Comparison between Autologous Blood and Fibrin Glue for Adhering Conjunctival Autografts after Pterygium Excision - A Randomised Clinical Trial

Introduction: Fibrin glue is a biological tissue adhesive and acts on the principle of final stages of the coagulation cascade. The cost of commercially available products is very high and not affordable for the patients of low socio-economic strata. As an alternative, pterygium surgery was done...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Mona Sune, Pradeep Sune
Formato:	article
Lenguaje:	EN
Publicado:	JCDR Research and Publications Private Limited 2021
Materias:	biological adhesives blood components grafts pterygium surgery Medicine R
Acceso en línea:	https://doaj.org/article/01e510441ef24056bcde6f5166be1f76
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:01e510441ef24056bcde6f5166be1f76
record_format	dspace
spelling	oai:doaj.org-article:01e510441ef24056bcde6f5166be1f762021-11-11T10:22:06ZComparison between Autologous Blood and Fibrin Glue for Adhering Conjunctival Autografts after Pterygium Excision - A Randomised Clinical Trial10.7860/JCDR/2021/46334.153272249-782X0973-709Xhttps://doaj.org/article/01e510441ef24056bcde6f5166be1f762021-09-01T00:00:00Zhttps://www.jcdr.net/articles/PDF/15327/46334_CE[Ra1]_F[SK]_PF1(SG_OM_KM)_PN(KM).pdfhttps://doaj.org/toc/2249-782Xhttps://doaj.org/toc/0973-709XIntroduction: Fibrin glue is a biological tissue adhesive and acts on the principle of final stages of the coagulation cascade. The cost of commercially available products is very high and not affordable for the patients of low socio-economic strata. As an alternative, pterygium surgery was done using patient’s own blood to adhere the conjunctival autograft to scleral bed by the process of coagulation of fibrin from the oozing blood from the blood vessels under the flap. Aim: To compare autologous blood and fibrin glue for adhering conjunctival autografts after pterygium excision. Materials and Methods: It was a randomised clinical trial. Total 97 subjects with primary pterygium who visited the Ophthalmology Department were randomised into two groups. In group A (n=31), patients had undergone pterygium excision wherein conjunctival autograft was attached by fibrin glue. In group B (n=66) the graft was attached by autologous blood present on the scleral bed. Mean operative time for the procedures were compared. Followup was done for 12 months and all subjects were examined for postoperative pain, foreign body sensation, inflammation, graft stability and recurrence. Results: The mean age of patients in group A was 48.32±14.3 years (21-65 years), and in group B was 54.48±15.67 (23-74 years). Mean operating time in group A was 23.21±9.4 minutes and 13.7±4.3 minutes in group B, (p-value=0.001). Postoperative pain of mild degree was present in all the 31 (100%) subjects of group A. In group B, pain was absent in 32 (48.5%) and mild degree in 34 (51.5%) subjects. No recurrence was found in both the groups. Mean follow-up period was 11.4 months. Conclusion: This study concludes that autologous blood is a useful alternative method for graft attachment in pterygium surgery without the untoward complications related to fibrin glue.Mona Sune Pradeep SuneJCDR Research and Publications Private Limitedarticlebiological adhesivesblood componentsgraftspterygium surgeryMedicineRENJournal of Clinical and Diagnostic Research, Vol 15, Iss 9, Pp NC01-NC04 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	biological adhesives blood components grafts pterygium surgery Medicine R
spellingShingle	biological adhesives blood components grafts pterygium surgery Medicine R Mona Sune Pradeep Sune Comparison between Autologous Blood and Fibrin Glue for Adhering Conjunctival Autografts after Pterygium Excision - A Randomised Clinical Trial
description	Introduction: Fibrin glue is a biological tissue adhesive and acts on the principle of final stages of the coagulation cascade. The cost of commercially available products is very high and not affordable for the patients of low socio-economic strata. As an alternative, pterygium surgery was done using patient’s own blood to adhere the conjunctival autograft to scleral bed by the process of coagulation of fibrin from the oozing blood from the blood vessels under the flap. Aim: To compare autologous blood and fibrin glue for adhering conjunctival autografts after pterygium excision. Materials and Methods: It was a randomised clinical trial. Total 97 subjects with primary pterygium who visited the Ophthalmology Department were randomised into two groups. In group A (n=31), patients had undergone pterygium excision wherein conjunctival autograft was attached by fibrin glue. In group B (n=66) the graft was attached by autologous blood present on the scleral bed. Mean operative time for the procedures were compared. Followup was done for 12 months and all subjects were examined for postoperative pain, foreign body sensation, inflammation, graft stability and recurrence. Results: The mean age of patients in group A was 48.32±14.3 years (21-65 years), and in group B was 54.48±15.67 (23-74 years). Mean operating time in group A was 23.21±9.4 minutes and 13.7±4.3 minutes in group B, (p-value=0.001). Postoperative pain of mild degree was present in all the 31 (100%) subjects of group A. In group B, pain was absent in 32 (48.5%) and mild degree in 34 (51.5%) subjects. No recurrence was found in both the groups. Mean follow-up period was 11.4 months. Conclusion: This study concludes that autologous blood is a useful alternative method for graft attachment in pterygium surgery without the untoward complications related to fibrin glue.
format	article
author	Mona Sune Pradeep Sune
author_facet	Mona Sune Pradeep Sune
author_sort	Mona Sune
title	Comparison between Autologous Blood and Fibrin Glue for Adhering Conjunctival Autografts after Pterygium Excision - A Randomised Clinical Trial
title_short	Comparison between Autologous Blood and Fibrin Glue for Adhering Conjunctival Autografts after Pterygium Excision - A Randomised Clinical Trial
title_full	Comparison between Autologous Blood and Fibrin Glue for Adhering Conjunctival Autografts after Pterygium Excision - A Randomised Clinical Trial
title_fullStr	Comparison between Autologous Blood and Fibrin Glue for Adhering Conjunctival Autografts after Pterygium Excision - A Randomised Clinical Trial
title_full_unstemmed	Comparison between Autologous Blood and Fibrin Glue for Adhering Conjunctival Autografts after Pterygium Excision - A Randomised Clinical Trial
title_sort	comparison between autologous blood and fibrin glue for adhering conjunctival autografts after pterygium excision - a randomised clinical trial
publisher	JCDR Research and Publications Private Limited
publishDate	2021
url	https://doaj.org/article/01e510441ef24056bcde6f5166be1f76
work_keys_str_mv	AT monasune comparisonbetweenautologousbloodandfibringlueforadheringconjunctivalautograftsafterpterygiumexcisionarandomisedclinicaltrial AT pradeepsune comparisonbetweenautologousbloodandfibringlueforadheringconjunctivalautograftsafterpterygiumexcisionarandomisedclinicaltrial
_version_	1718439186778816512

Comparison between Autologous Blood and Fibrin Glue for Adhering Conjunctival Autografts after Pterygium Excision - A Randomised Clinical Trial

Ejemplares similares