Endothelial eNAMPT drives EndMT and preclinical PH: rescue by an eNAMPT-neutralizing mAb

Endothelial eNAMPT drives EndMT and preclinical PH: rescue by an eNAMPT-neutralizing mAb

Pharmacologic interventions to halt/reverse the vascular remodeling and right ventricular dysfunction in pulmonary arterial hypertension (PAH) remains an unmet need. We previously demonstrated extracellular nicotinamide phosphoribosyltransferase (eNAMPT) as a DAMP (damage-associated molecular patter...

Full description

Saved in:
Bibliographic Details
Main Authors: Mohamed Ahmed, Nahla Zaghloul, Prisca Zimmerman, Nancy G. Casanova, Xiaoguang Sun, Jin H. Song, Vivian Reyes Hernon, Saad Sammani, Franz Rischard, Olga Rafikova, Ruslan Rafikov, Ayako Makino, Carrie L. Kempf, Sara M. Camp, Jian Wang, Ankit A. Desai, Yves Lussier, Jason X.-J. Yuan, Joe G.N. Garcia
Format: article
Language:EN
Published: SAGE Publishing 2021
Subjects:
Diseases of the circulatory (Cardiovascular) system
RC666-701
Diseases of the respiratory system
RC705-779
Online Access:https://doaj.org/article/01ea69ffb6ab44d592257d77dde80f26
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doaj.org/article/01ea69ffb6ab44d592257d77dde80f26

Similar Items