MAIT cells regulate NK cell-mediated tumor immunity

Mucosal-associated invariant T (MAIT) cells facilitate anti-microbial responses, but their functions in cancer protection is unclear. Here the authors show that activated MAIT cells induce an IFN-γ transcriptome in natural killer (NK) cells and enhance NK-dependent anti-cancer immunity in mice, ther...

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Autores principales:	Emma V. Petley, Hui-Fern Koay, Melissa A. Henderson, Kevin Sek, Kirsten L. Todd, Simon P. Keam, Junyun Lai, Imran G. House, Jasmine Li, Magnus Zethoven, Amanda X. Y. Chen, Amanda J. Oliver, Jessica Michie, Andrew J. Freeman, Lauren Giuffrida, Jack D. Chan, Angela Pizzolla, Jeffrey Y. W. Mak, Timothy R. McCulloch, Fernando Souza-Fonseca-Guimaraes, Conor J. Kearney, Rosemary Millen, Robert G. Ramsay, Nicholas D. Huntington, James McCluskey, Jane Oliaro, David P. Fairlie, Paul J. Neeson, Dale I. Godfrey, Paul A. Beavis, Phillip K. Darcy
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/01f893fc7b8b403cadf95ab8ec274a3e
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id	oai:doaj.org-article:01f893fc7b8b403cadf95ab8ec274a3e
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spelling	oai:doaj.org-article:01f893fc7b8b403cadf95ab8ec274a3e2021-12-02T16:34:05ZMAIT cells regulate NK cell-mediated tumor immunity10.1038/s41467-021-25009-42041-1723https://doaj.org/article/01f893fc7b8b403cadf95ab8ec274a3e2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25009-4https://doaj.org/toc/2041-1723Mucosal-associated invariant T (MAIT) cells facilitate anti-microbial responses, but their functions in cancer protection is unclear. Here the authors show that activated MAIT cells induce an IFN-γ transcriptome in natural killer (NK) cells and enhance NK-dependent anti-cancer immunity in mice, thereby hinting a new avenue for cancer therapy.Emma V. PetleyHui-Fern KoayMelissa A. HendersonKevin SekKirsten L. ToddSimon P. KeamJunyun LaiImran G. HouseJasmine LiMagnus ZethovenAmanda X. Y. ChenAmanda J. OliverJessica MichieAndrew J. FreemanLauren GiuffridaJack D. ChanAngela PizzollaJeffrey Y. W. MakTimothy R. McCullochFernando Souza-Fonseca-GuimaraesConor J. KearneyRosemary MillenRobert G. RamsayNicholas D. HuntingtonJames McCluskeyJane OliaroDavid P. FairliePaul J. NeesonDale I. GodfreyPaul A. BeavisPhillip K. DarcyNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Emma V. Petley Hui-Fern Koay Melissa A. Henderson Kevin Sek Kirsten L. Todd Simon P. Keam Junyun Lai Imran G. House Jasmine Li Magnus Zethoven Amanda X. Y. Chen Amanda J. Oliver Jessica Michie Andrew J. Freeman Lauren Giuffrida Jack D. Chan Angela Pizzolla Jeffrey Y. W. Mak Timothy R. McCulloch Fernando Souza-Fonseca-Guimaraes Conor J. Kearney Rosemary Millen Robert G. Ramsay Nicholas D. Huntington James McCluskey Jane Oliaro David P. Fairlie Paul J. Neeson Dale I. Godfrey Paul A. Beavis Phillip K. Darcy MAIT cells regulate NK cell-mediated tumor immunity
description	Mucosal-associated invariant T (MAIT) cells facilitate anti-microbial responses, but their functions in cancer protection is unclear. Here the authors show that activated MAIT cells induce an IFN-γ transcriptome in natural killer (NK) cells and enhance NK-dependent anti-cancer immunity in mice, thereby hinting a new avenue for cancer therapy.
format	article
author	Emma V. Petley Hui-Fern Koay Melissa A. Henderson Kevin Sek Kirsten L. Todd Simon P. Keam Junyun Lai Imran G. House Jasmine Li Magnus Zethoven Amanda X. Y. Chen Amanda J. Oliver Jessica Michie Andrew J. Freeman Lauren Giuffrida Jack D. Chan Angela Pizzolla Jeffrey Y. W. Mak Timothy R. McCulloch Fernando Souza-Fonseca-Guimaraes Conor J. Kearney Rosemary Millen Robert G. Ramsay Nicholas D. Huntington James McCluskey Jane Oliaro David P. Fairlie Paul J. Neeson Dale I. Godfrey Paul A. Beavis Phillip K. Darcy
author_facet	Emma V. Petley Hui-Fern Koay Melissa A. Henderson Kevin Sek Kirsten L. Todd Simon P. Keam Junyun Lai Imran G. House Jasmine Li Magnus Zethoven Amanda X. Y. Chen Amanda J. Oliver Jessica Michie Andrew J. Freeman Lauren Giuffrida Jack D. Chan Angela Pizzolla Jeffrey Y. W. Mak Timothy R. McCulloch Fernando Souza-Fonseca-Guimaraes Conor J. Kearney Rosemary Millen Robert G. Ramsay Nicholas D. Huntington James McCluskey Jane Oliaro David P. Fairlie Paul J. Neeson Dale I. Godfrey Paul A. Beavis Phillip K. Darcy
author_sort	Emma V. Petley
title	MAIT cells regulate NK cell-mediated tumor immunity
title_short	MAIT cells regulate NK cell-mediated tumor immunity
title_full	MAIT cells regulate NK cell-mediated tumor immunity
title_fullStr	MAIT cells regulate NK cell-mediated tumor immunity
title_full_unstemmed	MAIT cells regulate NK cell-mediated tumor immunity
title_sort	mait cells regulate nk cell-mediated tumor immunity
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/01f893fc7b8b403cadf95ab8ec274a3e
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MAIT cells regulate NK cell-mediated tumor immunity

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