Polarity signaling ensures epidermal homeostasis by coupling cellular mechanics and genomic integrity

Many developing tissues require Par-driven polarization, but its role in mammalian tissue maintenance is unclear. Here, the authors show that in mouse epidermis, Par3 governs tissue homeostasis not via orientation of cell division but by coupling cell mechanics with mitotic accuracy and genome integ...

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Autores principales:	Martim Dias Gomes, Soriba Letzian, Michael Saynisch, Sandra Iden
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/01f3c0959d3e463a953531f3edee330c
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spelling	oai:doaj.org-article:01f3c0959d3e463a953531f3edee330c2021-12-02T14:38:43ZPolarity signaling ensures epidermal homeostasis by coupling cellular mechanics and genomic integrity10.1038/s41467-019-11325-32041-1723https://doaj.org/article/01f3c0959d3e463a953531f3edee330c2019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11325-3https://doaj.org/toc/2041-1723Many developing tissues require Par-driven polarization, but its role in mammalian tissue maintenance is unclear. Here, the authors show that in mouse epidermis, Par3 governs tissue homeostasis not via orientation of cell division but by coupling cell mechanics with mitotic accuracy and genome integrity.Martim Dias GomesSoriba LetzianMichael SaynischSandra IdenNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Martim Dias Gomes Soriba Letzian Michael Saynisch Sandra Iden Polarity signaling ensures epidermal homeostasis by coupling cellular mechanics and genomic integrity
description	Many developing tissues require Par-driven polarization, but its role in mammalian tissue maintenance is unclear. Here, the authors show that in mouse epidermis, Par3 governs tissue homeostasis not via orientation of cell division but by coupling cell mechanics with mitotic accuracy and genome integrity.
format	article
author	Martim Dias Gomes Soriba Letzian Michael Saynisch Sandra Iden
author_facet	Martim Dias Gomes Soriba Letzian Michael Saynisch Sandra Iden
author_sort	Martim Dias Gomes
title	Polarity signaling ensures epidermal homeostasis by coupling cellular mechanics and genomic integrity
title_short	Polarity signaling ensures epidermal homeostasis by coupling cellular mechanics and genomic integrity
title_full	Polarity signaling ensures epidermal homeostasis by coupling cellular mechanics and genomic integrity
title_fullStr	Polarity signaling ensures epidermal homeostasis by coupling cellular mechanics and genomic integrity
title_full_unstemmed	Polarity signaling ensures epidermal homeostasis by coupling cellular mechanics and genomic integrity
title_sort	polarity signaling ensures epidermal homeostasis by coupling cellular mechanics and genomic integrity
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/01f3c0959d3e463a953531f3edee330c
work_keys_str_mv	AT martimdiasgomes polaritysignalingensuresepidermalhomeostasisbycouplingcellularmechanicsandgenomicintegrity AT soribaletzian polaritysignalingensuresepidermalhomeostasisbycouplingcellularmechanicsandgenomicintegrity AT michaelsaynisch polaritysignalingensuresepidermalhomeostasisbycouplingcellularmechanicsandgenomicintegrity AT sandraiden polaritysignalingensuresepidermalhomeostasisbycouplingcellularmechanicsandgenomicintegrity
_version_	1718390871941971968

Polarity signaling ensures epidermal homeostasis by coupling cellular mechanics and genomic integrity

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