Morphologic Classifications and Locations of Microaneurysms and Clinical Relevance in Branch Retinal Vein Occlusion

Yuya Esaki, Yoshio Hirano, Ryo Kurobe, Yusuke Yasuda, Taneto Tomiyasu, Norihiro Suzuki, Tsutomu Yasukawa, Munenori Yoshida, Yuichiro Ogura Department of Ophthalmology & Visual Science, Nagoya City University Graduate School of Medical Sciences, Nagoya, JapanCorrespondence: Yoshio HiranoDepar...

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Autores principales:	Esaki Y, Hirano Y, Kurobe R, Yasuda Y, Tomiyasu T, Suzuki N, Yasukawa T, Yoshida M, Ogura Y
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	microaneurysm morphology macular edema optical coherence tomography angiography branch retinal vein occlusion. Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/01f4f01724194873b90b57fed06a50d3
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spelling	oai:doaj.org-article:01f4f01724194873b90b57fed06a50d32021-12-02T13:13:10ZMorphologic Classifications and Locations of Microaneurysms and Clinical Relevance in Branch Retinal Vein Occlusion1177-5483https://doaj.org/article/01f4f01724194873b90b57fed06a50d32020-07-01T00:00:00Zhttps://www.dovepress.com/morphologic-classifications-and-locations-of-microaneurysms-and-clinic-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Yuya Esaki, Yoshio Hirano, Ryo Kurobe, Yusuke Yasuda, Taneto Tomiyasu, Norihiro Suzuki, Tsutomu Yasukawa, Munenori Yoshida, Yuichiro Ogura Department of Ophthalmology & Visual Science, Nagoya City University Graduate School of Medical Sciences, Nagoya, JapanCorrespondence: Yoshio HiranoDepartment of Ophthalmology & Visual Science, Nagoya City University Graduate School of Medical Sciences, 1-Kawasumi, Mizuho-Cho, Mizuho-Ku, Nagoya 467-8601, JapanTel +81 52-8538251Fax +81 52-8419490Email yoshio.hirano@gmail.comPurpose: To classify microaneurysms (MAs) and investigate the relationships with retinal edema in eyes with branch retinal vein occlusion (BRVO).Study Design: Retrospective, observational, consecutive case series.Methods: Eyes with MAs due to BRVO that underwent optical coherence tomography angiography (OCTA) were enrolled. MAs on OCTA images were morphologically classified into six types: focal bulge, saccular, fusiform, mixed (saccular/fusiform), pedunculated, and irregular. The frequency, size, location, and relationships with retinal edema also were investigated.Results: Twenty-four eyes of 23 patients (12 men, 11 women; mean age, 68.0 years) were enrolled. A total of 244 MAs were detected on the OCTA images. The focal bulge and saccular types accounted for over 70% of all MAs. Smaller MAs such as the focal bulge or saccular type also were detected both at the edge of the nonperfused areas (NPAs) and in collateral vessels. In contrast, larger MAs such as the pedunculated or irregular types tended to form at the edges of the NPAs. Older age, the presence of MAs in the collateral vessels, and the absence of pedunculated type were independent predictive factors for retinal edema but not the MA size, or presence in the retinal deep capillary plexus. After treatment, the mean retinal thickness decreased significantly, but the mean MA size remained unchanged.Conclusion: OCTA enables morphologic classification, three-dimensional analysis, and investigation of the longitudinal changes of MAs with noninvasive volumetric quantification, leading to a better understanding of the pathology of MAs in eyes with BRVO.Keywords: microaneurysm, morphology, macular edema, optical coherence tomography angiography, branch retinal vein occlusionEsaki YHirano YKurobe RYasuda YTomiyasu TSuzuki NYasukawa TYoshida MOgura YDove Medical Pressarticlemicroaneurysmmorphologymacular edemaoptical coherence tomography angiographybranch retinal vein occlusion.OphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 14, Pp 1909-1919 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	microaneurysm morphology macular edema optical coherence tomography angiography branch retinal vein occlusion. Ophthalmology RE1-994
