degree of differentiation of cutaneous squamous cell carcinoma: a comparison between a Swedish cohort of organ transplant recipients and immunocompetent patients

Background: Organ transplant recipients (OTRs) have a very high risk of developing cutaneous squamous cell carcinoma (cSCC). Immunosuppressed OTRs may have a higher proportion of poorly differentiated cSCC than non-OTRs. Objectives: The aim of this study was to investigate the degree of differen...

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Autores principales:	Caroline Stenman, Helena Gonzalez, Martin Gillstedt, Göran Dellgren, Bengt Hasséus, Erik Holmberg, Helena Rexius, Jenny Öhman, John Paoli
Formato:	article
Lenguaje:	EN
Publicado:	Mattioli1885 2018
Materias:	cutaneous squamous cell carcinoma organ transplant recipients immunosuppression histopathological differentiation nonmelanoma skin cancer Dermatology RL1-803
Acceso en línea:	https://doaj.org/article/01de49134e934bae83d8154b6503c7ba
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spelling	oai:doaj.org-article:01de49134e934bae83d8154b6503c7ba2021-11-17T08:29:57ZDegree of differentiation of cutaneous squamous cell carcinoma: a comparison between a Swedish cohort of organ transplant recipients and immunocompetent patients10.5826/dpc.0804a182160-9381https://doaj.org/article/01de49134e934bae83d8154b6503c7ba2018-10-01T00:00:00Zhttp://dpcj.org/index.php/dpc/article/view/485https://doaj.org/toc/2160-9381 Background: Organ transplant recipients (OTRs) have a very high risk of developing cutaneous squamous cell carcinoma (cSCC). Immunosuppressed OTRs may have a higher proportion of poorly differentiated cSCC than non-OTRs. Objectives: The aim of this study was to investigate the degree of differentiation of cSCCs in OTRs compared with immunocompetent individuals. Patients/Methods: Data from the Swedish Cancer Registry were crosschecked with data from the Transplant registry of the Transplant Institute at Sahlgrenska University Hospital in Gothenburg, Sweden. All OTRs with a diagnosis of cSCC, basosquamous carcinoma, and/or cSCC in situ established at the Department of Dermatology, Sahlgrenska University Hospital, during 2002-2015 were included. The control group consisted of non-OTRs with the same diagnoses during the same time period. Results: During 2002-2015, 82 OTRs diagnosed with 515 tumors and 883 non-OTRs with 1,247 tumors were included. OTRs developed 0.47 tumors/year vs 0.10 tumors/year for non-OTRs, but no significant differences were observed in the degree of tumor differentiation of invasive cSCCs between OTRs and non-OTRs (P = 0.4). The distribution of poorly, moderately, and well-differentiated invasive cSCCs among OTRs and non-OTRs were 8.5% vs 12.5%, 22.1% vs 29.9%, and 69.4% vs 57.6%, respectively. Conclusions: OTRs do not develop a higher proportion of poorly differentiated cSCCs than non-OTRs. Caroline StenmanHelena GonzalezMartin GillstedtGöran DellgrenBengt HasséusErik HolmbergHelena RexiusJenny ÖhmanJohn PaoliMattioli1885articlecutaneous squamous cell carcinomaorgan transplant recipientsimmunosuppressionhistopathological differentiationnonmelanoma skin cancerDermatologyRL1-803ENDermatology Practical & Conceptual, Vol 8, Iss 4 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	cutaneous squamous cell carcinoma organ transplant recipients immunosuppression histopathological differentiation nonmelanoma skin cancer Dermatology RL1-803
spellingShingle	cutaneous squamous cell carcinoma organ transplant recipients immunosuppression histopathological differentiation nonmelanoma skin cancer Dermatology RL1-803 Caroline Stenman Helena Gonzalez Martin Gillstedt Göran Dellgren Bengt Hasséus Erik Holmberg Helena Rexius Jenny Öhman John Paoli Degree of differentiation of cutaneous squamous cell carcinoma: a comparison between a Swedish cohort of organ transplant recipients and immunocompetent patients
description	Background: Organ transplant recipients (OTRs) have a very high risk of developing cutaneous squamous cell carcinoma (cSCC). Immunosuppressed OTRs may have a higher proportion of poorly differentiated cSCC than non-OTRs. Objectives: The aim of this study was to investigate the degree of differentiation of cSCCs in OTRs compared with immunocompetent individuals. Patients/Methods: Data from the Swedish Cancer Registry were crosschecked with data from the Transplant registry of the Transplant Institute at Sahlgrenska University Hospital in Gothenburg, Sweden. All OTRs with a diagnosis of cSCC, basosquamous carcinoma, and/or cSCC in situ established at the Department of Dermatology, Sahlgrenska University Hospital, during 2002-2015 were included. The control group consisted of non-OTRs with the same diagnoses during the same time period. Results: During 2002-2015, 82 OTRs diagnosed with 515 tumors and 883 non-OTRs with 1,247 tumors were included. OTRs developed 0.47 tumors/year vs 0.10 tumors/year for non-OTRs, but no significant differences were observed in the degree of tumor differentiation of invasive cSCCs between OTRs and non-OTRs (P = 0.4). The distribution of poorly, moderately, and well-differentiated invasive cSCCs among OTRs and non-OTRs were 8.5% vs 12.5%, 22.1% vs 29.9%, and 69.4% vs 57.6%, respectively. Conclusions: OTRs do not develop a higher proportion of poorly differentiated cSCCs than non-OTRs.
format	article
author	Caroline Stenman Helena Gonzalez Martin Gillstedt Göran Dellgren Bengt Hasséus Erik Holmberg Helena Rexius Jenny Öhman John Paoli
author_facet	Caroline Stenman Helena Gonzalez Martin Gillstedt Göran Dellgren Bengt Hasséus Erik Holmberg Helena Rexius Jenny Öhman John Paoli
author_sort	Caroline Stenman
title	Degree of differentiation of cutaneous squamous cell carcinoma: a comparison between a Swedish cohort of organ transplant recipients and immunocompetent patients
title_short	Degree of differentiation of cutaneous squamous cell carcinoma: a comparison between a Swedish cohort of organ transplant recipients and immunocompetent patients
title_full	Degree of differentiation of cutaneous squamous cell carcinoma: a comparison between a Swedish cohort of organ transplant recipients and immunocompetent patients
title_fullStr	Degree of differentiation of cutaneous squamous cell carcinoma: a comparison between a Swedish cohort of organ transplant recipients and immunocompetent patients
title_full_unstemmed	Degree of differentiation of cutaneous squamous cell carcinoma: a comparison between a Swedish cohort of organ transplant recipients and immunocompetent patients
title_sort	degree of differentiation of cutaneous squamous cell carcinoma: a comparison between a swedish cohort of organ transplant recipients and immunocompetent patients
publisher	Mattioli1885
publishDate	2018
url	https://doaj.org/article/01de49134e934bae83d8154b6503c7ba
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Degree of differentiation of cutaneous squamous cell carcinoma: a comparison between a Swedish cohort of organ transplant recipients and immunocompetent patients

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