Signaling pathways and intervention therapies in sepsis

Abstract Sepsis is defined as life-threatening organ dysfunction caused by dysregulated host systemic inflammatory and immune response to infection. Over decades, advanced understanding of host–microorganism interaction has gradually unmasked the genuine nature of sepsis, guiding toward new definiti...

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Autores principales:	Yun-yu Zhang, Bo-tao Ning
Formato:	article
Lenguaje:	EN
Publicado:	Nature Publishing Group 2021
Materias:	Medicine R Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/01fb9a9f617b4c75b9be079cf505d432
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spelling	oai:doaj.org-article:01fb9a9f617b4c75b9be079cf505d4322021-11-28T12:08:43ZSignaling pathways and intervention therapies in sepsis10.1038/s41392-021-00816-92059-3635https://doaj.org/article/01fb9a9f617b4c75b9be079cf505d4322021-11-01T00:00:00Zhttps://doi.org/10.1038/s41392-021-00816-9https://doaj.org/toc/2059-3635Abstract Sepsis is defined as life-threatening organ dysfunction caused by dysregulated host systemic inflammatory and immune response to infection. Over decades, advanced understanding of host–microorganism interaction has gradually unmasked the genuine nature of sepsis, guiding toward new definition and novel therapeutic approaches. Diverse clinical manifestations and outcomes among infectious patients have suggested the heterogeneity of immunopathology, while systemic inflammatory responses and deteriorating organ function observed in critically ill patients imply the extensively hyperactivated cascades by the host defense system. From focusing on microorganism pathogenicity, research interests have turned toward the molecular basis of host responses. Though progress has been made regarding recognition and management of clinical sepsis, incidence and mortality rate remain high. Furthermore, clinical trials of therapeutics have failed to obtain promising results. As far as we know, there was no systematic review addressing sepsis-related molecular signaling pathways and intervention therapy in literature. Increasing studies have succeeded to confirm novel functions of involved signaling pathways and comment on efficacy of intervention therapies amid sepsis. However, few of these studies attempt to elucidate the underlining mechanism in progression of sepsis, while other failed to integrate preliminary findings and describe in a broader view. This review focuses on the important signaling pathways, potential molecular mechanism, and pathway-associated therapy in sepsis. Host-derived molecules interacting with activated cells possess pivotal role for sepsis pathogenesis by dynamic regulation of signaling pathways. Cross-talk and functions of these molecules are also discussed in detail. Lastly, potential novel therapeutic strategies precisely targeting on signaling pathways and molecules are mentioned.Yun-yu ZhangBo-tao NingNature Publishing GrouparticleMedicineRBiology (General)QH301-705.5ENSignal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-36 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Biology (General) QH301-705.5
spellingShingle	Medicine R Biology (General) QH301-705.5 Yun-yu Zhang Bo-tao Ning Signaling pathways and intervention therapies in sepsis
description	Abstract Sepsis is defined as life-threatening organ dysfunction caused by dysregulated host systemic inflammatory and immune response to infection. Over decades, advanced understanding of host–microorganism interaction has gradually unmasked the genuine nature of sepsis, guiding toward new definition and novel therapeutic approaches. Diverse clinical manifestations and outcomes among infectious patients have suggested the heterogeneity of immunopathology, while systemic inflammatory responses and deteriorating organ function observed in critically ill patients imply the extensively hyperactivated cascades by the host defense system. From focusing on microorganism pathogenicity, research interests have turned toward the molecular basis of host responses. Though progress has been made regarding recognition and management of clinical sepsis, incidence and mortality rate remain high. Furthermore, clinical trials of therapeutics have failed to obtain promising results. As far as we know, there was no systematic review addressing sepsis-related molecular signaling pathways and intervention therapy in literature. Increasing studies have succeeded to confirm novel functions of involved signaling pathways and comment on efficacy of intervention therapies amid sepsis. However, few of these studies attempt to elucidate the underlining mechanism in progression of sepsis, while other failed to integrate preliminary findings and describe in a broader view. This review focuses on the important signaling pathways, potential molecular mechanism, and pathway-associated therapy in sepsis. Host-derived molecules interacting with activated cells possess pivotal role for sepsis pathogenesis by dynamic regulation of signaling pathways. Cross-talk and functions of these molecules are also discussed in detail. Lastly, potential novel therapeutic strategies precisely targeting on signaling pathways and molecules are mentioned.
format	article
author	Yun-yu Zhang Bo-tao Ning
author_facet	Yun-yu Zhang Bo-tao Ning
author_sort	Yun-yu Zhang
title	Signaling pathways and intervention therapies in sepsis
title_short	Signaling pathways and intervention therapies in sepsis
title_full	Signaling pathways and intervention therapies in sepsis
title_fullStr	Signaling pathways and intervention therapies in sepsis
title_full_unstemmed	Signaling pathways and intervention therapies in sepsis
title_sort	signaling pathways and intervention therapies in sepsis
publisher	Nature Publishing Group
publishDate	2021
url	https://doaj.org/article/01fb9a9f617b4c75b9be079cf505d432
work_keys_str_mv	AT yunyuzhang signalingpathwaysandinterventiontherapiesinsepsis AT botaoning signalingpathwaysandinterventiontherapiesinsepsis
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Signaling pathways and intervention therapies in sepsis

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