25-Hydroxycholesterol Inhibition of Lassa Virus Infection through Aberrant GP1 Glycosylation

25-Hydroxycholesterol Inhibition of Lassa Virus Infection through Aberrant GP1 Glycosylation

ABSTRACT Lassa virus (LASV) infection is a major public health concern due to high fatality rates and limited effective treatment. The interferon-stimulated gene cholesterol 25-hydroxylase (CH25H) encodes an enzyme that catalyzes the production of 25-hydroxycholesterol (25HC). 25HC is involved in re...

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Autores principales: Punya Shrivastava-Ranjan, Éric Bergeron, Ayan K. Chakrabarti, César G. Albariño, Mike Flint, Stuart T. Nichol, Christina F. Spiropoulou
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2016
Materias:
Microbiology
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Acceso en línea:https://doaj.org/article/01ee617f60b44badb3c1a12fba3b49d9
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