Treatment of human papillomavirus infection in HIV-infected patients

The first reports about HIV (human immunodeficiency virus) were appeared to the 1980s. By 2017 more than 37 million people were living with HIV. Human papilloma virus (HPV) is universally spread, with some estimates showing that about 1% of the sexually active population having genital warts. Human...

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Autores principales:	V. S. Smirnov, T. A. Kudryavtseva
Formato:	article
Lenguaje:	RU
Publicado:	Sankt-Peterburg : NIIÈM imeni Pastera 2021
Materias:	hiv infection human papillomavirus (hpv) hpv clinical manifestations treatment methods imiquimod aldara vartocid immunomodulation therapy Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/01e46969b978452c853cbace7062fc58
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spelling	oai:doaj.org-article:01e46969b978452c853cbace7062fc582021-11-22T07:09:55ZTreatment of human papillomavirus infection in HIV-infected patients2220-76192313-739810.15789/2220-7619-TOH-1233https://doaj.org/article/01e46969b978452c853cbace7062fc582021-02-01T00:00:00Zhttps://www.iimmun.ru/iimm/article/view/1233https://doaj.org/toc/2220-7619https://doaj.org/toc/2313-7398The first reports about HIV (human immunodeficiency virus) were appeared to the 1980s. By 2017 more than 37 million people were living with HIV. Human papilloma virus (HPV) is universally spread, with some estimates showing that about 1% of the sexually active population having genital warts. Human papilloma virus (HPV)-induced infection frequently accompanies the clinical course of HIV and can manifest itself in a full spectrum of clinical-pathologic forms ranging from common warts to malignant neoplasia. Due to the widespread use of antiretroviral therapy, the number of patients with a combined infection (HIV+HPV) is steadily increasing. Here we review current clinical treatment options for HPV manifestations. High-dose antiretroviral therapy does not impede HPV treatment, and can even improve its efficacy in some cases. The topical administration of imiquimod, an immune response modifier, is an effective conservative treatment in HIV-infected patients with HPV. The immunomodulation therapy of imiquimod can serve as an effective alternative of aggressive chemical and mechanical procedures. Maximum efficacy with the lowest replaces rates may be expected from combined use of mechanical ablation methods with a subsequent follow up treatment with imiqui-mod. The best therapeutic result is expected in HIV-positive patients who are received high-dose antiretroviral treatment. The advantages of Vartocid, the modified Russian equivalent of the generic imiquimod.V. S. SmirnovT. A. KudryavtsevaSankt-Peterburg : NIIÈM imeni Pasteraarticlehiv infectionhuman papillomavirus (hpv)hpv clinical manifestationstreatment methodsimiquimodaldaravartocidimmunomodulation therapyInfectious and parasitic diseasesRC109-216RUInfekciâ i Immunitet, Vol 11, Iss 1, Pp 79-84 (2021)
institution	DOAJ
collection	DOAJ
language	RU
topic	hiv infection human papillomavirus (hpv) hpv clinical manifestations treatment methods imiquimod aldara vartocid immunomodulation therapy Infectious and parasitic diseases RC109-216
spellingShingle	hiv infection human papillomavirus (hpv) hpv clinical manifestations treatment methods imiquimod aldara vartocid immunomodulation therapy Infectious and parasitic diseases RC109-216 V. S. Smirnov T. A. Kudryavtseva Treatment of human papillomavirus infection in HIV-infected patients
description	The first reports about HIV (human immunodeficiency virus) were appeared to the 1980s. By 2017 more than 37 million people were living with HIV. Human papilloma virus (HPV) is universally spread, with some estimates showing that about 1% of the sexually active population having genital warts. Human papilloma virus (HPV)-induced infection frequently accompanies the clinical course of HIV and can manifest itself in a full spectrum of clinical-pathologic forms ranging from common warts to malignant neoplasia. Due to the widespread use of antiretroviral therapy, the number of patients with a combined infection (HIV+HPV) is steadily increasing. Here we review current clinical treatment options for HPV manifestations. High-dose antiretroviral therapy does not impede HPV treatment, and can even improve its efficacy in some cases. The topical administration of imiquimod, an immune response modifier, is an effective conservative treatment in HIV-infected patients with HPV. The immunomodulation therapy of imiquimod can serve as an effective alternative of aggressive chemical and mechanical procedures. Maximum efficacy with the lowest replaces rates may be expected from combined use of mechanical ablation methods with a subsequent follow up treatment with imiqui-mod. The best therapeutic result is expected in HIV-positive patients who are received high-dose antiretroviral treatment. The advantages of Vartocid, the modified Russian equivalent of the generic imiquimod.
format	article
author	V. S. Smirnov T. A. Kudryavtseva
author_facet	V. S. Smirnov T. A. Kudryavtseva
author_sort	V. S. Smirnov
title	Treatment of human papillomavirus infection in HIV-infected patients
title_short	Treatment of human papillomavirus infection in HIV-infected patients
title_full	Treatment of human papillomavirus infection in HIV-infected patients
title_fullStr	Treatment of human papillomavirus infection in HIV-infected patients
title_full_unstemmed	Treatment of human papillomavirus infection in HIV-infected patients
title_sort	treatment of human papillomavirus infection in hiv-infected patients
publisher	Sankt-Peterburg : NIIÈM imeni Pastera
publishDate	2021
url	https://doaj.org/article/01e46969b978452c853cbace7062fc58
work_keys_str_mv	AT vssmirnov treatmentofhumanpapillomavirusinfectioninhivinfectedpatients AT takudryavtseva treatmentofhumanpapillomavirusinfectioninhivinfectedpatients
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Treatment of human papillomavirus infection in HIV-infected patients

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