High hydrostatic pressure shapes the development and production of secondary metabolites of Mariana Trench sediment fungi

Abstract The hadal biosphere is one of the least understood ecosystems on our planet. Recent studies have revealed diverse and active communities of prokaryotes in hadal sediment. However, there have been few studies on fungi in hadal sediment. Here we report the first isolation and cultivation of 8...

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Autores principales:	Qingqing Peng, Yongqi Li, Ludan Deng, Jiasong Fang, Xi Yu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/01e5a2a432024c78a05e98af3a6f7356
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spelling	oai:doaj.org-article:01e5a2a432024c78a05e98af3a6f73562021-12-02T18:25:03ZHigh hydrostatic pressure shapes the development and production of secondary metabolites of Mariana Trench sediment fungi10.1038/s41598-021-90920-12045-2322https://doaj.org/article/01e5a2a432024c78a05e98af3a6f73562021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-90920-1https://doaj.org/toc/2045-2322Abstract The hadal biosphere is one of the least understood ecosystems on our planet. Recent studies have revealed diverse and active communities of prokaryotes in hadal sediment. However, there have been few studies on fungi in hadal sediment. Here we report the first isolation and cultivation of 8 fungi from the Mariana Trench sediment. The individual colonies were isolated and identified as Stemphylium sp., Cladosporium sp., Arthrinium sp., Fusarium sp., Alternaria sp., and Aspergillus sp. High hydrostatic pressure (HHP) test was carried out to identify the piezophily of these hadal fungi. Among them, 7 out of the 8 fungal isolates exhibited the ability of germination after incubation under 40 MPa for 7 days. Vegetative growth of the isolates was also affected by HHP. Characterization of secondary metabolites under different pressure conditions was also performed. The production of secondary metabolites was affected by the HHP treatment, improving the potential of discovering novel natural products from hadal fungi. The antibacterial assay revealed the potential of discovering novel natural products. Our results suggest that fungal growth pressure plays an important role in the development and production of secondary metabolites of these hadal fungi under the extreme environment in the Mariana Trench.Qingqing PengYongqi LiLudan DengJiasong FangXi YuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Qingqing Peng Yongqi Li Ludan Deng Jiasong Fang Xi Yu High hydrostatic pressure shapes the development and production of secondary metabolites of Mariana Trench sediment fungi
description	Abstract The hadal biosphere is one of the least understood ecosystems on our planet. Recent studies have revealed diverse and active communities of prokaryotes in hadal sediment. However, there have been few studies on fungi in hadal sediment. Here we report the first isolation and cultivation of 8 fungi from the Mariana Trench sediment. The individual colonies were isolated and identified as Stemphylium sp., Cladosporium sp., Arthrinium sp., Fusarium sp., Alternaria sp., and Aspergillus sp. High hydrostatic pressure (HHP) test was carried out to identify the piezophily of these hadal fungi. Among them, 7 out of the 8 fungal isolates exhibited the ability of germination after incubation under 40 MPa for 7 days. Vegetative growth of the isolates was also affected by HHP. Characterization of secondary metabolites under different pressure conditions was also performed. The production of secondary metabolites was affected by the HHP treatment, improving the potential of discovering novel natural products from hadal fungi. The antibacterial assay revealed the potential of discovering novel natural products. Our results suggest that fungal growth pressure plays an important role in the development and production of secondary metabolites of these hadal fungi under the extreme environment in the Mariana Trench.
format	article
author	Qingqing Peng Yongqi Li Ludan Deng Jiasong Fang Xi Yu
author_facet	Qingqing Peng Yongqi Li Ludan Deng Jiasong Fang Xi Yu
author_sort	Qingqing Peng
title	High hydrostatic pressure shapes the development and production of secondary metabolites of Mariana Trench sediment fungi
title_short	High hydrostatic pressure shapes the development and production of secondary metabolites of Mariana Trench sediment fungi
title_full	High hydrostatic pressure shapes the development and production of secondary metabolites of Mariana Trench sediment fungi
title_fullStr	High hydrostatic pressure shapes the development and production of secondary metabolites of Mariana Trench sediment fungi
title_full_unstemmed	High hydrostatic pressure shapes the development and production of secondary metabolites of Mariana Trench sediment fungi
title_sort	high hydrostatic pressure shapes the development and production of secondary metabolites of mariana trench sediment fungi
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/01e5a2a432024c78a05e98af3a6f7356
work_keys_str_mv	AT qingqingpeng highhydrostaticpressureshapesthedevelopmentandproductionofsecondarymetabolitesofmarianatrenchsedimentfungi AT yongqili highhydrostaticpressureshapesthedevelopmentandproductionofsecondarymetabolitesofmarianatrenchsedimentfungi AT ludandeng highhydrostaticpressureshapesthedevelopmentandproductionofsecondarymetabolitesofmarianatrenchsedimentfungi AT jiasongfang highhydrostaticpressureshapesthedevelopmentandproductionofsecondarymetabolitesofmarianatrenchsedimentfungi AT xiyu highhydrostaticpressureshapesthedevelopmentandproductionofsecondarymetabolitesofmarianatrenchsedimentfungi
_version_	1718378018260385792

High hydrostatic pressure shapes the development and production of secondary metabolites of Mariana Trench sediment fungi

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