Renal tubular cell necroptosis: A novel mechanism of kidney damage in trichloroethylene hypersensitivity syndrome mice

Trichloroethylene (TCE) hypersensitivity syndrome (THS), called occupational medicamentosa-like dermatitis due to TCE (OMDT) in China, is a fatal occupational disorder caused by TCE exposure. Visceral damage, including kidney injury, is one of the major complications. Necroptosis is a regulated cell...

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Autores principales:	Yican Wang, Meng Huang, Xin Du, Yiting Hong, Liping Huang, Yuying Dai, Qifeng Wu, Feng Wang, Qixing Zhu
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2021
Materias:	trichloroethylene hypersensitivity syndrome trichloroethylene renal tubular epithelial cell necroptosis tumor necrosis factor Immunologic diseases. Allergy RC581-607 Toxicology. Poisons RA1190-1270
Acceso en línea:	https://doaj.org/article/01ea26df51c149bc9a4bc3fccf6f7793
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spelling	oai:doaj.org-article:01ea26df51c149bc9a4bc3fccf6f77932021-11-26T11:19:47ZRenal tubular cell necroptosis: A novel mechanism of kidney damage in trichloroethylene hypersensitivity syndrome mice1547-691X1547-690110.1080/1547691X.2021.2003486https://doaj.org/article/01ea26df51c149bc9a4bc3fccf6f77932021-01-01T00:00:00Zhttp://dx.doi.org/10.1080/1547691X.2021.2003486https://doaj.org/toc/1547-691Xhttps://doaj.org/toc/1547-6901Trichloroethylene (TCE) hypersensitivity syndrome (THS), called occupational medicamentosa-like dermatitis due to TCE (OMDT) in China, is a fatal occupational disorder caused by TCE exposure. Visceral damage, including kidney injury, is one of the major complications. Necroptosis is a regulated cell death form linked to local inflammatory response. This study aimed to investigate whether renal cell necroptosis was involved in TCE-induced kidney injury. A Balb/c mouse model of TCE sensitization was utilized to study mechanisms of modulation of TCE-induced renal necroptosis. Renal histology (using light and transmission electron microscopy) and renal tubular impairment indexes, including α1-microglobulin (α1-MG), and β2-microglobulin (β2-MG), were evaluated. In addition, tissue expression of necroptosis-related proteins, including tumor necrosis factor (TNF)-α, TNF receptor 1 (TNFR1), receptor-interacting protein kinase 3 (RIPK3), p-RIK3, mixed lineage kinase domain-like protein (MLKL), and p-MLKL, were also evaluated. The study here confirmed TCE sensitization caused damage to renal tubules and renal tubular epithelial cell (RTEC) necroptosis. In mice treated with R7050 (a specific TNFα antagonist), it was also seen that inhibition of TNFα expression could effectively inhibit RTEC necroptosis and improve renal function in the TCE-sensitized mice. Taken together, these results help to define a novel mechanism by which RTEC necroptosis plays a key role in TCE-induced kidney damage.Yican WangMeng HuangXin DuYiting HongLiping HuangYuying DaiQifeng WuFeng WangQixing ZhuTaylor & Francis Grouparticletrichloroethylene hypersensitivity syndrometrichloroethylenerenal tubular epithelial cellnecroptosistumor necrosis factorImmunologic diseases. AllergyRC581-607Toxicology. PoisonsRA1190-1270ENJournal of Immunotoxicology, Vol 18, Iss 1, Pp 173-182 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	trichloroethylene hypersensitivity syndrome trichloroethylene renal tubular epithelial cell necroptosis tumor necrosis factor Immunologic diseases. Allergy RC581-607 Toxicology. Poisons RA1190-1270
spellingShingle	trichloroethylene hypersensitivity syndrome trichloroethylene renal tubular epithelial cell necroptosis tumor necrosis factor Immunologic diseases. Allergy RC581-607 Toxicology. Poisons RA1190-1270 Yican Wang Meng Huang Xin Du Yiting Hong Liping Huang Yuying Dai Qifeng Wu Feng Wang Qixing Zhu Renal tubular cell necroptosis: A novel mechanism of kidney damage in trichloroethylene hypersensitivity syndrome mice
description	Trichloroethylene (TCE) hypersensitivity syndrome (THS), called occupational medicamentosa-like dermatitis due to TCE (OMDT) in China, is a fatal occupational disorder caused by TCE exposure. Visceral damage, including kidney injury, is one of the major complications. Necroptosis is a regulated cell death form linked to local inflammatory response. This study aimed to investigate whether renal cell necroptosis was involved in TCE-induced kidney injury. A Balb/c mouse model of TCE sensitization was utilized to study mechanisms of modulation of TCE-induced renal necroptosis. Renal histology (using light and transmission electron microscopy) and renal tubular impairment indexes, including α1-microglobulin (α1-MG), and β2-microglobulin (β2-MG), were evaluated. In addition, tissue expression of necroptosis-related proteins, including tumor necrosis factor (TNF)-α, TNF receptor 1 (TNFR1), receptor-interacting protein kinase 3 (RIPK3), p-RIK3, mixed lineage kinase domain-like protein (MLKL), and p-MLKL, were also evaluated. The study here confirmed TCE sensitization caused damage to renal tubules and renal tubular epithelial cell (RTEC) necroptosis. In mice treated with R7050 (a specific TNFα antagonist), it was also seen that inhibition of TNFα expression could effectively inhibit RTEC necroptosis and improve renal function in the TCE-sensitized mice. Taken together, these results help to define a novel mechanism by which RTEC necroptosis plays a key role in TCE-induced kidney damage.
format	article
author	Yican Wang Meng Huang Xin Du Yiting Hong Liping Huang Yuying Dai Qifeng Wu Feng Wang Qixing Zhu
author_facet	Yican Wang Meng Huang Xin Du Yiting Hong Liping Huang Yuying Dai Qifeng Wu Feng Wang Qixing Zhu
author_sort	Yican Wang
title	Renal tubular cell necroptosis: A novel mechanism of kidney damage in trichloroethylene hypersensitivity syndrome mice
title_short	Renal tubular cell necroptosis: A novel mechanism of kidney damage in trichloroethylene hypersensitivity syndrome mice
title_full	Renal tubular cell necroptosis: A novel mechanism of kidney damage in trichloroethylene hypersensitivity syndrome mice
title_fullStr	Renal tubular cell necroptosis: A novel mechanism of kidney damage in trichloroethylene hypersensitivity syndrome mice
title_full_unstemmed	Renal tubular cell necroptosis: A novel mechanism of kidney damage in trichloroethylene hypersensitivity syndrome mice
title_sort	renal tubular cell necroptosis: a novel mechanism of kidney damage in trichloroethylene hypersensitivity syndrome mice
publisher	Taylor & Francis Group
publishDate	2021
url	https://doaj.org/article/01ea26df51c149bc9a4bc3fccf6f7793
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Renal tubular cell necroptosis: A novel mechanism of kidney damage in trichloroethylene hypersensitivity syndrome mice

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