Early Gut Microbiota Colonisation of Premature Infants Fed with Breastmilk or Formula with or without Probiotics: A Cohort Study

Premature infants have a fragile ecology of the gut microbiota, which is associated with many health problems and may be influenced by formula versus breast feeding. The present study investigated differences in the process of gut microbiota colonisation in preterm infants fed with breastmilk or for...

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Autores principales:	Cheng Chi, Yali Fan, Cheng Li, Yu Li, Shan Guo, Tianhe Li, Nicholas Buys, Vicki L. Clifton, Paul B. Colditz, Chenghong Yin, Jing Sun
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	microbiota probiotics preterm infants Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/01f878ac792b4d0e9f0ea98982764922
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spelling	oai:doaj.org-article:01f878ac792b4d0e9f0ea989827649222021-11-25T18:36:31ZEarly Gut Microbiota Colonisation of Premature Infants Fed with Breastmilk or Formula with or without Probiotics: A Cohort Study10.3390/nu131140682072-6643https://doaj.org/article/01f878ac792b4d0e9f0ea989827649222021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6643/13/11/4068https://doaj.org/toc/2072-6643Premature infants have a fragile ecology of the gut microbiota, which is associated with many health problems and may be influenced by formula versus breast feeding. The present study investigated differences in the process of gut microbiota colonisation in preterm infants fed with breastmilk or formula with or without probiotics before 12 weeks. This cohort study recruited 138 premature infants; 31 in the breastmilk (BM) group, 59 in the probiotics formula (PF) group and 48 in the non-probiotics formula (NPF) group, according to the feeding practice they received at birth. Gut bacterial composition was identified with 16S rRNA gene sequencing in faecal samples collected at 1 week, 6 weeks and 12 weeks after birth. The alpha diversity was higher in the PF group compared to the other groups at week 1 and 6 (both <i>p</i> < 0.01) but showed no difference at week 12. The beta diversity of the three groups showed a trend towards similarity at the first two stages (<i>p</i> < 0.001 and <i>p</i> = 0.009, respectively) and finally showed no difference at week 12. Canonical redundancy analysis showed that feeding type could explain the difference in gut microbiota composition at week one and six (both <i>p</i> < 0.01). At genus level, <i>Bifidobacterium</i> was enriched in the PF group, while the <i>Enterococcus</i> and <i>Streptococcus</i> was enriched in the NPF group. In summary, formula with probiotics feeding after birth can affect gut microbiota colonisation and lead to a bacterial community with less potential pathogens.Cheng ChiYali FanCheng LiYu LiShan GuoTianhe LiNicholas BuysVicki L. CliftonPaul B. ColditzChenghong YinJing SunMDPI AGarticlemicrobiotaprobioticspreterm infantsNutrition. Foods and food supplyTX341-641ENNutrients, Vol 13, Iss 4068, p 4068 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	microbiota probiotics preterm infants Nutrition. Foods and food supply TX341-641
spellingShingle	microbiota probiotics preterm infants Nutrition. Foods and food supply TX341-641 Cheng Chi Yali Fan Cheng Li Yu Li Shan Guo Tianhe Li Nicholas Buys Vicki L. Clifton Paul B. Colditz Chenghong Yin Jing Sun Early Gut Microbiota Colonisation of Premature Infants Fed with Breastmilk or Formula with or without Probiotics: A Cohort Study
description	Premature infants have a fragile ecology of the gut microbiota, which is associated with many health problems and may be influenced by formula versus breast feeding. The present study investigated differences in the process of gut microbiota colonisation in preterm infants fed with breastmilk or formula with or without probiotics before 12 weeks. This cohort study recruited 138 premature infants; 31 in the breastmilk (BM) group, 59 in the probiotics formula (PF) group and 48 in the non-probiotics formula (NPF) group, according to the feeding practice they received at birth. Gut bacterial composition was identified with 16S rRNA gene sequencing in faecal samples collected at 1 week, 6 weeks and 12 weeks after birth. The alpha diversity was higher in the PF group compared to the other groups at week 1 and 6 (both <i>p</i> < 0.01) but showed no difference at week 12. The beta diversity of the three groups showed a trend towards similarity at the first two stages (<i>p</i> < 0.001 and <i>p</i> = 0.009, respectively) and finally showed no difference at week 12. Canonical redundancy analysis showed that feeding type could explain the difference in gut microbiota composition at week one and six (both <i>p</i> < 0.01). At genus level, <i>Bifidobacterium</i> was enriched in the PF group, while the <i>Enterococcus</i> and <i>Streptococcus</i> was enriched in the NPF group. In summary, formula with probiotics feeding after birth can affect gut microbiota colonisation and lead to a bacterial community with less potential pathogens.
format	article
author	Cheng Chi Yali Fan Cheng Li Yu Li Shan Guo Tianhe Li Nicholas Buys Vicki L. Clifton Paul B. Colditz Chenghong Yin Jing Sun
author_facet	Cheng Chi Yali Fan Cheng Li Yu Li Shan Guo Tianhe Li Nicholas Buys Vicki L. Clifton Paul B. Colditz Chenghong Yin Jing Sun
author_sort	Cheng Chi
title	Early Gut Microbiota Colonisation of Premature Infants Fed with Breastmilk or Formula with or without Probiotics: A Cohort Study
title_short	Early Gut Microbiota Colonisation of Premature Infants Fed with Breastmilk or Formula with or without Probiotics: A Cohort Study
title_full	Early Gut Microbiota Colonisation of Premature Infants Fed with Breastmilk or Formula with or without Probiotics: A Cohort Study
title_fullStr	Early Gut Microbiota Colonisation of Premature Infants Fed with Breastmilk or Formula with or without Probiotics: A Cohort Study
title_full_unstemmed	Early Gut Microbiota Colonisation of Premature Infants Fed with Breastmilk or Formula with or without Probiotics: A Cohort Study
title_sort	early gut microbiota colonisation of premature infants fed with breastmilk or formula with or without probiotics: a cohort study
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/01f878ac792b4d0e9f0ea98982764922
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Early Gut Microbiota Colonisation of Premature Infants Fed with Breastmilk or Formula with or without Probiotics: A Cohort Study

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