Comparison between Autologous Blood and Fibrin Glue for Adhering Conjunctival Autografts after Pterygium Excision - A Randomised Clinical Trial
Introduction: Fibrin glue is a biological tissue adhesive and acts on the principle of final stages of the coagulation cascade. The cost of commercially available products is very high and not affordable for the patients of low socio-economic strata. As an alternative, pterygium surgery was done...
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| Autores principales: | , |
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| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
JCDR Research and Publications Private Limited
2021
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/01e510441ef24056bcde6f5166be1f76 |
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| Sumario: | Introduction: Fibrin glue is a biological tissue adhesive and acts
on the principle of final stages of the coagulation cascade. The
cost of commercially available products is very high and not
affordable for the patients of low socio-economic strata. As an
alternative, pterygium surgery was done using patient’s own
blood to adhere the conjunctival autograft to scleral bed by the
process of coagulation of fibrin from the oozing blood from the
blood vessels under the flap.
Aim: To compare autologous blood and fibrin glue for adhering
conjunctival autografts after pterygium excision.
Materials and Methods: It was a randomised clinical trial. Total 97
subjects with primary pterygium who visited the Ophthalmology
Department were randomised into two groups. In group A (n=31),
patients had undergone pterygium excision wherein conjunctival
autograft was attached by fibrin glue. In group B (n=66) the graft
was attached by autologous blood present on the scleral bed.
Mean operative time for the procedures were compared. Followup was done for 12 months and all subjects were examined for
postoperative pain, foreign body sensation, inflammation, graft
stability and recurrence.
Results: The mean age of patients in group A was 48.32±14.3
years (21-65 years), and in group B was 54.48±15.67 (23-74
years). Mean operating time in group A was 23.21±9.4 minutes
and 13.7±4.3 minutes in group B, (p-value=0.001). Postoperative
pain of mild degree was present in all the 31 (100%) subjects
of group A. In group B, pain was absent in 32 (48.5%) and mild
degree in 34 (51.5%) subjects. No recurrence was found in both
the groups. Mean follow-up period was 11.4 months.
Conclusion: This study concludes that autologous blood is
a useful alternative method for graft attachment in pterygium
surgery without the untoward complications related to fibrin glue. |
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