spellingShingle	microaneurysm morphology macular edema optical coherence tomography angiography branch retinal vein occlusion. Ophthalmology RE1-994 Esaki Y Hirano Y Kurobe R Yasuda Y Tomiyasu T Suzuki N Yasukawa T Yoshida M Ogura Y Morphologic Classifications and Locations of Microaneurysms and Clinical Relevance in Branch Retinal Vein Occlusion
description	Yuya Esaki, Yoshio Hirano, Ryo Kurobe, Yusuke Yasuda, Taneto Tomiyasu, Norihiro Suzuki, Tsutomu Yasukawa, Munenori Yoshida, Yuichiro Ogura Department of Ophthalmology & Visual Science, Nagoya City University Graduate School of Medical Sciences, Nagoya, JapanCorrespondence: Yoshio HiranoDepartment of Ophthalmology & Visual Science, Nagoya City University Graduate School of Medical Sciences, 1-Kawasumi, Mizuho-Cho, Mizuho-Ku, Nagoya 467-8601, JapanTel +81 52-8538251Fax +81 52-8419490Email yoshio.hirano@gmail.comPurpose: To classify microaneurysms (MAs) and investigate the relationships with retinal edema in eyes with branch retinal vein occlusion (BRVO).Study Design: Retrospective, observational, consecutive case series.Methods: Eyes with MAs due to BRVO that underwent optical coherence tomography angiography (OCTA) were enrolled. MAs on OCTA images were morphologically classified into six types: focal bulge, saccular, fusiform, mixed (saccular/fusiform), pedunculated, and irregular. The frequency, size, location, and relationships with retinal edema also were investigated.Results: Twenty-four eyes of 23 patients (12 men, 11 women; mean age, 68.0 years) were enrolled. A total of 244 MAs were detected on the OCTA images. The focal bulge and saccular types accounted for over 70% of all MAs. Smaller MAs such as the focal bulge or saccular type also were detected both at the edge of the nonperfused areas (NPAs) and in collateral vessels. In contrast, larger MAs such as the pedunculated or irregular types tended to form at the edges of the NPAs. Older age, the presence of MAs in the collateral vessels, and the absence of pedunculated type were independent predictive factors for retinal edema but not the MA size, or presence in the retinal deep capillary plexus. After treatment, the mean retinal thickness decreased significantly, but the mean MA size remained unchanged.Conclusion: OCTA enables morphologic classification, three-dimensional analysis, and investigation of the longitudinal changes of MAs with noninvasive volumetric quantification, leading to a better understanding of the pathology of MAs in eyes with BRVO.Keywords: microaneurysm, morphology, macular edema, optical coherence tomography angiography, branch retinal vein occlusion
format	article
author	Esaki Y Hirano Y Kurobe R Yasuda Y Tomiyasu T Suzuki N Yasukawa T Yoshida M Ogura Y
author_facet	Esaki Y Hirano Y Kurobe R Yasuda Y Tomiyasu T Suzuki N Yasukawa T Yoshida M Ogura Y
author_sort	Esaki Y
title	Morphologic Classifications and Locations of Microaneurysms and Clinical Relevance in Branch Retinal Vein Occlusion
title_short	Morphologic Classifications and Locations of Microaneurysms and Clinical Relevance in Branch Retinal Vein Occlusion
title_full	Morphologic Classifications and Locations of Microaneurysms and Clinical Relevance in Branch Retinal Vein Occlusion
title_fullStr	Morphologic Classifications and Locations of Microaneurysms and Clinical Relevance in Branch Retinal Vein Occlusion
title_full_unstemmed	Morphologic Classifications and Locations of Microaneurysms and Clinical Relevance in Branch Retinal Vein Occlusion
title_sort	morphologic classifications and locations of microaneurysms and clinical relevance in branch retinal vein occlusion
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/01f4f01724194873b90b57fed06a50d3
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Morphologic Classifications and Locations of Microaneurysms and Clinical Relevance in Branch Retinal Vein Occlusion

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