Hidden heterogeneity and circadian-controlled cell fate inferred from single cell lineages

The origins of lineage correlations and heterogeneity in division and apoptosis times among single cells are incompletely understood. Here, a new lineage tracking data analysis approach reveals that circadian oscillations may underlie cell fate control and explain the observed correlation structures...

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Autores principales: Shaon Chakrabarti, Andrew L. Paek, Jose Reyes, Kathleen A. Lasick, Galit Lahav, Franziska Michor
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/01e9efd3bfb140d087a5b3c73a4ee514
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Sumario:The origins of lineage correlations and heterogeneity in division and apoptosis times among single cells are incompletely understood. Here, a new lineage tracking data analysis approach reveals that circadian oscillations may underlie cell fate control and explain the observed correlation structures.